DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9426 and KLHL5

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_011512001.1	Gene:	KLHL5 / 51088	HGNCID:	6356	Length:	804	Species:	Homo sapiens

Alignment Length:	627	Identity:	187/627 - (29%)
Similarity:	307/627 - (48%)	Gaps:	75/627 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EYNGNTSPNANANQNANQNPTGGGGDGDFFGQNLGSGATAASHRTNLPSYCNAQYPFKVLSNL-- 73
            |.:..||...|.:.:::...:             .|..|.:|..|..|  |.:...|:.|::.
Human   190 EVDDGTSEEENESDSSSCRTS-------------NSSQTLSSCHTMEP--CTSDEFFQALNHAEQ 239

  Fly    74 ------NQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTID 132
                  |.||.: :.|||.::||...:.|||.|||:.|.||.|||..:  :.|.:|:.:.:..::
Human   240 TFKKMENYLRHK-QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTND--VREARQEEIKMEGVE 301

  Fly   133 GDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAH 197
            .:.|..|:.:.||||.|:.:.|::.||:.|.:|||::||:.||:||.::||.||.|||..||:|.
Human   302 PNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQ 366

  Fly   198 NCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQ 262
            .|..|.|.|.|:...:|..|....||:..|.:.:::||.|:.:.:.:|..:..|.|.|::||:.|
Human   367 GCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQ 431

  Fly   263 RRCYVFDVLSHVRMALVPVKVI-----DKALKDD--CRDM---SVKIALRSICRDIASKRGQLVP 317
            ||..:..:|:::|:.|:..:.:     :...:||  |:.:   ::|..|      :..:|..|..
Human   432 RRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHL------LPERRPMLQS 490

  Fly   318 LRVCPRQLAKKNIYIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSAL 382
            .|..||:.....::.:||.......|         ::.|:|:....||..|.|...|:..||:.|
Human   491 PRTKPRKSTVGTLFAVGGMDSTKGAT---------SIEKYDLRTNMWTPVANMNGRRLQFGVAVL 546

  Fly   383 NGKIYVVGGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGS 447
            :.|:|||||..|.:.|...|.|:|:...|..:.||...|...|:..:.|.::||||..|.....:
Human   547 DDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNT 611

  Fly   448 MECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGG-----CTTTTRHLPDLISFNPVTKEWN 507
            :|.:||:...|..:.:|..||.::||....|.:|.|||     |      |..:..|:|.|.:|.
Human   612 VERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSC------LKSVECFDPHTNKWT 670

  Fly   508 ELARMQTARCQMGVAVLDRYLYVVGG-----SSISQDILSSVERYSFDEDKWTTVCALNVPRAIP 567
            ..|:|...|..:||...:..||.:||     |:::..:...||||....|.||.|.::::.|...
Human   671 LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAV 735

  Fly   568 AVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTW 609
            .|......||..||        |..|..:|.||.|||.::.|
Human   736 GVCLLGDKLYAVGG--------YDGQAYLNTVEAYDPQTNEW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	41/113 (36%)
		PHA03098	78..558	CDD:222983	156/499 (31%)
		BACK	187..289	CDD:285009	31/106 (29%)
		Kelch	330..384	CDD:128874	13/53 (25%)
		KELCH repeat	374..417	CDD:276965	16/42 (38%)
		Kelch	385..431	CDD:128874	16/45 (36%)
		KELCH repeat	421..465	CDD:276965	12/43 (28%)
		Kelch	<447..478	CDD:128874	9/30 (30%)
		Kelch_6	467..516	CDD:290672	17/53 (32%)
		KELCH repeat	468..512	CDD:276965	15/48 (31%)
		Kelch_1	515..557	CDD:279660	15/46 (33%)
		KELCH repeat	516..561	CDD:276965	16/49 (33%)
		KELCH repeat	564..617	CDD:276965	15/46 (33%)
		Kelch	575..627	CDD:128874	13/35 (37%)
KLHL5	XP_011512001.1	BTB	244..347	CDD:279045	40/105 (38%)
		PHA03098	254..775	CDD:222983	172/547 (31%)
		BACK	356..455	CDD:285009	31/98 (32%)
		Kelch	503..548	CDD:128874	13/53 (25%)
		Kelch_1	537..582	CDD:279660	17/44 (39%)
		KELCH repeat	538..581	CDD:276965	16/42 (38%)
		KELCH repeat	585..629	CDD:276965	12/43 (28%)
		Kelch	598..642	CDD:128874	14/43 (33%)
		KELCH repeat	632..675	CDD:276965	15/48 (31%)
		Kelch	643..689	CDD:128874	15/51 (29%)
		Kelch_1	678..729	CDD:279660	16/50 (32%)
		KELCH repeat	679..729	CDD:276965	16/49 (33%)
		Kelch_1	732..772	CDD:279660	15/46 (33%)
		KELCH repeat	732..772	CDD:276965	15/46 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820