DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9426 and keap1a

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_878284.2	Gene:	keap1a / 321837	ZFINID:	ZDB-GENE-030131-556	Length:	601	Species:	Danio rerio

Alignment Length:	595	Identity:	174/595 - (29%)
Similarity:	274/595 - (46%)	Gaps:	72/595 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 YCNAQYPFKVLSNLNQLREQSRFCDVEIIA----GMATLSAHRAVLSAASAYFEAMFRPELGLNE 120
            |....:|.|.|.|:::||.....||:.:..    .:.....|:.||:|:|.||:|||..  ...|
Zfish    31 YTVESHPSKALQNMDELRHHEMLCDLVLHVTYKDKIVDFKVHKLVLAASSPYFKAMFTS--NFKE 93

  Fly   121 VKQKSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHAS 185
            .....|.|..:...::..|:||.||.|..:.::.|..:|..|...|:.||...||:||.:.|..|
Zfish    94 CHASEVTLRDVCPQVISRLIDFAYTSRITVGETCVLHVLLTAMRYQMEEVAKACCDFLMKNLEPS 158

  Fly   186 NALGILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQ 250
            |.:||.||||...|..|......:::.:|..||.|:||.......|.:|::.:.|:|..||:|::
Zfish   159 NVIGISRFAEEIGCTDLHLRTREYINTHFNEVTKEEEFFSLSHCQLLELISQDSLKVLCESEVYK 223

  Fly   251 AALRWIKHDVTQRRCYVFDVLSHVRMALVPVKVIDKALK--------DDCRDMSVKIALRSICRD 307
            |.:.|::.|...|..|...:|:.|.:..:|...:.:.|:        :.|:|.     |..|..:
Zfish   224 ACIDWVRWDAESRAQYFHALLNAVHIYALPPTFLKRQLQSCPILSKANSCKDF-----LSKIFHE 283

  Fly   308 IASKRGQLVPLRVCPRQLAKKNIYIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWTETAPMEV 372
            :|.::    ||...|.: ..:.|||.||..:.:          .:|:..||..:..|     :::
Zfish   284 MALRK----PLPPTPHR-GTQLIYIAGGYKQHS----------LDTLEAFDPHKNVW-----LKL 328

  Fly   373 GRILP-----GVSALNGKIYVVGGERGSQILANGE-----VYDPQNDVWQPIAPMIVPRCEFGLC 427
            |.::.     |...|.|.:|.||| |...:..|.|     .|:|..:.|..:||:..||...|:.
Zfish   329 GSMMSPCSGLGACVLFGLLYTVGG-RNLSLQNNTESGSLSCYNPMTNQWTQLAPLNTPRNRVGVG 392

  Fly   428 TMGGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGG------C 486
            .:.|:::||||........|:|.||||.:.|..:..|...|...||.:..|.:|:|||      .
Zfish   393 VIDGSIYAVGGSHASTHHNSVERYDPETNRWTFVAPMSVARLGAGVAACGGCLYVVGGFDGDNRW 457

  Fly   487 TTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDE 551
            .|..|:.||       |..|..:|.|.|.|..:||..:|.|||.|||.. .|..|.::|||:...
Zfish   458 NTVERYQPD-------TNTWQHVAPMNTVRSGLGVVCMDNYLYAVGGYD-GQTQLKTMERYNITR 514

  Fly   552 DKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLP 616
            |.|..:.::|..|:...|......::|.||        :.....:::||||.|.|:.|....|:|
Zfish   515 DVWEPMASMNHCRSAHGVSVYQCKIFVLGG--------FNQGGFLSSVECYCPASNVWTLVTDMP 571

  Fly   617 VSRSEAGAVV 626
            |.||..|..|
Zfish   572 VGRSGMGVAV 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	32/109 (29%)
		PHA03098	78..558	CDD:222983	147/507 (29%)
		BACK	187..289	CDD:285009	29/101 (29%)
		Kelch	330..384	CDD:128874	12/58 (21%)
		KELCH repeat	374..417	CDD:276965	14/52 (27%)
		Kelch	385..431	CDD:128874	15/50 (30%)
		KELCH repeat	421..465	CDD:276965	14/43 (33%)
		Kelch	<447..478	CDD:128874	11/30 (37%)
		Kelch_6	467..516	CDD:290672	17/54 (31%)
		KELCH repeat	468..512	CDD:276965	15/49 (31%)
		Kelch_1	515..557	CDD:279660	17/41 (41%)
		KELCH repeat	516..561	CDD:276965	17/44 (39%)
		KELCH repeat	564..617	CDD:276965	13/52 (25%)
		Kelch	575..627	CDD:128874	17/52 (33%)
keap1a	NP_878284.2	BTB_POZ_KLHL19_KEAP1	33..156	CDD:349557	37/124 (30%)
		PHA03098	54..571	CDD:222983	161/560 (29%)
		Kelch 1. /evidence=ECO:0000255	292..337		11/60 (18%)
		KELCH repeat	336..382	CDD:276965	14/46 (30%)
		Kelch 2. /evidence=ECO:0000255	338..388		17/50 (34%)
		KELCH repeat	386..429	CDD:276965	14/42 (33%)
		Kelch 3. /evidence=ECO:0000255	389..435		15/45 (33%)
		KELCH repeat	433..477	CDD:276965	15/50 (30%)
		Kelch 4. /evidence=ECO:0000255	436..482		17/52 (33%)
		KELCH repeat	480..525	CDD:276965	17/45 (38%)
		Kelch 5. /evidence=ECO:0000255	484..529		18/45 (40%)
		KELCH repeat	527..572	CDD:276965	13/52 (25%)
		Kelch 6. /evidence=ECO:0000255	530..576		15/53 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820