DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and SLIT1

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_003052.2	Gene:	SLIT1 / 6585	HGNCID:	11085	Length:	1534	Species:	Homo sapiens

Alignment Length:	729	Identity:	149/729 - (20%)
Similarity:	260/729 - (35%)	Gaps:	178/729 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SADWLLDCGNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQN 99
            :|.|.|....|.........|.||....|..:|:.:....:.|:|:.|:|..:.:|.|  ..|:.
Human    24 AAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDF--AGLKQ 86

  Fly   100 LQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPN-VFDCLSKVRAIFLNGNLLQALRH 163
            |:.|.:....:..:.:.:|..::.|..|.|:.|.| .:||. :|.....:..:.|:.|.:||:..
Human    87 LRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL-HMLPELLFQNNQALSRLDLSENAIQAIPR 150

  Fly   164 GVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVEN 228
            ..||....|..::|.:|::..|:..||..:..|..:.|:||.:|.:.|.||..:.||....|..|
Human   151 KAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSN 215

  Fly   229 PWNCTCDLQMFRDFV-----IGMNLYTPPTSCHYPLQLRGRLWIEDQPEAFACK--------PKI 280
            ...|.|.|.....::     ||:.     |.|..|..|||....|.|...|:|.        |..
Human   216 HLFCDCHLAWLSQWLRQRPTIGLF-----TQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTC 275

  Fly   281 VYPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESRSK--PVKSLQKQRI--YIELLRE 341
            ...:.|.....:..|..:.||  |...|.|..:....:.|.|.:  .:||:.....  |.:|.|.
Human   276 TLSSGSCPAMCTCSNGIVDCR--GKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRI 338

  Fly   342 D--ESKIRKFGHDVF-----VSRLTIVNARKSD--EGVYTCLAENPGGKDSVHISVV-------- 389
            |  .::|.:...|.|     ::.|.:...:.:|  .||:       ||..::.:.::
Human   339 DLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVF-------GGLYTLQLLLLNANKINCI 396

  Fly   390 ---VQKDMERISLIDSNFFAIVCLIAMGFLSMSILFSLVTCLIFKRFKQFHPGQHTYLQPTSL-- 449
               ..:|::.:||:......|..|....|.|:..:.:|            |..|:.::...:|
Human   397 RPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTL------------HLAQNPFICDCNLKW 449

  Fly   450 --------PVQSPGSEEAT--AISALSSGVIRESKIVLDPLSAINEPSNKNYTLFKTSNS----- 499
                    |:::.|:..|:  .::....|.|:..|...........|..::|.|....||
Human   450 LADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCP 514

  Fly   500 ---------------------------------NGSE---------YMHTRNYKDVRLNSNTYTE 522
                                             |.:|         :....:.|.:.|::|..:|
Human   515 HKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSE 579

  Fly   523 NLD----------------NQAESISSRNRELYSNIAGDREKEELKQKDELDKDSRQSSLQS--- 568
            ..|                ||.|||.|   .::..:.|.|..        :.:::|.|.:.:
Human   580 IEDGAFEGAASVSELHLTANQLESIRS---GMFRGLDGLRTL--------MLRNNRISCIHNDSF 633

  Fly   569 TG------CSRKKGQIDELQPDLLPSTQPTALKNINETFGPSAKKAEVNPRSKYNTNVQKYLKEK 627
            ||      .|....||..:.|....:.|..:..|:           ..||   :|.|.|  |...
Human   634 TGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNL-----------LANP---FNCNCQ--LAWL 682

