DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9426 and Keap1

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001103775.1	Gene:	Keap1 / 50868	MGIID:	1858732	Length:	624	Species:	Mus musculus

Alignment Length:	617	Identity:	190/617 - (30%)
Similarity:	278/617 - (45%)	Gaps:	57/617 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GGGDGDFFGQNLGSGATAASHRTNLP-SYCNAQYPFKVLSNLNQLREQSRFCDV-------EIIA 89
            |.||...:...........|...|.. ||....:..:....:|:||...:.|||       :|.|
Mouse    26 GAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGVMNELRLSQQLCDVTLQVKYEDIPA 90

  Fly    90 GMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQSN 154
              |...||:.||:::|..|:|||..  ||.|...:.|.:..|...::..|::|.||....:.:..
Mouse    91 --AQFMAHKVVLASSSPVFKAMFTN--GLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKC 151

  Fly   155 VQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTL 219
            |..::..|.|.|::.||..|.:||.::|..|||:||..|||...|..|.:.|..:::.:|..|..
Mouse   152 VLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAK 216

  Fly   220 EDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYVFDVLSHVRM-ALVPVKV 283
            ::||.......|:.|::.:.|.|..||:||.|.:.|:|:|..|||.||..:|..||. ||.|..:
Mouse   217 QEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFL 281

  Fly   284 IDKALKDD-------CRDMSVKIALRSICRDIASKRGQLVPLRVCPRQLAKKNIYIIGGSHRDTP 341
            ..:..|.:       |:|..|:|.......    |..|.||.| .|:  ..:.||..||..|.:
Mouse   282 QTQLQKCEILQADARCKDYLVQIFQELTLH----KPTQAVPCR-APK--VGRLIYTAGGYFRQS- 338

  Fly   342 RTWNSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALNGKIYVVGGERGSQILANG----- 401
                     ...:..::.....|...|.::|.|.......:.|.:|.|||...|   .:|
Mouse   339 ---------LSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNS---PDGNTDSS 391

  Fly   402 --EVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSM 464
              :.|:|..:.|.|.|.|.|||...|:..:.|:::||||..|.....|:|.|:||:|.|.|:..|
Mouse   392 ALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPM 456

  Fly   465 PQPRFSMGVVSFEGLIYIVGGCTTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLY 529
            ...|..:||.....|:|.|||...|.| |.....:.|...||..:..|.|.|...||.||...:|
Mouse   457 LTRRIGVGVAVLNRLLYAVGGFDGTNR-LNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIY 520

  Fly   530 VVGGSSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQV 594
            ..||.. .||.|:|||||..:.:.||.|..:...|:...:....|.:||.||        |....
Mouse   521 AAGGYD-GQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGG--------YDGHT 576

  Fly   595 TINAVECYDPLSDTWKNCPDLPVSRSEAGAVV 626
            .:::||||||.||||.....:...||..|..|
Mouse   577 FLDSVECYDPDSDTWSEVTRMTSGRSGVGVAV 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	35/112 (31%)
		PHA03098	78..558	CDD:222983	158/501 (32%)
		BACK	187..289	CDD:285009	36/102 (35%)
		Kelch	330..384	CDD:128874	9/53 (17%)
		KELCH repeat	374..417	CDD:276965	13/49 (27%)
		Kelch	385..431	CDD:128874	16/52 (31%)
		KELCH repeat	421..465	CDD:276965	16/43 (37%)
		Kelch	<447..478	CDD:128874	12/30 (40%)
		Kelch_6	467..516	CDD:290672	16/48 (33%)
		KELCH repeat	468..512	CDD:276965	14/43 (33%)
		Kelch_1	515..557	CDD:279660	18/41 (44%)
		KELCH repeat	516..561	CDD:276965	19/44 (43%)
		KELCH repeat	564..617	CDD:276965	17/52 (33%)
		Kelch	575..627	CDD:128874	19/52 (37%)
Keap1	NP_001103775.1	BTB	67..176	CDD:279045	35/112 (31%)
		PHA03098	95..596	CDD:222983	170/532 (32%)
		BACK	184..286	CDD:285009	36/101 (36%)
		Kelch	327..372	CDD:128874	9/54 (17%)
		Kelch 1	327..372		9/54 (17%)
		KELCH repeat	362..409	CDD:276965	13/49 (27%)
		Kelch	373..423	CDD:128874	16/52 (31%)
		Kelch 2	373..423		16/52 (31%)
		KELCH repeat	413..456	CDD:276965	16/42 (38%)
		Kelch 3	424..470		17/45 (38%)
		Kelch	424..469	CDD:128874	17/44 (39%)
		KELCH repeat	460..503	CDD:276965	14/43 (33%)
		Kelch	471..517	CDD:128874	18/46 (39%)
		Kelch 4	471..517		18/46 (39%)
		KELCH repeat	507..551	CDD:276965	19/44 (43%)
		Kelch	518..564	CDD:128874	15/46 (33%)
		Kelch 5	519..564		15/45 (33%)
		KELCH repeat	554..597	CDD:276965	17/50 (34%)
		Kelch	565..611	CDD:128874	19/52 (37%)
		Kelch 6	565..611		19/52 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820