DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9426 and CG15097

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster

Alignment Length:	649	Identity:	202/649 - (31%)
Similarity:	315/649 - (48%)	Gaps:	74/649 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PLKTYQIHEYNGNTSPNANANQNANQNPTGGGGDGDFFGQNLGSGATAASHRTNLPSYCNAQYPF 67
            |:|:....|.:||.......:.|:.|.|:      |.............:|..| |.:|.|.:
  Fly     4 PVKSNHSGEASGNNEDVTTTSNNSTQTPS------DLSPPGPNEEVLPQAHHQN-PGHCIASF-- 59

  Fly    68 KVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTID 132
               :.:||:|..::.|||.:..|..|::|||.||::.|.||.|||..:  :.|..|..|.||.:|
  Fly    60 ---AAINQMRNNAQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDD--MLERTQGLVRLHDVD 119

  Fly   133 GDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAH 197
            ...|..|:|:.|||...||:.|||.||.|:.:||::.|.|.||:||.|:||.||.|||..||:||
  Fly   120 SSALRQLIDYTYTGEITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAH 184

  Fly   198 NCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQ 262
            :|:.|...:..:...||..|...:|||..|...:.:|:::..|.:.||.:||.|.:.|:|||:..
  Fly   185 SCKELHTRSHKYALQNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPT 249

  Fly   263 RRCYVFDVLSHVRMALVPVKVI------DKALKDD--CRDM---SVKIAL----RSICRDIASKR 312
            ||.::.:::|:||:.||....:      :..::||  |:::   ::|..|    |||   :.|:|
  Fly   250 RRLHIAELMSNVRLPLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSI---MGSQR 311

  Fly   313 GQLVPLRVCPRQLAKKNIYIIGGS-----HRD----TPRTWNSADCIFETVAKFDIFRREWTETA 368
            .|    ...|..: |..::.:||.     |.:    .||: ||                 |:..|
  Fly   312 TQ----ERRPEGM-KPYVFAVGGGSLFAIHNECEVYNPRS-NS-----------------WSPVA 353

  Fly   369 PMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNL 433
            ||...|...||::|:.::|||||..|...||..|.|:|..:.|..|.||...|...|:|:....:
  Fly   354 PMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLTNKWSNITPMGTKRSCLGICSYDALI 418

  Fly   434 FAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGGCTTTTRHLPDLIS 498
            :..||:.|.....|||.|||...:|....:|...|....:...|..||.:|| ..:|.:...:..
  Fly   419 YVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRLAVLENCIYSLGG-FDSTNYQSSVER 482

  Fly   499 FNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDEDKWTTVCALNVP 563
            |:|....|..:..|...|...|||..|.:||.:||:..:. .:||.||:|...:.|..:.|::..
  Fly   483 FDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDGTM-CMSSGERFSLRRNSWEPIAAMHSR 546

  Fly   564 RAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEAGAVVV 627
            |:...||..:|.|:..||:.        ...::|:||.||...:.|.....:...||..||.|:
  Fly   547 RSTHEVVEVEGALFALGGND--------GSSSLNSVERYDTRLNKWSVVNAMVARRSSVGAAVL 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	46/105 (44%)
		PHA03098	78..558	CDD:222983	166/503 (33%)
		BACK	187..289	CDD:285009	34/107 (32%)
		Kelch	330..384	CDD:128874	15/62 (24%)
		KELCH repeat	374..417	CDD:276965	17/42 (40%)
		Kelch	385..431	CDD:128874	18/45 (40%)
		KELCH repeat	421..465	CDD:276965	13/43 (30%)
		Kelch	<447..478	CDD:128874	9/30 (30%)
		Kelch_6	467..516	CDD:290672	11/48 (23%)
		KELCH repeat	468..512	CDD:276965	10/43 (23%)
		Kelch_1	515..557	CDD:279660	15/41 (37%)
		KELCH repeat	516..561	CDD:276965	16/44 (36%)
		KELCH repeat	564..617	CDD:276965	13/52 (25%)
		Kelch	575..627	CDD:128874	13/51 (25%)
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	46/104 (44%)
		PHA03098	65..539	CDD:222983	167/503 (33%)
		BACK	174..276	CDD:285009	34/101 (34%)
		Kelch	324..369	CDD:128874	15/62 (24%)
		KELCH repeat	359..402	CDD:276965	17/42 (40%)
		Kelch	370..415	CDD:128874	18/44 (41%)
		KELCH repeat	406..450	CDD:276965	13/43 (30%)
		Kelch	417..463	CDD:128874	12/45 (27%)
		KELCH repeat	453..496	CDD:276965	10/43 (23%)
		Kelch	464..510	CDD:128874	13/46 (28%)
		Kelch_1	499..543	CDD:279660	15/44 (34%)
		KELCH repeat	500..545	CDD:276965	16/45 (36%)
		KELCH repeat	547..590	CDD:276965	13/50 (26%)
		Kelch	559..603	CDD:128874	14/52 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464352
Domainoid	1	1.000	52	1.000	Domainoid score	I4252
eggNOG	1	0.900	-	-		E1_KOG4441
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		otm2846
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900