DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek4 and Tlr9

DIOPT Version :9

Sequence 1:NP_001260435.1 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_112455.2 Gene:Tlr9 / 81897 MGIID:1932389 Length:1032 Species:Mus musculus


Alignment Length:256 Identity:66/256 - (25%)
Similarity:97/256 - (37%) Gaps:64/256 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PEVQVLDLSHNHIFY----LEENAFLTTHLQNLQKLLIRNGTL-----KYLNQRS---------- 117
            |::|.||||:|...:    :..|....|||..||.|.:.:..:     .:||..|          
Mouse   546 PQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNG 610

  Fly   118 --------------FTQLQILIELDLSNNLLVDLLPNVFDCLSK--------------------- 147
                          |..|..|::||||.|.|..|.|...|.|.|                     
Mouse   611 MGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLS 675

  Fly   148 ----VRAIFLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTK 208
                :..:.|.||.|:||.:|...|...|.|:::..|.:||:....|.....|.::.|.:|.|..
Mouse   676 FLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKT 740

  Fly   209 LRVESFQDLT-KLTALSLVENPWNCTCDLQMFRDFVIGMNLYTP----PTSCHYPLQLRGR 264
            :....|..:. .||.|.:..||.:|.|. ..|.|.::.:....|    ...|..|.||:||
Mouse   741 VDRSWFGPIVMNLTVLDVRSNPLHCACG-AAFVDLLLEVQTKVPGLANGVKCGSPGQLQGR 800

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
kek4NP_001260435.1 leucine-rich repeat 75..99 CDD:275380 10/27 (37%)
LRR_8 99..158 CDD:290566 23/112 (21%)
leucine-rich repeat 100..123 CDD:275380 8/51 (16%)
leucine-rich repeat 124..147 CDD:275380 11/22 (50%)
LRR_8 146..206 CDD:290566 18/84 (21%)
leucine-rich repeat 148..171 CDD:275380 8/22 (36%)
leucine-rich repeat 172..195 CDD:275380 6/22 (27%)
leucine-rich repeat 196..219 CDD:275380 5/23 (22%)
TPKR_C2 228..277 CDD:301599 13/41 (32%)
IG_like 294..390 CDD:214653
Ig 296..387 CDD:143165
Tlr9NP_112455.2 leucine-rich repeat 43..64 CDD:275380
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 47..51
LRR 1 62..85
LRR_8 63..135 CDD:290566
leucine-rich repeat 65..88 CDD:275380
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 72..77
LRR 2 87..110
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 95..109
LRR 3 122..147
leucine-rich repeat 125..168 CDD:275380
LRR_8 143..211 CDD:290566
LRR 4 150..166
LRR 5 167..190
leucine-rich repeat 169..200 CDD:275380
Interaction with CpG-DNA. /evidence=ECO:0000250|UniProtKB:Q2EEY0 179..181
LRR_RI <194..373 CDD:238064
LRR 6 198..221
LRR_8 199..254 CDD:290566
leucine-rich repeat 201..221 CDD:275380
leucine-rich repeat 222..245 CDD:275380
LRR 7 223..242
LRR 8 243..268
leucine-rich repeat 246..285 CDD:275380
LRR 9 283..306
LRR_8 284..344 CDD:290566
leucine-rich repeat 286..309 CDD:275380
LRR 10 308..332
leucine-rich repeat 310..335 CDD:275380
LRR 11 333..356
leucine-rich repeat 336..365 CDD:275380
LRR 12 363..386
LRR 13 390..413
leucine-rich repeat 393..411 CDD:275380
LRR 14 415..440
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 430..462
LRR 15 471..495
leucine-rich repeat 477..498 CDD:275380
LRR_RI <490..>641 CDD:238064 25/94 (27%)
LRR_8 497..556 CDD:290566 6/9 (67%)
LRR 16 497..520
leucine-rich repeat 499..523 CDD:275380
LRR 17 521..544