DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and LRRC4B

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001073926.1	Gene:	LRRC4B / 94030	HGNCID:	25042	Length:	713	Species:	Homo sapiens

Alignment Length:	563	Identity:	127/563 - (22%)
Similarity:	200/563 - (35%)	Gaps:	173/563 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CHCKWNSGKKTADCRNLSLSGVP-------EYLSPE-----------------VQVLDLSHNHIF 85
            |.|. |...:.. |....|:.||       .||:.:                 :::|.||.|.:.
Human    61 CSCS-NQASRVI-CTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVR 123

  Fly    86 YLEENAF---------------LTT-------HLQNLQKLLIRNGTLKYLNQRSFTQLQILIELD 128
            .:|..||               |||       :|..|::|.:||..::.:...:|.::..|..||
Human   124 KIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLD 188

  Fly   129 LSN------------NLLVDL------------LPNVFDCLSKVRAIFLNGNLLQALRHGVFRNL 169
            |..            ..||:|            :||: ..|.::..:.|:||.|..:|.|.|:.|
Human   189 LGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNL-TALVRLEELELSGNRLDLIRPGSFQGL 252

  Fly   170 KYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVENPWNCTC 234
            ..|.|:.|...::.:|:..||..:..|.::.|.:|.|..|..:.|..|.:|..:.|..|||:|.|
Human   253 TSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNC 317

  Fly   235 DLQMFRDFVIGMNLY---TPPTS------CHYPLQLRGRLWIEDQPEAFAC-KPKIVYPTLSTSI 289
            |       |:.::.:   |.|::      ||.|..|:||...|.....|.| .|.||.|  .|.:
Human   318 D-------VLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEP--PTDL 373

  Fly   290 N-TSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDV 353
            | |......|.||. |:..|.:.|...|....:..       ..|:.|.:|           ||
Human   374 NVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHG-------SYRVRISVL-----------HD- 418

  Fly   354 FVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQKDMERISLIDSNFFAIVCLIAMGFLSM 418
              ..|...|....|.|.|||:..|..|..:...::       .:|.:|.        :|.|....
Human   419 --GTLNFTNVTVQDTGQYTCMVTNSAGNTTASATL-------NVSAVDP--------VAAGGTGS 466

  Fly   419 S-----------------ILFSLVTCLIFKRFKQFHPGQHTYLQPTSLPVQSPG----------- 455
            .                 ..|:.||.    ...:..||:.. |||.....:.||
Human   467 GGGGPGGSGGVGGGSGGYTYFTTVTV----ETLETQPGEEA-LQPRGTEKEPPGPTTDGVWGGGR 526

  Fly   456 --------SEEATAISALSSGVIRESKIVLDPLSAINEPSNKN 490
                    |...||.:..||....::..|  |::.:.|.:.|:
Human   527 PGDAAGPASSSTTAPAPRSSRPTEKAFTV--PITDVTENALKD 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	11/45 (24%)
		LRR_8	99..158	CDD:290566	18/82 (22%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	10/46 (22%)
		LRR_8	146..206	CDD:290566	17/59 (29%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		TPKR_C2	228..277	CDD:301599	18/58 (31%)
		IG_like	294..390	CDD:214653	21/95 (22%)
		Ig	296..387	CDD:143165	21/90 (23%)
LRRC4B	NP_001073926.1	LRRNT	57..90	CDD:214470	7/30 (23%)
		LRR	<76..297	CDD:227223	50/221 (23%)
		LRR 1	87..108		2/20 (10%)
		leucine-rich repeat	88..111	CDD:275380	2/22 (9%)
		LRR 2	111..132		7/20 (35%)
		leucine-rich repeat	112..135	CDD:275380	7/22 (32%)
		LRR 3	135..156		3/20 (15%)
		leucine-rich repeat	136..159	CDD:275380	4/22 (18%)
		LRR 4	159..180		5/20 (25%)
		leucine-rich repeat	160..183	CDD:275380	5/22 (23%)
		LRR 5	183..205		4/21 (19%)
		leucine-rich repeat	184..208	CDD:275380	5/23 (22%)
		LRR 6	208..229		3/21 (14%)
		leucine-rich repeat	209..230	CDD:275380	4/21 (19%)
		LRR 7	230..251		7/20 (35%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR 8	254..275		6/20 (30%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		LRR 9	278..299		6/20 (30%)
		leucine-rich repeat	279..300	CDD:275380	6/20 (30%)
		LRRCT	311..361	CDD:214507	17/56 (30%)
		I-set	364..453	CDD:254352	28/119 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..551		12/54 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..713
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910