Protein Alignment CG9426 and Klhl22

DIOPT Version :10

• Sequence 1: NP_609616.1
• Gene: CG9426 / 34719
• FlyBaseID: FBgn0032485
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_001365953.1
• Gene: Klhl22 / 224023
• MGIID: 1337995
• Length: 653
• Species: Mus musculus
• Alignment Length: 598
• Identity: 164/598 - (27%)
• Similarity: 271/598 - (45%)
• Gaps: 48/598 - (8%)

  Fly    52 SHRTNLPSYCNAQYPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPEL 116
            ||..| .:|.:.|:...:|..|..||:.....||.::.....:.|||.:|:|:..||..||..
Mouse    39 SHCVN-NTYRSTQHSQALLRGLLALRDSGILFDVVLVVEGKHIEAHRILLAASCDYFRGMFAG-- 100

  Fly   117 GLNEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRE 181
            ||.|::|:.|::|.:..:.:..:|.||||...|::.|||||.|.||..||:.|::..||:||...
Mouse   101 GLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSW 165

  Fly   182 LHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSES 246
            :...|.|.:.|.|:..:...|.:....::..||.|.:..|::.:.|...:..||:|..|.|..|:
Mouse   166 VDEENILDVYRLADLFDLNHLTQQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCET 230

  Fly   247 QVFQAALRWIKHDVTQRRCYVFD------VLSHVRMALVPVKVI----DKALKDDCRDMSVKIAL 301
            :|::.||.: .:.:.|.:.....      :|..||..|:..:|:    ||......|| :|..||
Mouse   231 EVYEGALLY-HYSLEQVQADQISLNEPPKLLETVRFPLMEAEVLQRLHDKLGPSPLRD-TVASAL 293

  Fly   302 RSICRDIASKRGQLVPLRVCPRQLAKKNIYII---GGSHRDTPRTWNSADCIFETVAKF-DIFRR 362
            .....:|      |.|....|:...:.:...:   ||.| .||.|      |....||: :....
Mouse   294 MYHRNEI------LQPSLQGPQTELRSDFQCVVGFGGIH-STPST------ILSDQAKYLNPLLG 345

  Fly   363 EWTE-TAPMEVGRILPGVSALNGKIYVVGGERGSQ-ILANGEV--YDPQNDVWQPIAPMIVPRCE 423
            ||.. ||.:.......|::.||..:|::||:...| ..|....  |||:::.|..|..:.....:
Mouse   346 EWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHAD 410

  Fly   424 FGLCTMGGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGGCTT 488
            ..:|.:|..::||.|....:...::|.|||..:.|..:..:.:..::....:.:|.:||..| ..
Mouse   411 LCVCVVGKYIYAVAGRDYHNDLSAVERYDPATNSWDYVAPLKKEVYAHAGTTLQGKMYITCG-RR 474

  Fly   489 TTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSS----ISQDILSSVERYSF 549
            ...:|.:...::|.:..|:.||.....|...|:|.|...|:|:|||:    ..:|: ..|..||.
Mouse   475 GEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMAALLDKLFVIGGSNNDAGYRRDV-HQVACYSC 538

  Fly   550 DEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPD 614
            ...:|::||.|......|.:...|..:||.||.     :..|...| ..|..||...|.|:..|.
Mouse   539 TSRQWSSVCPLPAGHGEPGIAVLDSRIYVLGGR-----SHNRGSRT-GYVHIYDMEKDCWEEGPQ 597

  Fly   615 LPVSRSEAGAVVV 627
            |..|.|...|.|:
Mouse   598 LNNSISGLAACVL 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB_POZ_KLHL27_IPP	63..189	CDD:349565	44/125 (35%)
		PHA03098	78..558	CDD:222983	133/501 (27%)
		KELCH repeat	374..417	CDD:276965	13/45 (29%)
		KELCH repeat	421..465	CDD:276965	10/43 (23%)
		KELCH repeat	468..512	CDD:276965	9/43 (21%)
		KELCH repeat	516..561	CDD:276965	16/48 (33%)
		KELCH repeat	564..617	CDD:276965	15/52 (29%)
		Kelch	575..627	CDD:128874	16/51 (31%)
Klhl22	NP_001365953.1	BTB_POZ_KLHL22	46..170	CDD:349560	44/125 (35%)
		PHA03098	71..611	CDD:222983	154/565 (27%)
		BACK_KLHL22	166..269	CDD:350536	24/103 (23%)
		KELCH repeat	313..354	CDD:276965	13/47 (28%)
		KELCH repeat	359..404	CDD:276965	13/44 (30%)
		KELCH repeat	408..452	CDD:276965	10/43 (23%)
		KELCH repeat	455..500	CDD:276965	9/45 (20%)
		KELCH repeat	502..550	CDD:276965	16/48 (33%)
		KELCH repeat	553..599	CDD:276965	14/51 (27%)