DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9426 and Klhl8

DIOPT Version :10

Sequence 1:NP_609616.1 Gene:CG9426 / 34719 FlyBaseID:FBgn0032485 Length:627 Species:Drosophila melanogaster
Sequence 2:NP_001099465.1 Gene:Klhl8 / 289457 RGDID:1304685 Length:621 Species:Rattus norvegicus


Alignment Length:564 Identity:176/564 - (31%)
Similarity:267/564 - (47%) Gaps:44/564 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 EQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHILLDF 142
            |....|||.:..|...:|.|:..|:....||.|||..|  ::|.||..:.:...|||.:..|:.|
  Rat    63 ENGELCDVTLKVGSKLISCHKLALACVIPYFRAMFLSE--MSEAKQALIEIRDFDGDAVEDLVKF 125

  Fly   143 IYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSAL 207
            :|:.|..:|..|||.||.||.:||:..|...|||::....|.||.|.:..|||:||...|...|.
  Rat   126 VYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRTDLMDMAD 190

  Fly   208 NFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYVFDVLS 272
            .:...:|..|...::|:......|.:||:|..|.:|||.||:.||::|:..:......::.:.|:
  Rat   191 QYACEHFTEVVECEDFVSVSPQHLHKLLSSSDLNIDSEKQVYSAAIKWLLANPQHHPKWLDETLA 255

  Fly   273 HVRMALVPV----------KVIDKALKDDCRDMSVKIALRSICRDIASKRGQLVP-----LRVCP 322
            .||:.|:||          :::.:.||  |||:..:  .|:....::||.   ||     :|..|
  Rat   256 QVRLPLLPVDFLMGVVAKEQIVKQNLK--CRDLLDE--ARNYHLHLSSKP---VPDFEYSVRTTP 313

  Fly   323 RQLAKKNIYIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALNGKIY 387
            |:.....::.:||       ...|.| .|.::..:.|....|.....|...|...||.::.||:|
  Rat   314 RKHTAGVLFCVGG-------RGGSGD-PFRSIECYSINTNSWFFGPEMNSRRRHVGVISVEGKVY 370

  Fly   388 VVGGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYD 452
            .|||..|::.|.:.|::||..:.|...|.|...|....|.::||.::|:||...:.....:|.||
  Rat   371 AVGGHDGNEHLGSMEMFDPLTNKWMVKASMNTKRRGIALASLGGPIYAIGGLDDNTCFSDVERYD 435

  Fly   453 PEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGGCTTTTRHLPDLISFNPVTKEWNELARMQTARC 517
            .|.|.|..:..|..||..:|.|:....:|.||| ......|..:..::|...:|.|:..|...|.
  Rat   436 IESDQWSTVAPMNTPRGGVGSVALINHVYAVGG-NDGVASLSSVERYHPHLDKWVEVKEMGQRRA 499

  Fly   518 QMGVAVLDRYLYVVGGSSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGD 582
            ..||:.|...||||||.. ....|||||||....:||..|.||..||....:....|.::..|| 
  Rat   500 GNGVSELHGCLYVVGGFD-DNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGG- 562

  Fly   583 QPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEAGAVV 626
                   :.....:|.||.:||:.:.|:...  |||...|||.|
  Rat   563 -------HNGNAYLNTVEAFDPVLNKWELVG--PVSHCRAGAGV 597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9426NP_609616.1 BTB_POZ_KLHL27_IPP 63..189 CDD:349565 41/110 (37%)
PHA03098 78..558 CDD:222983 155/494 (31%)
KELCH repeat 374..417 CDD:276965 16/42 (38%)
KELCH repeat 421..465 CDD:276965 13/43 (30%)
KELCH repeat 468..512 CDD:276965 11/43 (26%)
KELCH repeat 516..561 CDD:276965 21/44 (48%)
KELCH repeat 564..617 CDD:276965 10/52 (19%)
Kelch 575..627 CDD:128874 15/52 (29%)
Klhl8NP_001099465.1 BTB_POZ_KLHL8 53..172 CDD:349547 41/110 (37%)
PHA03098 61..536 CDD:222983 154/491 (31%)
KELCH repeat 357..400 CDD:276965 16/42 (38%)
KELCH repeat 404..448 CDD:276965 13/43 (30%)
KELCH repeat 451..496 CDD:276965 12/45 (27%)
KELCH repeat 498..543 CDD:276965 22/45 (49%)
KELCH repeat 545..587 CDD:276965 10/51 (20%)
Kelch 556..601 CDD:128874 15/52 (29%)

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