DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9426 and Ivns1abp

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_473443.2	Gene:	Ivns1abp / 117198	MGIID:	2152389	Length:	642	Species:	Mus musculus

Alignment Length:	605	Identity:	155/605 - (25%)
Similarity:	270/605 - (44%)	Gaps:	66/605 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LSNLNQLREQSRFCDVEI-IAGMATLSAHRAVLSAASAYFEAMFRPEL---GLNEVKQKSVVLHT 130
            ::.||.||:..:||||.: :.|...| ||||||:..|.|...:|..:.   |::.||     |..
Mouse    19 VAKLNALRKSGQFCDVRLQVCGHEML-AHRAVLACCSPYLFEIFNSDSDPHGVSHVK-----LDD 77

  Fly   131 IDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAE 195
            ::.:.:.:||::.||.:.:..:..|:::.:||..|:::.|...|.::|...:..::.:....||.
Mouse    78 LNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFAS 142

  Fly   196 AHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDV 260
            ......|......::..:...::.|:|||:.|:..|..:|...:. :.|..:::...:.|::..:
Mouse   143 CMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVC-LPSNGKLYTKVINWVQRSI 206

  Fly   261 TQRRCYVFDVLSHVRMALVPV--KVID--------KALKDDCRDMSVKIALRSICRD-------- 307
            .:....:.:::..|:......  |::|        :....|  |..::...:...|:
Mouse   207 WENGDSLEELMEEVQTLYYSADHKLLDGNPLDGQAEVFGSD--DDHIQFVQKKPPRENGHKQISG 269

  Fly   308 ---------IASKRGQLVPLRVCPRQLAKKNIY-----------IIGGSHRDTPRTWNSADCIFE 352
                     .||.:......::...:....|.|           :|....|::|::..::.....
Mouse   270 SSTGCLSSPNASMQSPKHEWKIVASEKTSNNTYLCLAVLDSTFCVIFLHGRNSPQSSPTSTPKLS 334

  Fly   353 TVAKFDIFRREWTE--TAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQNDVWQPIA 415
            ....|::...|..|  .:||:..|...|.:.:|||:...||....:.|...|.|||..|.|..:|
Mouse   335 KSLSFEMQPDELLEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYDPHTDHWSFLA 399

  Fly   416 PMIVPRCEFGLCTMGGNLFAVGGWIG--DDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEG 478
            ||..||..|.:..:.|.|:.|||..|  ||:... |.|||..|.|..:..:...|.:.||.:..|
Mouse   400 PMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCG-EMYDPNIDDWTPVPELRTNRCNAGVCALNG 463

  Fly   479 LIYIVGGCTT-TTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSSISQDILS 542
            .:|||||... ..:.|.:...|:||||.|...|.:...|.|..|..|..|||::||:. |.:.|:
Mouse   464 KLYIVGGSDPYGQKGLKNCDVFDPVTKSWTSCAPLNIRRHQSAVCELGGYLYIIGGAE-SWNCLN 527

  Fly   543 SVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVECYDPLSD 607
            :||||:.:.:.||.:..:||.|....|...||.|:|.||        :.....|:.||.|||..:
Mouse   528 TVERYNPENNTWTLIAPMNVARRGAGVAVLDGKLFVGGG--------FDGSHAISCVEMYDPTRN 584

  Fly   608 TWKNCPDLPVSRSEAGAVVV 627
            .||...::...||.||...|
Mouse   585 EWKMMGNMTSPRSNAGITTV 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	33/109 (30%)
		PHA03098	78..558	CDD:222983	128/526 (24%)
		BACK	187..289	CDD:285009	15/111 (14%)
		Kelch	330..384	CDD:128874	11/66 (17%)
		KELCH repeat	374..417	CDD:276965	15/42 (36%)
		Kelch	385..431	CDD:128874	16/45 (36%)
		KELCH repeat	421..465	CDD:276965	16/45 (36%)
		Kelch	<447..478	CDD:128874	9/30 (30%)
		Kelch_6	467..516	CDD:290672	17/49 (35%)
		KELCH repeat	468..512	CDD:276965	17/44 (39%)
		Kelch_1	515..557	CDD:279660	17/41 (41%)
		KELCH repeat	516..561	CDD:276965	17/44 (39%)
		KELCH repeat	564..617	CDD:276965	16/52 (31%)
		Kelch	575..627	CDD:128874	16/51 (31%)
Ivns1abp	NP_473443.2	BTB	23..591	CDD:333434	149/586 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..281		1/23 (4%)
		KELCH repeat	358..401	CDD:276965	15/42 (36%)
		Kelch 1	369..415		16/45 (36%)
		KELCH repeat	405..450	CDD:276965	16/45 (36%)
		Kelch 2	416..463		16/47 (34%)
		KELCH repeat	453..498	CDD:276965	17/44 (39%)
		Kelch 3	465..512		17/46 (37%)
		KELCH repeat	502..545	CDD:276965	17/43 (40%)
		Kelch 4	513..559		17/46 (37%)
		KELCH repeat	549..593	CDD:276965	16/51 (31%)
		Kelch 5	561..606		17/52 (33%)
		Kelch_1	595..635	CDD:279660	5/10 (50%)
		KELCH repeat	596..635	CDD:276965	5/9 (56%)
		Kelch 6	608..642
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820