DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9426 and KBTBD12

DIOPT Version :10

Sequence 1:NP_609616.1 Gene:CG9426 / 34719 FlyBaseID:FBgn0032485 Length:627 Species:Drosophila melanogaster
Sequence 2:NP_997218.2 Gene:KBTBD12 / 166348 HGNCID:25731 Length:623 Species:Homo sapiens


Alignment Length:609 Identity:164/609 - (26%)
Similarity:269/609 - (44%) Gaps:100/609 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 QYPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVL 128
            |:...:|:.:..::|.:...||.:.|.......||.||:|.|.||:|||  ..||.|..|:.|:|
Human    12 QHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMF--TCGLLECNQREVIL 74

  Fly   129 HTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRF 193
            :.|..:.:.:||:::|....||..:|||.:..||..:|:.||...|.:::...:.|||.|||..|
Human    75 YDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYF 139

  Fly   194 AEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKH 258
            |:....|.|:..:..:::.:|..|:|.:|.||........|:.|:.|.:..|..:....|||:.|
Human   140 AKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNH 204

  Fly   259 DVTQRRCYVFDVLSHVRMALVPVKVIDKALK--------DDCRDMSVKIALRSICRDIASKRGQL 315
            :...|..::.::|..||:.||....:.:||:        .||.|: ::.|.::|      |..|.
Human   205 NKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDI-IQNAFKAI------KTPQQ 262

  Fly   316 VPLRVCPRQLAKKNIYIIGGSH---RDTPRTWNSADCIFETVAKFDIFRREWTETAPM---EVGR 374
            ..|.:.........:..||.:.   |...|::..|...::.|:     |:.:..::|.   .:|.
Human   263 HSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVS-----RKTYFISSPKYGEGLGT 322

  Fly   375 ILPGVSALNGKIYVVGGERGSQILA-----NGEVY---DPQNDVWQPIAPMIVPRCEFGLCTMG- 430
            :..||...|..| :|.||..:..|:     |.|:|   |..|..|:.            |||.. 
Human   323 VCTGVVMENNTI-IVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEK------------LCTAEF 374

  Fly   431 GNLFAVGGWIGDD---IGGSME---------C---YDPEQDLWKLMGSMPQPRFSMGVVSFEGLI 480
            ..|:|:|. |.:|   |||.|:         |   |..|:|.||.:..:|.......||:....:
Human   375 RELYALGS-IHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKL 438

  Fly   481 YIVGGCTTTTRHLPD---------LISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGG-SS 535
            |::|| .|....|||         |:.::|...:|:..|.|:.::.:...||::..:||:|| ..
Human   439 YVIGG-WTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGC 502

  Fly   536 ISQD------ILSSVERYSFDEDKWTTVCALNVPRAIPAVV---------AADGLLYVAGGDQPC 585
            :.||      .|..||.|:.|.|.|..    ..|...|.:.         |.||.|||.||....
Human   503 VGQDKGQVRKCLDVVEIYNPDGDFWRE----GPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHGA 563

  Fly   586 EVNFYRAQVTINAVECYDPLSDTW 609
            :    |.:|....:...||..:.|
Human   564 D----RHEVISKEILELDPWENQW 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9426NP_609616.1 BTB_POZ_KLHL27_IPP 63..189 CDD:349565 41/124 (33%)
PHA03098 78..558 CDD:222983 147/533 (28%)
KELCH repeat 374..417 CDD:276965 14/50 (28%)
KELCH repeat 421..465 CDD:276965 18/59 (31%)
KELCH repeat 468..512 CDD:276965 13/52 (25%)
KELCH repeat 516..561 CDD:276965 15/51 (29%)
KELCH repeat 564..617 CDD:276965 14/55 (25%)
Kelch 575..627 CDD:128874 10/35 (29%)
KBTBD12NP_997218.2 BTB_POZ_KBTBD12 10..136 CDD:349585 42/125 (34%)
PHA03098 29..586 CDD:222983 161/592 (27%)
BACK_KBTBD12 128..227 CDD:350560 30/98 (31%)
KELCH repeat 375..422 CDD:276965 15/47 (32%)
Kelch 1 386..436 14/49 (29%)
KELCH repeat 426..479 CDD:276965 13/53 (25%)
Kelch 2 437..492 14/55 (25%)
KELCH repeat 482..535 CDD:276965 16/56 (29%)
Kelch 3 494..547 15/56 (27%)
KELCH repeat 541..587 CDD:276965 13/47 (28%)
Kelch 4 553..603 10/35 (29%)

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