DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9426 and kel-20

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_491322.2	Gene:	kel-20 / 172012	WormBaseID:	WBGene00020030	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	615	Identity:	193/615 - (31%)
Similarity:	296/615 - (48%)	Gaps:	62/615 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GATAASHRTNLPS-----------------YCNAQYPFKVLSNLNQLREQSRFCDVEIIAGMATL 94
            |....|...:|||                 |.|:.:...||..|..|:.:...|||.:|.|...:
Worm     3 GGQEISDPMDLPSTSHDSADMFESRKPQSKYKNSHFANSVLQQLGGLKNRDVLCDVTLICGWKRI 67

  Fly    95 SAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELL 159
            :|||.||||.|.||.:||..::.  |...:.:.:..|:...|..|::|.|||...|..||||::|
Worm    68 NAHRVVLSACSPYFLSMFTSQMA--ECYMREINMEEIEPPTLEALIEFCYTGAIAIDDSNVQDIL 130

  Fly   160 AAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFL 224
            .||.:||::||...||::|.::|..||.|||..||:.|:|:.|..||..|...||..|..::||.
Worm   131 PAACLLQIHEVQTACCDYLKKQLDPSNCLGIRAFADTHSCKELLSSADEFALKNFSRVIGKEEFQ 195

  Fly   225 ETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYVFDVLSHVRMALVPVKVIDKALK 289
            ......|:.::.|:.|...||..||.|.::|::||:::|:.::..:|||||:.|...|.:...:.
Worm   196 MLTVESLTTIIKSDKLNAASEELVFSAVIQWVRHDISKRKTHLSMLLSHVRLPLCTPKFLVSVVS 260

  Fly   290 DDCRDMSVKIALRS--ICRDIA--SKRGQLVPL--------RVCPRQ--LAKKNIYIIGGSHRDT 340
            ::       |.::|  ..||:.  :|...|:|:        |..||:  ...:.:|.:||
Worm   261 EE-------ILVKSDPASRDLVDEAKNYLLLPVERPNMQGPRTKPRKPLQGSEVLYAVGG----- 313

  Fly   341 PRTWNSADCIFETVAKFDIFR--REWTETAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEV 403
               |.|.|.| .::.:.|..:  ..|...|||...|...||:.|...:|.|||..|...|.:.|.
Worm   314 ---WCSGDAI-ASIERLDPMKGGTTWKCVAPMGKRRCGVGVAVLENLLYAVGGHDGQSYLNSIER 374

  Fly   404 YDPQNDVW-QPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQP 467
            |||..:.| ..:||....|...|:....|:|:||||..|:.....:|.|||.::.|..:.||...
Worm   375 YDPMTNQWSSDVAPTATCRTSVGVAAFNGSLYAVGGQDGESCLDVVEKYDPRKNEWAKVASMGTR 439

  Fly   468 RFSMGVVSFEGLIYIVGGCTTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVG 532
            |..:.|....|.||.||| :.....|..:..::|...:|.|:..|.|.|..:|.||.|.|:|.||
Worm   440 RLGVSVSVVNGCIYAVGG-SNGPAPLNTVERYDPRVGKWEEVRPMLTKRKHLGTAVYDGYIYAVG 503

  Fly   533 GSSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTIN 597
            |...:.: |::.||||.:.|:|..|.|::..|:...|......||..||        :..|..:.
Worm   504 GRDTTTE-LNTAERYSVERDEWQPVVAMSNRRSGVGVAVVGEKLYAVGG--------FDGQTYLK 559

  Fly   598 AVECYDPLSDTWKNCPDLPVSRSEAGAVVV 627
            :||.:|..::.||....:...|...|..||
Worm   560 SVEIFDKDTNRWKTHSQMFYRRLGGGVGVV 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	41/105 (39%)
		PHA03098	78..558	CDD:222983	164/496 (33%)
		BACK	187..289	CDD:285009	35/101 (35%)
		Kelch	330..384	CDD:128874	16/55 (29%)
		KELCH repeat	374..417	CDD:276965	16/43 (37%)
		Kelch	385..431	CDD:128874	15/46 (33%)
		KELCH repeat	421..465	CDD:276965	15/43 (35%)
		Kelch	<447..478	CDD:128874	9/30 (30%)
		Kelch_6	467..516	CDD:290672	14/48 (29%)
		KELCH repeat	468..512	CDD:276965	12/43 (28%)
		Kelch_1	515..557	CDD:279660	17/41 (41%)
		KELCH repeat	516..561	CDD:276965	19/44 (43%)
		KELCH repeat	564..617	CDD:276965	12/52 (23%)
		Kelch	575..627	CDD:128874	12/51 (24%)
kel-20	NP_491322.2	PHA03098	56..572	CDD:222983	176/543 (32%)
		KELCH repeat	345..389	CDD:276965	16/43 (37%)
		KELCH repeat	393..437	CDD:276965	15/43 (35%)
		KELCH repeat	440..485	CDD:276965	13/45 (29%)
		KELCH repeat	487..531	CDD:276965	19/44 (43%)
		KELCH repeat	534..577	CDD:276965	12/50 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820