DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek4 and Aspn

DIOPT Version :9

Sequence 1:NP_001260435.1 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_001165952.1 Gene:Aspn / 66695 MGIID:1913945 Length:373 Species:Mus musculus


Alignment Length:206 Identity:51/206 - (24%)
Similarity:99/206 - (48%) Gaps:31/206 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109
            |.|.    .:...|.:|.|:.||..:..:.:::||.:|.|..::||.|  ..|.:|..|::.|..
Mouse    72 CQCY----SRVVHCSDLGLTSVPNNIPFDTRMVDLQNNKIKEIKENDF--KGLTSLYALILNNNK 130

  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHK 174
            |..::.::|...:.|..|.||:|.|.::..|:...|:::|   ::.|.::.::...|:.:..||.
Mouse   131 LTKIHPKTFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELR---IHDNKVKKIQKDTFKGMNALHV 192

  Fly   175 IELKRNRLVS--IDAKAFVGV--------------------PLLSQIYLDNNELTKLRVESFQDL 217
            :|:..|.|.:  |:..||.||                    |.|.:::||.|:::.:.:|..:..
Mouse   193 LEMSANPLENNGIEPGAFEGVTVFHIRIAEAKLTSIPKGLPPTLLELHLDFNKISTVELEDLKRY 257

  Fly   218 TKLTALSLVEN 228
            .:|..|.|..|
Mouse   258 RELQRLGLGNN 268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_001260435.1 leucine-rich repeat 75..99 CDD:275380 8/23 (35%)
LRR_8 99..158 CDD:290566 15/58 (26%)
leucine-rich repeat 100..123 CDD:275380 5/22 (23%)
leucine-rich repeat 124..147 CDD:275380 8/22 (36%)
LRR_8 146..206 CDD:290566 18/81 (22%)
leucine-rich repeat 148..171 CDD:275380 3/22 (14%)
leucine-rich repeat 172..195 CDD:275380 10/44 (23%)
leucine-rich repeat 196..219 CDD:275380 5/22 (23%)
TPKR_C2 228..277 CDD:301599 1/1 (100%)
IG_like 294..390 CDD:214653
Ig 296..387 CDD:143165
AspnNP_001165952.1 LRRNT 68..97 CDD:214470 7/28 (25%)
leucine-rich repeat 77..96 CDD:275380 5/18 (28%)
LRR 1 96..117 7/22 (32%)
leucine-rich repeat 97..120 CDD:275380 8/24 (33%)
LRR_8 98..155 CDD:290566 18/58 (31%)
LRR 2 120..141 5/20 (25%)
leucine-rich repeat 121..144 CDD:275380 5/22 (23%)
LRR_RI <139..333 CDD:238064 32/133 (24%)
LRR 3 144..166 7/21 (33%)
leucine-rich repeat 145..165 CDD:275380 7/19 (37%)
Interaction with TGFB1 159..205 10/48 (21%)
leucine-rich repeat 166..189 CDD:275380 4/25 (16%)
LRR 5 189..212 8/22 (36%)
leucine-rich repeat 190..215 CDD:275380 10/24 (42%)
LRR_8 234..294 CDD:290566 10/35 (29%)
LRR 6 235..255 5/19 (26%)
leucine-rich repeat 236..259 CDD:275380 5/22 (23%)
LRR 7 259..280 4/10 (40%)
leucine-rich repeat 260..283 CDD:275380 4/9 (44%)
LRR 8 283..305
LRR 9 306..327
leucine-rich repeat 307..331 CDD:275380
LRR 10 328..349
leucine-rich repeat 332..359 CDD:275380
LRR 11 350..373
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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