DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9426 and Klhl5

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001040558.1	Gene:	Klhl5 / 305351	RGDID:	1309661	Length:	708	Species:	Rattus norvegicus

Alignment Length:	638	Identity:	195/638 - (30%)
Similarity:	316/638 - (49%)	Gaps:	72/638 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HEYNGNTSPNANANQNANQNPTGGGGDGDFFGQNLGSGATAASHRTNLPSYCNAQYPFKVLSNLN 74
            :|.:.::|..:|::|..:...|......|.|.|.|.                :|:..||.:.  |
  Rat   119 NESDSSSSRTSNSSQTLSSCQTMEPCSSDEFFQALN----------------HAEQTFKKME--N 165

  Fly    75 QLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHIL 139
            .||.: :.|||.::||...:.|||.|||:.|.||.|||..:  :.|.:|:.:.:..::.:.|..|
  Rat   166 YLRHK-QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTND--VREARQEEIKMEGVEPNSLWSL 227

  Fly   140 LDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAK 204
            :.:.||||.|:.:.|::.||:.|.:|||::||:.||:||.::||.||.|||..||:|..|..|.|
  Rat   228 IQYAYTGRLELKEENIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHK 292

  Fly   205 SALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYVFD 269
            .|.|:...:|..|....||:..|...:::||.|:.:.:.:|..:..|.|.|::||:.||:..:..
  Rat   293 VAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRQKDLSK 357

  Fly   270 VLSHVRMALVPVKVI----DKAL-KDD--CRDM---SVKIALRSICRDIASKRGQLVPLRVCPRQ 324
            :|:::|:.|:..:.:    :.|| :||  |:.:   ::|..|      :..:|..|...|..||:
  Rat   358 LLAYIRLPLLAPQFLADMENNALFRDDIECQKLIMEAMKYHL------LPERRPMLQSPRTKPRK 416

  Fly   325 LAKKNIYIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALNGKIYVV 389
            .....::.:||.......|         ::.|:|:....||..|.|...|:..||:.|:.|:|||
  Rat   417 STVGTLFAVGGMDSTKGAT---------SIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVV 472

  Fly   390 GGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYDPE 454
            ||..|.:.|...|.|:|:...|..:.||...|...|:..:.|.::||||..|.....::|.:||:
  Rat   473 GGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQ 537

  Fly   455 QDLWKLMGSMPQPRFSMGVVSFEGLIYIVGG-----CTTTTRHLPDLISFNPVTKEWNELARMQT 514
            ...|..:.:|..||.::||....|.:|.|||     |      |..:..|:|.|.:|...|:|..
  Rat   538 ARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSC------LKSVECFDPHTNKWTLCAQMSK 596

  Fly   515 ARCQMGVAVLDRYLYVVGG-----SSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADG 574
            .|..:||...:..||.:||     |:::..:...||||....|.||.|.::::.|....|.....
  Rat   597 RRGGVGVTTWNGLLYAIGGHDAPTSNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 661

  Fly   575 LLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEAGAVVV 627
            .||..||        |..|..:|.||.|||.::.|.....|.:.|  |||.||
  Rat   662 KLYAVGG--------YDGQTYLNIVEAYDPQTNEWTQVAPLCLGR--AGACVV 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	41/105 (39%)
		PHA03098	78..558	CDD:222983	157/499 (31%)
		BACK	187..289	CDD:285009	32/106 (30%)
		Kelch	330..384	CDD:128874	13/53 (25%)
		KELCH repeat	374..417	CDD:276965	16/42 (38%)
		Kelch	385..431	CDD:128874	16/45 (36%)
		KELCH repeat	421..465	CDD:276965	12/43 (28%)
		Kelch	<447..478	CDD:128874	9/30 (30%)
		Kelch_6	467..516	CDD:290672	17/53 (32%)
		KELCH repeat	468..512	CDD:276965	15/48 (31%)
		Kelch_1	515..557	CDD:279660	15/46 (33%)
		KELCH repeat	516..561	CDD:276965	16/49 (33%)
		KELCH repeat	564..617	CDD:276965	16/52 (31%)
		Kelch	575..627	CDD:128874	18/51 (35%)
Klhl5	NP_001040558.1	BTB	163..266	CDD:279045	40/107 (37%)
		PHA03098	173..695	CDD:222983	173/552 (31%)
		BACK	275..374	CDD:285009	30/98 (31%)
		Kelch	422..467	CDD:128874	13/53 (25%)
		Kelch_1	456..501	CDD:279660	17/44 (39%)
		KELCH repeat	457..500	CDD:276965	16/42 (38%)
		KELCH repeat	504..548	CDD:276965	12/43 (28%)
		Kelch	517..561	CDD:128874	14/43 (33%)
		KELCH repeat	551..594	CDD:276965	15/48 (31%)
		Kelch	562..608	CDD:128874	15/51 (29%)
		Kelch_1	597..648	CDD:279660	16/50 (32%)
		KELCH repeat	598..648	CDD:276965	16/49 (33%)
		Kelch_1	651..694	CDD:279660	15/50 (30%)
		KELCH repeat	651..694	CDD:276965	15/50 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820