Protein Alignment CG9426 and Klhl18

DIOPT Version :10

• Sequence 1: NP_609616.1
• Gene: CG9426 / 34719
• FlyBaseID: FBgn0032485
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_001347235.1
• Gene: Klhl18 / 270201
• MGIID: 2143315
• Length: 579
• Species: Mus musculus
• Alignment Length: 595
• Identity: 194/595 - (32%)
• Similarity: 290/595 - (48%)
• Gaps: 48/595 - (8%)

  Fly    51 ASHRTNLPSYCNAQYPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPE 115
            |....:|..:..::.|.:....:.::|.|.:.|||.:..|....||||.||:|:..||.|||..:
Mouse     6 AEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTND 70

  Fly   116 LGLNEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCR 180
              :.|.||..:|:..:|...|..|::|.|.|...|.|.|||.||..|..|||..:.|.||.||..
Mouse    71 --MMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRE 133

  Fly   181 ELHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSE 245
            .||..|.||:.:|||...|..|..:|.:|:|.:|..|:|.:|||..|...:.:|::.:.|.|.||
Mouse   134 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSLSEEFLALPLEDVLELVSRDELNVKSE 198

  Fly   246 SQVFQAALRWIKHDVTQRRCYVFDVLSHVRMALV-PVKVIDKALKDD-------CRDMSVKIALR 302
            .|||:|||.|:::|..||...:.::||::|:.|. |..:.|:..:||       |||      |.
Mouse   199 EQVFEAALAWVRYDREQRGPCLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRD------LV 257

  Fly   303 SICRD---IASKRGQLVPLRVCPR---QLAKKNIYIIGGSHRDTPRTWNSADCIFETVAKFDIFR 361
            ...:|   :..:|..|...|..||   .:|.. ||.:||  .::...:.:.|.: ..|..||...
Mouse   258 DEAKDYHLMPERRPHLPAFRTRPRCCTSIAGL-IYAVGG--LNSAANFYAGDSL-NVVEVFDPIA 318

  Fly   362 REWTETAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGL 426
            ..|.:..||...|...||:.:||.:|.:||..|...|:..|.|:|:.|.|..:..|...|...|.
Mouse   319 NRWEKCHPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGT 383

  Fly   427 CTMGGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGG-----C 486
            ..:.|.::..||:.|:....|:|.|.||.|.|.::..|...|.:.||..|||.||:.||     .
Mouse   384 VVLDGQIYVCGGYDGNSSLNSVETYSPETDKWTVVTPMSSNRSAAGVTVFEGRIYVSGGHDGLQI 448

  Fly   487 TTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDE 551
            .::..|      :|..|..|:..|.|...||:.|.|.|...::|.||.. ....||..|.||...
Mouse   449 FSSVEH------YNHHTATWHPAASMLNKRCRHGAASLGSKMFVCGGYD-GSGFLSIAEMYSSVA 506

  Fly   552 DKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLP 616
            |:|..:..::..|:..::||:.|.||..||        |..|..:::||.|||.:|.|...  .|
Mouse   507 DQWCLIVPMHTRRSRVSLVASCGRLYAVGG--------YDGQSNLSSVEMYDPETDRWTFM--AP 561

  Fly   617 VSRSEAGAVV 626
            ::..|.|..|
Mouse   562 MACHEGGVGV 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB_POZ_KLHL27_IPP	63..189	CDD:349565	48/125 (38%)
		PHA03098	78..558	CDD:222983	169/498 (34%)
		KELCH repeat	374..417	CDD:276965	15/42 (36%)
		KELCH repeat	421..465	CDD:276965	13/43 (30%)
		KELCH repeat	468..512	CDD:276965	15/48 (31%)
		KELCH repeat	516..561	CDD:276965	15/44 (34%)
		KELCH repeat	564..617	CDD:276965	17/52 (33%)
		Kelch	575..627	CDD:128874	17/52 (33%)
Klhl18	NP_001347235.1	BTB_POZ_KLHL18	19..134	CDD:349556	45/116 (39%)
		PHA03098	34..557	CDD:222983	185/549 (34%)
		BACK_KLHL18	135..241	CDD:350532	41/105 (39%)
		KELCH repeat	282..327	CDD:276965	10/48 (21%)
		KELCH repeat	331..374	CDD:276965	15/42 (36%)
		Kelch 2. /evidence=ECO:0000255	342..388		13/45 (29%)
		KELCH repeat	378..422	CDD:276965	13/43 (30%)
		Kelch 3. /evidence=ECO:0000255	389..435		15/45 (33%)
		KELCH repeat	425..469	CDD:276965	15/49 (31%)
		Kelch 4. /evidence=ECO:0000255	437..482		15/50 (30%)
		KELCH repeat	472..516	CDD:276965	15/44 (34%)
		Kelch 5. /evidence=ECO:0000255	484..529		13/45 (29%)
		KELCH repeat	519..562	CDD:276965	17/52 (33%)
		Kelch 6. /evidence=ECO:0000255	530..576		17/52 (33%)