DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and LRFN3

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_078785.1	Gene:	LRFN3 / 79414	HGNCID:	28370	Length:	628	Species:	Homo sapiens

Alignment Length:	385	Identity:	88/385 - (22%)
Similarity:	141/385 - (36%)	Gaps:	72/385 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109
            |.|:..|...:..|....|..||..|......|.|:.|.|..:.....  .::..|..|.:...|
Human    32 CRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDL--ANMTGLLHLSLSRNT 94

  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGV--------- 165
            ::::...:|..|:.|..|.|..|.|..|.......|..:|.:.|:.|.|.||..|.
Human    95 IRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLE 159

  Fly   166 -----FRNLKYL-----------HKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESF 214
                 :.||:.|           :.:.|..|.|.|:.|.||..:..|:::.:.:|.||.:..:..
Human   160 DLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPL 224

  Fly   215 QDLTKLTA-----------LSLVENPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIE 268
            .....|.|           |:...||.:|.|:|...|......:|    .:|..|..|.||.:..
Human   225 FSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDL----EACASPPALGGRYFWA 285

  Fly   269 DQPEAFACKPKIV---YPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQ 330
            ...|.|.|:|.:|   .|.|:.   .:.....|.||..|.|...:.|              .|.|
Human   286 VGEEEFVCEPPVVTHRSPPLAV---PAGRPAALRCRAVGDPEPRVRW--------------VSPQ 333

  Fly   331 KQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVV 390
            .:      |..:.|:.|.|.:    ..|.::.....|.|::||:|.|..|:.:..:.:.|
Human   334 GR------LLGNSSRARAFPN----GTLELLVTEPGDGGIFTCIAANAAGEATAAVELTV 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	4/23 (17%)
		LRR_8	99..158	CDD:290566	15/58 (26%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR_8	146..206	CDD:290566	19/84 (23%)
		leucine-rich repeat	148..171	CDD:275380	9/36 (25%)
		leucine-rich repeat	172..195	CDD:275380	8/33 (24%)
		leucine-rich repeat	196..219	CDD:275380	4/22 (18%)
		TPKR_C2	228..277	CDD:301599	14/48 (29%)
		IG_like	294..390	CDD:214653	20/95 (21%)
		Ig	296..387	CDD:143165	20/90 (22%)
LRFN3	NP_078785.1	LRR_8	59..119	CDD:290566	13/61 (21%)
		LRR 1	60..83		4/24 (17%)
		LRR_RI	<63..168	CDD:238064	23/106 (22%)
		leucine-rich repeat	63..84	CDD:275380	4/22 (18%)
		LRR 2	84..105		4/20 (20%)
		leucine-rich repeat	85..108	CDD:275380	5/22 (23%)
		LRR 3	108..129		6/20 (30%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		LRR 4	132..153		7/20 (35%)
		leucine-rich repeat	133..157	CDD:275380	7/23 (30%)
		LRR_8	157..216	CDD:290566	12/58 (21%)
		LRR 5	157..178		3/20 (15%)
		leucine-rich repeat	158..181	CDD:275380	3/22 (14%)
		LRR 6	181..202		7/20 (35%)
		leucine-rich repeat	182..205	CDD:275380	7/22 (32%)
		LRR 7	205..226		4/20 (20%)
		leucine-rich repeat	206..230	CDD:275380	4/23 (17%)
		leucine-rich repeat	242..253	CDD:275378	3/10 (30%)
		TPKR_C2	249..>281	CDD:301599	10/35 (29%)
		IG_like	302..383	CDD:214653	22/107 (21%)
		Ig	310..383	CDD:299845	20/96 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..430		1/2 (50%)
		fn3	424..502	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910