DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9426 and Ipp

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_032415.2	Gene:	Ipp / 16351	MGIID:	96581	Length:	584	Species:	Mus musculus

Alignment Length:	578	Identity:	210/578 - (36%)
Similarity:	336/578 - (58%)	Gaps:	15/578 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 SYCNAQYPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQ 123
            |:.:.::...:|:.:|::|....||||::..|..|...||.||:|:|.||.|:|..  |:.|..:
Mouse    13 SFSSDKHAQLILAQMNKMRSGQHFCDVQLQVGKETFQVHRLVLAASSPYFAALFTG--GMKESSK 75

  Fly   124 KSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNAL 188
            ..|.:..::..|..:||||||||...|..:|||||:.|||||||.|||:.||:||..::...|.:
Mouse    76 DVVQILGVEAGIFQLLLDFIYTGVVNIAVTNVQELIVAADMLQLTEVVNLCCDFLKGQIDPQNCI 140

  Fly   189 GILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAAL 253
            |:.:|:|...|..|.:...|::|.:|..|...:|||...:..|.::|.||.|.::.|.|||.||:
Mouse   141 GLFQFSEQIACHDLLEFTENYIHVHFLEVHTGEEFLGLTKDQLIKILRSEELSIEDEYQVFLAAM 205

  Fly   254 RWIKHDVTQRRCYVFDVLSHVRMALVPVKVIDKALKDDCRDMSVKIALRSICRDI-----ASKRG 313
            :||..|:.:||.:|.:||..||..|:|.:.:.|.: :...|.::::||:::.::.     :.|..
Mouse   206 QWILKDLGKRRKHVVEVLDPVRFPLLPSQRLLKYI-EGVSDFNLRVALQTLLKEYCEVCKSPKEN 269

  Fly   314 Q----LVPLRVCPRQLAKKNIYIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWTETAPMEVGR 374
            :    |...:|.||:.|:|.:|.:||..|.....|:.:..: ..|.:||.|.:.||..:.:...|
Mouse   270 KFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRAL-SCVERFDTFSQYWTTVSSLHQAR 333

  Fly   375 ILPGVSALNGKIYVVGGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGW 439
            ...||:.:.|.:|.:|||:.|.|....|.|||....|..:|.|..|||..|:|...|.::|:|||
Mouse   334 CGLGVAVVGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGW 398

  Fly   440 IGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGGCTTTTRHLPDLISFNPVTK 504
            :|.:||.::|.:||:::.|:::|||...|:..|....:||||.|||.:.....|.....::|::|
Mouse   399 VGAEIGNTIERFDPDENKWEVVGSMAVSRYYFGCCEMQGLIYAVGGISNEGLELRSFEVYDPLSK 463

  Fly   505 EWNELARMQTARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAV 569
            .|:.|..|.|.|..:|||.|:..:|.:||.:.:||.|.:||:|||:|:||..|.::.||||....
Mouse   464 RWSPLPPMGTRRAYLGVAALNDCIYAIGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCA 528

  Fly   570 VAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEAGAVVV 627
            |..:|||||:||..  ..:.:.|..|:::||.|:|.||||....::..||.|.|..|:
Mouse   529 VTVNGLLYVSGGRS--SSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	49/105 (47%)
		PHA03098	78..558	CDD:222983	178/488 (36%)
		BACK	187..289	CDD:285009	36/101 (36%)
		Kelch	330..384	CDD:128874	14/53 (26%)
		KELCH repeat	374..417	CDD:276965	16/42 (38%)
		Kelch	385..431	CDD:128874	18/45 (40%)
		KELCH repeat	421..465	CDD:276965	18/43 (42%)
		Kelch	<447..478	CDD:128874	9/30 (30%)
		Kelch_6	467..516	CDD:290672	16/48 (33%)
		KELCH repeat	468..512	CDD:276965	14/43 (33%)
		Kelch_1	515..557	CDD:279660	19/41 (46%)
		KELCH repeat	516..561	CDD:276965	20/44 (45%)
		KELCH repeat	564..617	CDD:276965	20/52 (38%)
		Kelch	575..627	CDD:128874	20/51 (39%)
Ipp	NP_032415.2	BTB	27..131	CDD:279045	49/105 (47%)
		PHA03098	34..575	CDD:222983	201/546 (37%)
		BACK	139..241	CDD:285009	36/102 (35%)
		Kelch	290..343	CDD:128874	14/53 (26%)
		Kelch 1	296..343		11/47 (23%)
		KELCH repeat	333..376	CDD:276965	16/42 (38%)
		Kelch 2	344..390		18/45 (40%)
		Kelch	345..390	CDD:128874	18/44 (41%)
		KELCH repeat	380..424	CDD:276965	18/43 (42%)
		Kelch 3	391..437		16/45 (36%)
		Kelch	392..437	CDD:128874	16/44 (36%)
		KELCH repeat	427..473	CDD:276965	15/45 (33%)
		Kelch	438..485	CDD:128874	18/46 (39%)
		Kelch 4	439..485		17/45 (38%)
		KELCH repeat	475..520	CDD:276965	20/44 (45%)
		Kelch	486..533	CDD:128874	20/46 (43%)
		Kelch 5	487..533		20/45 (44%)
		KELCH repeat	523..574	CDD:276965	20/52 (38%)
		Kelch	534..584	CDD:128874	20/51 (39%)
		Kelch 6	535..583		19/49 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7209
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4309
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1982
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49630
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		oto93898
orthoMCL	1	0.900	-	-		OOG6_110419
Panther	1	1.100	-	-	LDO	PTHR24412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7939
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.870