DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and Lrfn1

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001135393.1	Gene:	Lrfn1 / 80749	MGIID:	2136810	Length:	766	Species:	Mus musculus

Alignment Length:	400	Identity:	89/400 - (22%)
Similarity:	149/400 - (37%)	Gaps:	69/400 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LALIFRSASADWLLDC-GNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEEN 90
            |.|::..||..  ..| |.|.|:..:...|..|....|..||..:...|..|.|:.|.|..:...
Mouse    21 LLLLWAGASRG--QPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRR 83

  Fly    91 AFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNG 155
            .|  .::.:|..|.:...|:..:...:|..|:.|..|.|.:|.|.::..:....|..:|.:.|..
Mouse    84 DF--ANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGN 146

  Fly   156 NLLQALRHGVF-RNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTK 219
            |.::.:....| ..|..:..::|..|.|.::..:|...:..|:.:.||:|.:..:...:|..|.|
Mouse   147 NQIRKVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHK 211

  Fly   220 LTALSLVE--------------------------------NPWNCTCDLQMFRDFVIGMNLYTPP 252
            |..|.:..                                ||.:|.|:|...|......:|.|
Mouse   212 LVRLDMTSNRLHKLPPDGLFLRSQGGGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLET-- 274

  Fly   253 TSCHYPLQLRGRLWIEDQPEAFACKPKIVYPTL-STSINTSKENVTLICRVHGSPNTVIAWDYTN 316
              |..|..|..|.:.....|.|.|:|.::.... ..::....:.|:|.||..|.|..|:.|
Mouse   275 --CATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHW---- 333

  Fly   317 QVYESRSKPVKSLQKQRIYIELLREDESKIRKFGH-DVFVSRLTIVNARKSDEGVYTCLAENPGG 380
                  ..|...|        |.....:::|..|. ||.::.|       .|.|.:||:|.|..|
Mouse   334 ------VAPDGRL--------LGNSSRTRVRGDGTLDVTITTL-------RDSGTFTCIASNAAG 377

  Fly   381 KDSVHISVVV 390
            :.:..:.|.|
Mouse   378 EATAPVEVCV 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	5/23 (22%)
		LRR_8	99..158	CDD:290566	14/58 (24%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		LRR_8	146..206	CDD:290566	13/60 (22%)
		leucine-rich repeat	148..171	CDD:275380	5/23 (22%)
		leucine-rich repeat	172..195	CDD:275380	4/22 (18%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	14/48 (29%)
		IG_like	294..390	CDD:214653	24/96 (25%)
		Ig	296..387	CDD:143165	23/91 (25%)
Lrfn1	NP_001135393.1	LRR 1	66..87		6/22 (27%)
		leucine-rich repeat	67..90	CDD:275380	6/24 (25%)
		PPP1R42	70..226	CDD:411060	34/157 (22%)
		LRR 2	90..111		4/20 (20%)
		leucine-rich repeat	91..114	CDD:275380	5/22 (23%)
		LRR 3	114..135		5/20 (25%)
		leucine-rich repeat	115..138	CDD:275380	6/22 (27%)
		LRR 4	138..159		4/20 (20%)
		leucine-rich repeat	139..163	CDD:275380	5/23 (22%)
		LRR 5	163..184		4/20 (20%)
		leucine-rich repeat	164..187	CDD:275380	4/22 (18%)
		LRR 6	187..208		5/20 (25%)
		leucine-rich repeat	188..211	CDD:275380	6/22 (27%)
		LRR 7	211..232		3/20 (15%)
		leucine-rich repeat	212..230	CDD:275380	2/17 (12%)
		LRRCT	252..>284	CDD:214507	11/35 (31%)
		Ig	299..387	CDD:416386	24/112 (21%)
		Ig strand A	299..302	CDD:409353	0/2 (0%)
		Ig strand A'	306..310	CDD:409353	0/3 (0%)
		Ig strand B	316..324	CDD:409353	4/7 (57%)
		Ig strand C	330..335	CDD:409353	2/14 (14%)
		Ig strand C'	338..340	CDD:409353	0/1 (0%)
		Ig strand D	346..350	CDD:409353	0/3 (0%)
		Ig strand E	353..357	CDD:409353	1/3 (33%)
		Ig strand F	367..374	CDD:409353	3/6 (50%)
		Ig strand G	377..387	CDD:409353	2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..424
		FN3	426..500	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..601
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..742
		PDZ-binding	763..766
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43981
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910