DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek4 and Lrfn4

DIOPT Version :9

Sequence 1:NP_001260435.1 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_001102978.1 Gene:Lrfn4 / 688721 RGDID:1585286 Length:636 Species:Rattus norvegicus


Alignment Length:412 Identity:92/412 - (22%)
Similarity:142/412 - (34%) Gaps:97/412 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 LALIFRSASADWLLDCGNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENA 91
            |.|:..|.:|...|.   |.|:..|...:..|.:..|..||..:......|.|:.|.|..|....
  Rat     6 LLLLLASGAAACPLP---CVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGPPD 67

  Fly    92 FLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGN 156
            |  .::..|..|.:....:..:..|||..|:.|..|.|..|.||:|..:.......::.:.|:||
  Rat    68 F--RNMTGLVDLTLSRNAITRIGARSFGDLESLRSLHLDGNRLVELGSSSLRGPVNLQHLILSGN 130

  Fly   157 LLQALRHGVFRN-LKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKL 220
            .|..:..|.|.: |..|..:::..|.|..:.......:|.|..:.||:|.:..|....|..|::|
  Rat   131 QLGRIAPGAFDDFLDSLEDLDVSYNNLRQVPWAGIGSMPALHTLNLDHNLIDALPPGVFAQLSQL 195

  Fly   221 TALSLVE-------------------------------NPWNCTCDLQMFRDFVIGMNLYTPPTS 254
            :.|.|..                               ||.:|.|:|...|......:|.|    
  Rat   196 SRLDLTSNRLATLAPDPLFSRGRDAEASPSPLVLSFSGNPLHCNCELLWLRRLARPDDLET---- 256

  Fly   255 CHYPLQLRGR-LWIEDQPEAFACKPKIVYPTLSTSINTSKENVTLICRVHGSP------------ 306
            |..|..|.|| .|...:.| |:|:|.::............:..||.||..|.|            
  Rat   257 CASPPTLAGRYFWAVPEGE-FSCEPPLIARHTQRLWVLEGQRATLRCRALGDPVPTMHWVGPDDR 320

  Fly   307 ---NTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDE 368
               |:..||.:.|...|                                     :.:..|  .|.
  Rat   321 LVGNSSRAWAFPNGTLE-------------------------------------IGVTGA--GDA 346

  Fly   369 GVYTCLAENPGGKDSVHISVVV 390
            |.|||:|.||.|:.:..:.:.|
  Rat   347 GAYTCIATNPAGEATARVELRV 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_001260435.1 leucine-rich repeat 75..99 CDD:275380 6/23 (26%)
LRR_8 99..158 CDD:290566 16/58 (28%)
leucine-rich repeat 100..123 CDD:275380 6/22 (27%)
leucine-rich repeat 124..147 CDD:275380 7/22 (32%)
LRR_8 146..206 CDD:290566 15/60 (25%)
leucine-rich repeat 148..171 CDD:275380 7/23 (30%)
leucine-rich repeat 172..195 CDD:275380 3/22 (14%)
leucine-rich repeat 196..219 CDD:275380 7/22 (32%)
TPKR_C2 228..277 CDD:301599 16/49 (33%)
IG_like 294..390 CDD:214653 21/110 (19%)
Ig 296..387 CDD:143165 21/105 (20%)
Lrfn4NP_001102978.1 LRR 1 49..70 6/22 (27%)
leucine-rich repeat 50..73 CDD:275380 6/24 (25%)
PPP1R42 53..203 CDD:411060 40/151 (26%)
LRR 2 73..94 5/20 (25%)
leucine-rich repeat 74..97 CDD:275380 6/22 (27%)
LRR 3 97..118 7/20 (35%)
leucine-rich repeat 98..121 CDD:275380 7/22 (32%)
LRR 4 121..142 6/20 (30%)
leucine-rich repeat 122..146 CDD:275380 7/23 (30%)
LRR 5 146..169 3/22 (14%)
leucine-rich repeat 147..170 CDD:275380 3/22 (14%)
LRR 6 170..191 6/20 (30%)
leucine-rich repeat 171..194 CDD:275380 7/22 (32%)
LRR 7 194..215 3/20 (15%)
leucine-rich repeat 195..213 CDD:275380 3/17 (18%)
LRRCT 234..278 CDD:214507 16/48 (33%)
Ig 281..368 CDD:416386 21/125 (17%)
Ig strand A 281..284 CDD:409353 0/2 (0%)
Ig strand A' 288..291 CDD:409353 0/2 (0%)
Ig strand B 297..305 CDD:409353 4/7 (57%)
Ig strand C 311..316 CDD:409353 0/4 (0%)
Ig strand C' 319..321 CDD:409353 0/1 (0%)
Ig strand D 327..331 CDD:409353 2/3 (67%)
Ig strand E 334..338 CDD:409353 1/40 (3%)
Ig strand F 348..355 CDD:409353 4/6 (67%)
Ig strand G 358..368 CDD:409353 1/9 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..585
PDZ-binding 633..636
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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