DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9426 and IVNS1ABP

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_011507381.1	Gene:	IVNS1ABP / 10625	HGNCID:	16951	Length:	649	Species:	Homo sapiens

Alignment Length:	613	Identity:	154/613 - (25%)
Similarity:	272/613 - (44%)	Gaps:	75/613 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LSNLNQLREQSRFCDVEI-IAGMATLSAHRAVLSAASAYFEAMFRPEL---GLNEVKQKSVVLHT 130
            ::.||.||:..:||||.: :.|...| ||||||:..|.|...:|..:.   |::.||     ...
Human    19 VAKLNALRKSGQFCDVRLQVCGHEML-AHRAVLACCSPYLFEIFNSDSDPHGISHVK-----FDD 77

  Fly   131 IDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAE 195
            ::.:.:.:||::.||.:.:..:..|:::.:||..|:::.|...|.::|...:..::.:....||.
Human    78 LNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFAS 142

  Fly   196 AHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDV 260
            ......|......::..:...::.|:|||:.|:..|..:|...:. :.|..:::...:.|::..:
Human   143 CMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVC-LPSNGKLYTKVINWVQRSI 206

  Fly   261 TQRRCYVFDVLSHVRMALVPV--KVIDKAL-----------KDDCRDMSVKIA------------ 300
            .:....:.:::..|:......  |::|..|           .|..:.:.|.||
Human   207 WENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQVHIAQSEKKPPRENGH 271

  Fly   301 ----------LRSICRDIASKRGQLVPLRVCPRQLAKKNIY----IIGG-------SHRDTPRTW 344
                      |.|....:.|.:.:   .::...:....|.|    ::.|       ..|::|::.
Human   272 KQISSSSTGCLSSPNATVQSPKHE---WKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSS 333

  Fly   345 NSADCIFETVAKFDIFRREWTE--TAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQ 407
            .::.........|::.:.|..|  .:||:..|...|.:.:|||:...||....:.|...|.|:|.
Human   334 PTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPH 398

  Fly   408 NDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIG--DDIGGSMECYDPEQDLWKLMGSMPQPRFS 470
            .|.|..:|||..||..|.:..:.|.|:.|||..|  ||:... |.||...|.|..:..:...|.:
Human   399 TDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCG-EMYDSNIDDWIPVPELRTNRCN 462

  Fly   471 MGVVSFEGLIYIVGGCTT-TTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGS 534
            .||.:..|.:|||||... ..:.|.:...|:||||.|...|.:...|.|..|..|..|||::||:
Human   463 AGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA 527

  Fly   535 SISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAV 599
            . |.:.|::||||:.:.:.||.:..:||.|....|...:|.|:|.||        :.....|:.|
Human   528 E-SWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGG--------FDGSHAISCV 583

  Fly   600 ECYDPLSDTWKNCPDLPVSRSEAGAVVV 627
            |.|||..:.||...::...||.||...|
Human   584 EMYDPTRNEWKMMGNMTSPRSNAGIATV 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	32/109 (29%)
		PHA03098	78..558	CDD:222983	128/534 (24%)
		BACK	187..289	CDD:285009	16/114 (14%)
		Kelch	330..384	CDD:128874	11/66 (17%)
		KELCH repeat	374..417	CDD:276965	14/42 (33%)
		Kelch	385..431	CDD:128874	15/45 (33%)
		KELCH repeat	421..465	CDD:276965	15/45 (33%)
		Kelch	<447..478	CDD:128874	8/30 (27%)
		Kelch_6	467..516	CDD:290672	17/49 (35%)
		KELCH repeat	468..512	CDD:276965	17/44 (39%)
		Kelch_1	515..557	CDD:279660	17/41 (41%)
		KELCH repeat	516..561	CDD:276965	17/44 (39%)
		KELCH repeat	564..617	CDD:276965	15/52 (29%)
		Kelch	575..627	CDD:128874	16/51 (31%)
IVNS1ABP	XP_011507381.1	BTB	22..126	CDD:279045	32/109 (29%)
		PHA03098	23..645	CDD:222983	153/609 (25%)
		BACK	134..229	CDD:197943	13/95 (14%)
		KELCH repeat	365..408	CDD:276965	14/42 (33%)
		Kelch	376..422	CDD:128874	15/45 (33%)
		KELCH repeat	416..458	CDD:276965	13/42 (31%)
		Kelch	423..470	CDD:128874	15/47 (32%)
		Kelch_1	460..506	CDD:279660	17/45 (38%)
		KELCH repeat	460..505	CDD:276965	17/44 (39%)
		KELCH repeat	509..552	CDD:276965	17/43 (40%)
		Kelch	521..566	CDD:128874	16/45 (36%)
		KELCH repeat	556..600	CDD:276965	15/51 (29%)
		Kelch	567..613	CDD:128874	17/53 (32%)
		Kelch_1	602..642	CDD:279660	5/10 (50%)
		KELCH repeat	603..642	CDD:276965	5/9 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820