DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and TPBG

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001159864.1	Gene:	TPBG / 7162	HGNCID:	12004	Length:	420	Species:	Homo sapiens

Alignment Length:	297	Identity:	80/297 - (26%)
Similarity:	117/297 - (39%)	Gaps:	62/297 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 CKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFL-TTHLQNLQKLLIRNGTL 110
            |:.:...:|..|.|.:|:.||..|...|:.|.|:.|.:..|...||. ...|..|..|.:....|
Human    66 CECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRL 130

  Fly   111 KYLNQRSFTQLQILIELDLSNNLLVDLLPNVF-------DCLSKVRAIFLN-------------- 154
            ..:...:|..|..|.:||||:|.|.||.|..|       ...|.:..:.||
Human   131 DEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSF 195

  Fly   155 -GNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLT 218
             |.::.||..|  |.|:.|.::||..|..:.:.......:|.|..:.|.||.|..|...||::||
Human   196 EGMVVAALLAG--RALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLT 258

  Fly   219 KLTALSLVE--------------------------NPWNCTCDLQMF------RDFVIGMNLYTP 251
            .|.:|.|.:                          |||.|.|.:...      .:.|.|.:..|
Human   259 HLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLT- 322

  Fly   252 PTSCHYPLQLRGRLWIEDQPEAFACKPKIVYPTLSTS 288
               |.||.::|.|:.:|.......|.| |:.|:|.||
Human   323 ---CAYPEKMRNRVLLELNSADLDCDP-ILPPSLQTS 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	7/24 (29%)
		LRR_8	99..158	CDD:290566	20/80 (25%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	11/29 (38%)
		LRR_8	146..206	CDD:290566	18/74 (24%)
		leucine-rich repeat	148..171	CDD:275380	8/37 (22%)
		leucine-rich repeat	172..195	CDD:275380	4/22 (18%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		TPKR_C2	228..277	CDD:301599	14/54 (26%)
		IG_like	294..390	CDD:214653
		Ig	296..387	CDD:143165
TPBG	NP_001159864.1	LRRNT	61..95	CDD:214470	9/28 (32%)
		leucine-rich repeat	73..95	CDD:275380	8/21 (38%)
		LRR 1. /evidence=ECO:0000269\|PubMed:24582434	92..113		7/20 (35%)
		LRR_8	93..154	CDD:338972	19/60 (32%)
		leucine-rich repeat	96..119	CDD:275380	7/22 (32%)
		LRR 2. /evidence=ECO:0000269\|PubMed:24582434	116..139		4/22 (18%)
		leucine-rich repeat	120..143	CDD:275380	5/22 (23%)
		LRR 3. /evidence=ECO:0000269\|PubMed:24582434	141..163		11/21 (52%)
		leucine-rich repeat	144..167	CDD:275380	11/22 (50%)
		LRR 4. /evidence=ECO:0000269\|PubMed:24582434	172..204		5/31 (16%)
		leucine-rich repeat	175..211	CDD:275380	8/37 (22%)
		LRR 5. /evidence=ECO:0000269\|PubMed:24582434	209..232		5/22 (23%)
		LRR_8	211..270	CDD:338972	18/58 (31%)
		leucine-rich repeat	212..235	CDD:275380	4/22 (18%)
		LRR 6. /evidence=ECO:0000269\|PubMed:24582434	233..255		8/21 (38%)
		leucine-rich repeat	236..259	CDD:275380	9/22 (41%)
		LRR 7. /evidence=ECO:0000269\|PubMed:24582434	256..275		5/18 (28%)
		leucine-rich repeat	260..283	CDD:275380	3/22 (14%)
		LRRCT	294..345	CDD:214507	14/54 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910