DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9426 and KLHL18

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_005265058.2	Gene:	KLHL18 / 23276	HGNCID:	29120	Length:	584	Species:	Homo sapiens

Alignment Length:	605	Identity:	198/605 - (32%)
Similarity:	289/605 - (47%)	Gaps:	63/605 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 ASHRTNLPSYCNAQYPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPE 115
            |....:|..:..::.|.:....:.::|.|.:.|||.:..|....||||.||:|:..||.|||..:
Human     6 AEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTND 70

  Fly   116 LGLNEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCR 180
              :.|.||..:|:..:|...|..|::|.|.|...|.|.|||.||..|..|||..:.|.||.||..
Human    71 --MMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRE 133

  Fly   181 ELHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSE 245
            .||..|.||:.:|||...|..|..:|.:|:|.:|..|::.:|||..|...:.:|::.:.|.|.||
Human   134 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSE 198

  Fly   246 SQVFQAALRWIKHDVTQRRCYVFDVLSHVRMALV-PVKVIDKALKDD-------CRDMSVKIALR 302
            .|||:|||.|:::|..||..|:.::||::|:.|. |..:.|:..:||       |||      |.
Human   199 EQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRD------LV 257

  Fly   303 SICRD---IASKRGQLVPLRVCPR---QLAKKNIYIIGGSHRDTPRTWNSADCIF-----ETVAK 356
            ...:|   :..:|..|...|..||   .:|.. ||.:||        .|||...:     ..|..
Human   258 DEAKDYHLMPERRPHLPAFRTRPRCCTSIAGL-IYAVGG--------LNSAANFYAGDSLNVVEV 313

  Fly   357 FDIFRREWTETAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQNDVWQPIAPMIVPR 421
            ||.....|....||...|...||:.:||.:|.:||..|...|:..|.|:|:.|.|..:..|...|
Human   314 FDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKR 378

  Fly   422 CEFGLCTMG-----GNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIY 481
            .......||     |.::..||:.|:....|:|.|.||.|.|.::.||...|.:.||..|||.||
Human   379 SSVCFSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIY 443

  Fly   482 IVGG-----CTTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSSISQDIL 541
            :.||     ..::..|      :|..|..|:..|.|...||:.|.|.|...::|.||.. ....|
Human   444 VSGGHDGLQIFSSVEH------YNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYD-GSGFL 501

  Fly   542 SSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLS 606
            |..|.||...|:|..:..::..|:..::||:.|.||..||        |..|..:::||.|||.:
Human   502 SIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGG--------YDGQSNLSSVEMYDPET 558

  Fly   607 DTWKNCPDLPVSRSEAGAVV 626
            |.|...  .|::..|.|..|
Human   559 DCWTFM--APMACHEGGVGV 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	43/105 (41%)
		PHA03098	78..558	CDD:222983	173/508 (34%)
		BACK	187..289	CDD:285009	38/102 (37%)
		Kelch	330..384	CDD:128874	16/58 (28%)
		KELCH repeat	374..417	CDD:276965	15/42 (36%)
		Kelch	385..431	CDD:128874	14/50 (28%)
		KELCH repeat	421..465	CDD:276965	15/48 (31%)
		Kelch	<447..478	CDD:128874	13/30 (43%)
		Kelch_6	467..516	CDD:290672	16/53 (30%)
		KELCH repeat	468..512	CDD:276965	15/48 (31%)
		Kelch_1	515..557	CDD:279660	15/41 (37%)
		KELCH repeat	516..561	CDD:276965	15/44 (34%)
		KELCH repeat	564..617	CDD:276965	17/52 (33%)
		Kelch	575..627	CDD:128874	17/52 (33%)
KLHL18	XP_005265058.2	BTB	28..131	CDD:279045	42/104 (40%)
		PHA03098	34..562	CDD:222983	189/559 (34%)
		BACK	140..242	CDD:285009	38/101 (38%)
		KELCH repeat	282..327	CDD:276965	12/53 (23%)
		Kelch	289..341	CDD:128874	16/60 (27%)
		Kelch_1	330..375	CDD:279660	15/44 (34%)
		KELCH repeat	331..374	CDD:276965	15/42 (36%)
		KELCH repeat	378..427	CDD:276965	15/48 (31%)
		Kelch	394..440	CDD:128874	16/45 (36%)
		KELCH repeat	430..474	CDD:276965	15/49 (31%)
		Kelch	441..486	CDD:128874	14/50 (28%)
		KELCH repeat	477..521	CDD:276965	15/44 (34%)
		Kelch_1	477..520	CDD:279660	15/43 (35%)
		Kelch_1	523..567	CDD:279660	17/53 (32%)
		KELCH repeat	524..567	CDD:276965	17/52 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820