DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9426 and ivns-1

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_510109.1	Gene:	ivns-1 / 181410	WormBaseID:	WBGene00006493	Length:	817	Species:	Caenorhabditis elegans

Alignment Length:	739	Identity:	158/739 - (21%)
Similarity:	256/739 - (34%)	Gaps:	222/739 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQ--KSVVL--- 128
            :|..||..|.....||..:......:..|:.||:|.|.....||..|   ||..|  ||...
Worm    80 LLDRLNTFRRNRELCDAVLFVKEREIFVHKVVLAAVSPALLDMFNEE---NESSQDEKSPTSSSP 141

  Fly   129 ---HTI-----DGDILH------------------------------ILLDFIYTGRCEITQSNV 155
               ||.     :|::.|                              .|::|.||...||:...|
Worm   142 TNGHTNGITNGNGEVAHENGAPVSAQKPQKSSTTFYEFSQTDFECFEALVNFAYTANLEISSRKV 206

  Fly   156 QELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTLE 220
            .||...|..||:..|:..|..:|...|..||.:||.|.|..||...|......|:..||.::..:
Worm   207 AELYKTAYALQMIPVIRACAAYLAENLQLSNCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVND 271

  Fly   221 D-EFLETP--------------------------------------------------------- 227
            . ||.:.|
Worm   272 SKEFTQLPVIQVRIIVPAEDGKVTNNANNNGGLAEMALFYFQNMPHDRAEHSIDLLTCKTHILYM 336

  Fly   228 ---------------------------------------QTLLSQLLN----------------- 236
                                                   .|....::|
Worm   337 EENHLADCIEMDERSSVGSCDIIQDYKKSGKDRKDVAKAMTAQEPIINSVVQHRVNGAVPVRLNA 401

  Fly   237 SELLRVDSESQVFQAA------------LRWIKHDVTQRRCYVFDVLSHVRMALVPVKVID---- 285
            |.|..:::.::..::|            .|.|....|..:.:|..|:.:.|:.::.:::.|
Worm   402 SRLPNMNASNESLESAGTDDSDPQDTIEARLISTHQTAPQYWVALVVLYRRLCVLSLQLTDNEEL 466

  Fly   286 -KALKDDCRDMSVKIALRSICRDIASKRGQLVPLRVCPR-----QLAKKNIYIIGGSHRDTPRTW 344
             :..::.|...|.|.||.|.......|:.:.:.....||     ......|::.||        :
Worm   467 LRTKREPCPVDSQKAALLSRLISCTGKQQKPLECMSAPRCSIGASFLNGKIFVCGG--------Y 523

  Fly   345 NSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQND 409
            :..:|: .:|.::|:...:|...|.|:..|.....:...||::.|.|..|:..|.:.|:|||:.|
Worm   524 DRGECL-RSVEEYDVVNGKWRNVAKMKAERGRFDCTIHGGKVFAVAGSNGNNDLKSCEIYDPKAD 587

  Fly   410 VWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYD-----PEQDLWKLMGSMPQPRF 469
            ||.|:..:...||..|..|:...::.:||.....:....|..|     .|:..|:.|.||..||:
Worm   588 VWAPLPNLATARCHNGCATIDNYVYCIGGSFDQKVLKDCERLDTTKLGTEEAEWEPMASMEHPRY 652

  Fly   470 SMGVVSFEGLIYIVGGCTTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGS 534
            ..||.:::||:...|||...| .:..:.:|:|.|..|.:|.:::.||....|||:...|||:||.
Worm   653 QAGVCTWKGLVVAAGGCDRWT-CMDSVEAFDPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGGH 716

  Fly   535 SISQDILSSVERYSFDEDKWTTVCALNVPRA-IPAVVAADGLLYVAGGDQPCEVNFYRAQVTINA 598
            ..:|. |.:||.......:|.....|..||| ..|||.|..:::..||              .|.
Worm   717 DGTQS-LDTVEILDSPSSQWRVGPTLTTPRANTHAVVTAGNVIFCIGG--------------FNG 766

  Fly   599 VECYDPLS---------DTWKNCP 613
            |:..|.:.         ..|::||
Worm   767 VKFLDTIELLENEQIGWRNWQHCP 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	36/148 (24%)
		PHA03098	78..558	CDD:222983	138/663 (21%)
		BACK	187..289	CDD:285009	25/232 (11%)
		Kelch	330..384	CDD:128874	10/53 (19%)
		KELCH repeat	374..417	CDD:276965	15/42 (36%)
		Kelch	385..431	CDD:128874	17/45 (38%)
		KELCH repeat	421..465	CDD:276965	12/48 (25%)
		Kelch	<447..478	CDD:128874	11/35 (31%)
		Kelch_6	467..516	CDD:290672	15/48 (31%)
		KELCH repeat	468..512	CDD:276965	14/43 (33%)
		Kelch_1	515..557	CDD:279660	15/41 (37%)
		KELCH repeat	516..561	CDD:276965	14/44 (32%)
		KELCH repeat	564..617	CDD:276965	14/60 (23%)
		Kelch	575..627	CDD:128874	8/48 (17%)
ivns-1	NP_510109.1	BTB_POZ	77..241	CDD:365784	41/163 (25%)
		PHA03098	183..735	CDD:222983	118/562 (21%)
		KELCH repeat	505..548	CDD:276965	9/51 (18%)
		KELCH repeat	552..596	CDD:276965	15/43 (35%)
		KELCH repeat	599..647	CDD:276965	11/47 (23%)
		KELCH repeat	651..695	CDD:276965	14/44 (32%)
		KELCH repeat	698..743	CDD:276965	15/45 (33%)
		Kelch_1	744..>774	CDD:366584	12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820