DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9426 and ivns1abpa

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_954973.2	Gene:	ivns1abpa / 387591	ZFINID:	ZDB-GENE-031222-2	Length:	643	Species:	Danio rerio

Alignment Length:	609	Identity:	154/609 - (25%)
Similarity:	281/609 - (46%)	Gaps:	74/609 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPEL---GLNEVKQKSVVLHTI 131
            ::.:|.||:..:||||.:......|.||||||:..|.|...:|..:|   |::.||     ...:
Zfish    19 VAKMNALRKNGQFCDVRLQVCGHELMAHRAVLACCSPYLFEIFNSDLEPHGISHVK-----FEDL 78

  Fly   132 DGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEA 196
            |.:.:.|||::.||.:.:..:..|:|:.:||..|:::.|...|.::|..::.:.:|:....||..
Zfish    79 DPEAVEILLNYAYTAQLKADKELVKEVYSAAKRLKMDRVKQICGDYLLSKMDSQSAISYRNFASC 143

  Fly   197 HNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVT 261
            .....|.....:::..:...|:.:::||:.|:..|..:|... |.:.|..:::...:.|::..:.
Zfish   144 MGDGRLLGKIDSYIQEHLLEVSEQEDFLKLPRLKLEVMLEDN-LTLPSNGKLYSKVIGWVQRSLW 207

  Fly   262 QRRCYVFDVLSHVRMALVPV--KVIDKAL-----------KDDCRDMSVKIALRSICRDIA-SKR 312
            :....:..::..|:......  |::|.:|           .|..:.:..|....::.|.:: |..
Zfish   208 ENGEPLERLMEEVQTLYYSADHKLLDGSLLDGQAEVFGTEDDHIQFVQKKPPRENVHRQLSTSSS 272

  Fly   313 GQLVP---LRVCPRQ----------------LAKKN-----IYIIGGSHRDTPRTWNSA-DCIFE 352
            |.|.|   ...|.::                ||..|     |::.|   |.:|:...|| .|:.:
Zfish   273 GSLSPGSTKHPCKQEWKYIASEKTTNNTYLCLAVLNGMLCVIFLHG---RSSPQASPSATPCLTK 334

  Fly   353 TVAKFDIFRREWTE------TAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQNDVW 411
            :::    |..:..|      .:||...|...|:::||.::...||....:.|...|.|:.:.:.|
Zfish   335 SLS----FEGQPLEEEPDKLLSPMHYARSGLGIASLNDQLIAAGGYNREECLRTVECYNIKTNSW 395

  Fly   412 QPIAPMIVPRCEFGLCTMGGNLFAVGGWIG--DDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVV 474
            ..||||..||..|.:..:.|.|:.:||..|  |::... |.|:|..|.|..:..:...|.:.||.
Zfish   396 TFIAPMRTPRARFQMAVLMGQLYVMGGSNGHSDELSCG-ETYNPNADEWTQVPELRTNRCNAGVC 459

  Fly   475 SFEGLIYIVGGCTTT-TRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSSISQ 538
            |....:|:|||.... .:.|.:...|:|::|.|...|.:...|.|..|..||.::||:||:. |.
Zfish   460 SLNNKLYVVGGSDPCGQKGLKNCDVFDPISKAWTNCAPLNIRRHQAAVCELDGFMYVIGGAE-SW 523

  Fly   539 DILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYD 603
            :.|:|||||:.:.:.||.:.::|:.|....|...:|.|:|.||        :.....:..||.||
Zfish   524 NCLNSVERYNPENNTWTLIASMNIARRGAGVAVYEGKLFVVGG--------FDGSHALRCVEMYD 580

  Fly   604 PLSDTWKNCPDLPVSRSEAGAVVV 627
            |:.:.|:....:...||.|||.|:
Zfish   581 PVRNEWRMLGSMNSPRSNAGAAVL 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	34/108 (31%)
		PHA03098	78..558	CDD:222983	131/530 (25%)
		BACK	187..289	CDD:285009	17/114 (15%)
		Kelch	330..384	CDD:128874	14/60 (23%)
		KELCH repeat	374..417	CDD:276965	12/42 (29%)
		Kelch	385..431	CDD:128874	13/45 (29%)
		KELCH repeat	421..465	CDD:276965	13/45 (29%)
		Kelch	<447..478	CDD:128874	9/30 (30%)
		Kelch_6	467..516	CDD:290672	14/49 (29%)
		KELCH repeat	468..512	CDD:276965	14/44 (32%)
		Kelch_1	515..557	CDD:279660	18/41 (44%)
		KELCH repeat	516..561	CDD:276965	18/44 (41%)
		KELCH repeat	564..617	CDD:276965	13/52 (25%)
		Kelch	575..627	CDD:128874	15/51 (29%)
ivns1abpa	NP_954973.2	BTB	23..634	CDD:333434	154/605 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..282		6/24 (25%)
		KELCH repeat	358..401	CDD:276965	12/42 (29%)
		Kelch 1	369..415		13/45 (29%)
		KELCH repeat	405..450	CDD:276965	13/45 (29%)
		Kelch 2	416..463		14/47 (30%)
		KELCH repeat	453..498	CDD:276965	14/44 (32%)
		Kelch 3	465..512		14/46 (30%)
		KELCH repeat	502..545	CDD:276965	18/43 (42%)
		Kelch 4	513..559		16/46 (35%)
		KELCH repeat	549..593	CDD:276965	13/51 (25%)
		Kelch 5	560..606		16/53 (30%)
		KELCH repeat	596..638	CDD:276965	6/9 (67%)
		Kelch 6	608..643
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910