Protein Alignment CG9426 and Klhl4

DIOPT Version :10

• Sequence 1: NP_609616.1
• Gene: CG9426 / 34719
• FlyBaseID: FBgn0032485
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_766369.2
• Gene: Klhl4 / 237010
• MGIID: 2442829
• Length: 717
• Species: Mus musculus
• Alignment Length: 597
• Identity: 193/597 - (32%)
• Similarity: 290/597 - (48%)
• Gaps: 72/597 - (12%)

  Fly    59 SYCNAQYPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQ 123
            |..:|.|   .|..:....::.:.|||.:|||...:.|||.||||.|.||.|||..:  :.|.:|
Mouse   160 SRSHADY---TLCKMESYLKERKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTND--VLEARQ 219

  Fly   124 KSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNAL 188
            :.|.:..:|.:.|:.|:.:.|||..::.:..::.||:||.:|||.:|:|.||.||.::||.||.|
Mouse   220 EEVKIEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCL 284

  Fly   189 GILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAAL 253
            ||..|.:|..|..|...|..:...:|..|....|||..|...:|:||.|:.:.|..|..:|.|.:
Mouse   285 GIRSFGDAQGCMELQNVAHKYAMEHFIDVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALM 349

  Fly   254 RWIKHDVTQRRCYVFDVLSHVRMALVPVKVIDKALKD-----------DCRDM---SVKIALRSI 304
            :|:.||...|:..:..:||::|:.|:..::    |.|           :|:.:   ::|..|
Mouse   350 QWVGHDAQARQRDLAKLLSYIRLPLLSPQL----LADLENSSFFSGNLECQKLLMEAMKYHL--- 407

  Fly   305 CRDIASKRGQLVPLRVCPRQLAKKNIYIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWTETAP 369
               :..:|..|...|..||:.....:|.:||.......|         |:.|:|:....|.....
Mouse   408 ---LPERRSMLQSPRTKPRKSTVGALYAVGGMDAAKGTT---------TIEKYDLRTNSWIHIGT 460

  Fly   370 MEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNLF 434
            |...|:..||:.::.|:|||||..|.:.|...|.::|....|..:.||...|...|:.|:.|.::
Mouse   461 MSGRRLQFGVAVVDNKLYVVGGRDGLKTLNTVECFNPVTKTWVVMPPMSTHRHGLGVATLEGPMY 525

  Fly   435 AVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGG-----CTTTTRHLP 494
            ||||..|.....::|.:||:...|..:.||..||.::|||:....:|.:||     |      |.
Mouse   526 AVGGHDGWSYLNTVERWDPDGRQWNYVASMSTPRSTVGVVALNNRLYAIGGRDGSSC------LK 584

  Fly   495 DLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGG---------SSISQDILSSVERYSFD 550
            .:..|:|.|.:|:..|.|...|..:|||..:.|||||||         |.:|    ..||||...
Mouse   585 SMEFFDPHTNKWSLCAPMSKRRGGVGVATHNGYLYVVGGHDAPAPNHCSRLS----DCVERYDPK 645

  Fly   551 EDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDL 615
            .|.|:||..|:|||...||......|||.||        |.....:|.||.||...|.||.  ::
Mouse   646 GDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG--------YDGHTYLNTVESYDAQKDEWKE--EV 700

  Fly   616 PVSRSEAGAVVV 627
            ||:...|||.||
Mouse   701 PVNIGRAGACVV 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB_POZ_KLHL27_IPP	63..189	CDD:349565	48/125 (38%)
		PHA03098	78..558	CDD:222983	161/507 (32%)
		KELCH repeat	374..417	CDD:276965	14/42 (33%)
		KELCH repeat	421..465	CDD:276965	14/43 (33%)
		KELCH repeat	468..512	CDD:276965	14/48 (29%)
		KELCH repeat	516..561	CDD:276965	21/53 (40%)
		KELCH repeat	564..617	CDD:276965	17/52 (33%)
		Kelch	575..627	CDD:128874	19/51 (37%)
Klhl4	NP_766369.2	PHA03098	175..697	CDD:222983	180/560 (32%)
		KELCH repeat	465..508	CDD:276965	14/42 (33%)
		KELCH repeat	512..556	CDD:276965	14/43 (33%)
		KELCH repeat	559..602	CDD:276965	14/48 (29%)
		KELCH repeat	606..657	CDD:276965	22/54 (41%)
		KELCH repeat	659..698	CDD:276965	16/46 (35%)