DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9426 and KLHL20

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_016856541.1	Gene:	KLHL20 / 27252	HGNCID:	25056	Length:	684	Species:	Homo sapiens

Alignment Length:	588	Identity:	198/588 - (33%)
Similarity:	291/588 - (49%)	Gaps:	53/588 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 YCNAQYPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQK 124
            |.:.::|.:.|..:|.||:....|||.::.|...:.|||.:|||.|.||.|||..||.  |.:|.
Human   120 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELA--ESRQT 182

  Fly   125 SVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALG 189
            .||:..||...:.:|:||.||.:..:.:.|||.||.||.:|||.|:.:.|||||.|:|..||.||
Human   183 EVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLG 247

  Fly   190 ILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALR 254
            |..||:.|:|..|.:.|..|...||..|...:||:..|...|..:::|:.|.|.||.|||.|.:.
Human   248 IRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMA 312

  Fly   255 WIKHDVTQRRCYVFDVLSHVRMALVPVKVI------DKALKDD--CRDMSVKIALRSICRDIASK 311
            |:|:.:.:||..:..||.|||:.|:..|.:      |..:|.|  |||:            :...
Human   313 WVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDL------------VDEA 365

  Fly   312 RGQLV-----PLRVCPRQLAKKNI------YIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWT 365
            :..|:     ||...||...:|.|      :.:||        |.|.|.| .:|.::|....||.
Human   366 KNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGG--------WCSGDAI-SSVERYDPQTNEWR 421

  Fly   366 ETAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQNDVW-QPIAPMIVPRCEFGLCTM 429
            ..|.|...|...|||.|:..:|.|||..||..|.:.|.|||:.:.| ..:||....|...|:..:
Human   422 MVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVL 486

  Fly   430 GGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGGCTTTTRHLP 494
            ||.|:||||..|......:|.|||:::.|..:.||...|..:.|....|.:|.||| :..|..|.
Human   487 GGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGG-SDGTSPLN 550

  Fly   495 DLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDEDKWTTVCA 559
            .:..:||....|:.:|.|.|.|..:|.||....:|.|||...:.: |||.|||:...::|:.|.|
Human   551 TVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTE-LSSAERYNPRTNQWSPVVA 614

  Fly   560 LNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEAGA 624
            :...|:...:...:|.|...||        :.....:..:|.:||.::||:....:...|...|.
Human   615 MTSRRSGVGLAVVNGQLMAVGG--------FDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGV 671

  Fly   625 VVV 627
            .|:
Human   672 GVI 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	47/105 (45%)
		PHA03098	78..558	CDD:222983	177/499 (35%)
		BACK	187..289	CDD:285009	38/107 (36%)
		Kelch	330..384	CDD:128874	18/59 (31%)
		KELCH repeat	374..417	CDD:276965	18/43 (42%)
		Kelch	385..431	CDD:128874	16/46 (35%)
		KELCH repeat	421..465	CDD:276965	16/43 (37%)
		Kelch	<447..478	CDD:128874	9/30 (30%)
		Kelch_6	467..516	CDD:290672	15/48 (31%)
		KELCH repeat	468..512	CDD:276965	13/43 (30%)
		Kelch_1	515..557	CDD:279660	15/41 (37%)
		KELCH repeat	516..561	CDD:276965	17/44 (39%)
		KELCH repeat	564..617	CDD:276965	10/52 (19%)
		Kelch	575..627	CDD:128874	10/51 (20%)
KLHL20	XP_016856541.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820