DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9426 and Klhl17

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_006239583.1	Gene:	Klhl17 / 246757	RGDID:	708444	Length:	650	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	188/575 - (32%)
Similarity:	286/575 - (49%)	Gaps:	44/575 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILH 137
            ::::|::...||:.:......:.||:.||::.|.||.|||..|  ::|.:|..|.||.||...|.
  Rat    80 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNE--MSESRQTHVTLHDIDPQALD 142

  Fly   138 ILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESL 202
            .|:.|.||....:.:.|||.||.||.:||||.|.|.||:||..:|..||.|||..||:.|:|..|
  Rat   143 QLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDL 207

  Fly   203 AKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYV 267
            .|:|..:|..:|..|...:||:..|...:.:|::|:.|.|.||..|::|.|.|:||||..||.:|
  Rat   208 LKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEDVYRAVLSWVKHDVDTRRQHV 272

  Fly   268 FDVLSHVRMALVPVKVI------DKALK--DDCRDMSVKIALRSICRDIASKRGQLVPLRVCPRQ 324
            ..::..||:.|:....:      :..::  .||:|:.:: ||:  ...:..:||.|...|..||:
  Rat   273 PRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE-ALK--FHLLPEQRGVLGTSRTRPRR 334

  Fly   325 L--AKKNIYIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALNGKIY 387
            .  |...::.:||         .|...|......:|.....|...|.|...|...||:|:..::|
  Rat   335 CEGAGPVLFAVGG---------GSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLY 390

  Fly   388 VVGGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYD 452
            .|||..|:..||..|.|||..:.|||...|...|...|:..:.|.|:|.||:.|.....|.|.||
  Rat   391 AVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYAAGGYDGASCLNSAERYD 455

  Fly   453 PEQDLWKLMGSMPQPRFSMGVVSF----------EGLIYIVGGCTTTTRHLPDLISFNPVTKEWN 507
            |....|..:.:|...|..:.|.:.          :|.:|.|||..::: ||..:..:.|....|.
  Rat   456 PLTGTWTSIAAMSTRRRYVRVATLGASWVYCLPTDGNLYAVGGYDSSS-HLATVEKYEPQVNSWT 519

  Fly   508 ELARMQTARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAA 572
            .:|.|.:.|...|||||:..|||.||:. ....|:||||||.....|.:|..:|:.|:...:||.
  Rat   520 PVASMLSRRSSAGVAVLEGALYVAGGND-GTSCLNSVERYSTKAGAWESVAPMNIRRSTHDLVAM 583

  Fly   573 DGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEAGAVVV 627
            ||.||..||:.        ...::|::|.|:|.::.|.....:...||..|..|:
  Rat   584 DGWLYAVGGND--------GSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVL 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	42/105 (40%)
		PHA03098	78..558	CDD:222983	167/499 (33%)
		BACK	187..289	CDD:285009	36/107 (34%)
		Kelch	330..384	CDD:128874	12/53 (23%)
		KELCH repeat	374..417	CDD:276965	18/42 (43%)
		Kelch	385..431	CDD:128874	17/45 (38%)
		KELCH repeat	421..465	CDD:276965	14/43 (33%)
		Kelch	<447..478	CDD:128874	9/40 (23%)
		Kelch_6	467..516	CDD:290672	13/58 (22%)
		KELCH repeat	468..512	CDD:276965	12/53 (23%)
		Kelch_1	515..557	CDD:279660	19/41 (46%)
		KELCH repeat	516..561	CDD:276965	20/44 (45%)
		KELCH repeat	564..617	CDD:276965	14/52 (27%)
		Kelch	575..627	CDD:128874	12/51 (24%)
Klhl17	XP_006239583.1	BTB_POZ_KLHL17_actinfilin	51..189	CDD:349555	44/110 (40%)
		PHA03098	90..566	CDD:222983	166/491 (34%)
		BACK	187..288	CDD:421692	39/100 (39%)
		KELCH repeat	377..420	CDD:276965	18/42 (43%)
		KELCH repeat	424..468	CDD:276965	14/43 (33%)
		KELCH repeat	471..526	CDD:276965	13/55 (24%)
		KELCH repeat	528..572	CDD:276965	20/44 (45%)
		KELCH repeat	575..620	CDD:276965	14/52 (27%)
		Kelch	587..631	CDD:128874	13/52 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820