  Fly   628 YGSVRIKNISTKEP 641
            .|.:|.:.|.|..|
Human   683 GGWLRKRKIVTGNP 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	7/23 (30%)
		LRR_8	99..158	CDD:290566	13/59 (22%)
		leucine-rich repeat	100..123	CDD:275380	3/22 (14%)
		leucine-rich repeat	124..147	CDD:275380	8/23 (35%)
		LRR_8	146..206	CDD:290566	16/59 (27%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		TPKR_C2	228..277	CDD:301599	15/53 (28%)
		IG_like	294..390	CDD:214653	23/119 (19%)
		Ig	296..387	CDD:143165	22/103 (21%)
SLIT1	NP_003052.2	LRRNT	33..64	CDD:214470	6/30 (20%)
		leucine-rich repeat	43..62	CDD:275380	5/18 (28%)
		LRR_8	61..121	CDD:290566	14/61 (23%)
		LRR 1	62..83		6/22 (27%)
		leucine-rich repeat	63..86	CDD:275380	7/24 (29%)
		LRR_4	64..101	CDD:289563	9/38 (24%)
		LRR 2	86..107		3/20 (15%)
		LRR_RI	<87..220	CDD:238064	35/133 (26%)
		leucine-rich repeat	87..110	CDD:275380	3/22 (14%)
		LRR_8	109..169	CDD:290566	17/60 (28%)
		LRR 3	110..131		8/21 (38%)
		leucine-rich repeat	111..134	CDD:275380	8/23 (35%)
		LRR 4	134..155		5/20 (25%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		LRR 5	158..179		6/20 (30%)
		LRR_8	159..217	CDD:290566	18/57 (32%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		LRR 6	182..203		8/20 (40%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		leucine-rich repeat	207..334	CDD:275380	31/133 (23%)
		TPKR_C2	219..264	CDD:301599	14/49 (29%)
		LRRNT	282..313	CDD:214470	6/32 (19%)
		LRR 7	310..331		4/20 (20%)
		LRR_8	312..369	CDD:290566	12/56 (21%)
		LRR_4	334..373	CDD:289563	8/38 (21%)
		LRR 8	334..355		6/20 (30%)
		leucine-rich repeat	335..358	CDD:275380	6/22 (27%)
		LRR 9	358..379		4/27 (15%)
		leucine-rich repeat	359..379	CDD:275380	4/26 (15%)
		LRR 10	382..403		0/20 (0%)
		leucine-rich repeat	383..406	CDD:275380	1/22 (5%)
		LRR_8	389..441	CDD:290566	10/63 (16%)
		LRR 11	406..427		5/20 (25%)
		leucine-rich repeat	407..428	CDD:275380	5/20 (25%)
		leucine-rich repeat	431..528	CDD:275380	15/108 (14%)
		TPKR_C2	439..>469	CDD:301599	4/29 (14%)
		LRRNT	513..542	CDD:214470	0/28 (0%)
		leucine-rich repeat	529..566	CDD:275380	2/36 (6%)
		LRR 12	541..562		2/20 (10%)
		LRR_RI	<544..627	CDD:238064	16/93 (17%)
		LRR_8	544..601	CDD:290566	8/56 (14%)
		LRR 13	566..587		5/20 (25%)
		leucine-rich repeat	567..590	CDD:275380	5/22 (23%)
		LRR_8	590..649	CDD:290566	13/69 (19%)
		LRR 14	590..611		6/23 (26%)
		leucine-rich repeat	591..614	CDD:275380	6/25 (24%)
		LRR 15	614..635		4/28 (14%)
		LRR_4	615..654	CDD:289563	8/46 (17%)
		leucine-rich repeat	615..638	CDD:275380	5/30 (17%)
		LRR 16	638..659		4/20 (20%)
		leucine-rich repeat	639..660	CDD:275380	4/20 (20%)
		leucine-rich repeat	663..762	CDD:275380	12/50 (24%)
		LRRCT	671..719	CDD:214507	11/31 (35%)
		LRRNT	733..765	CDD:214470
		LRR_8	761..820	CDD:290566
		LRR 17	762..783
		leucine-rich repeat	763..785	CDD:275380
		LRR 18	785..806
		LRR_4	786..827	CDD:289563
		leucine-rich repeat	786..809	CDD:275380
		LRR 19	809..830
		leucine-rich repeat	810..830	CDD:275380
		LRR 20	833..854
		leucine-rich repeat	834..857	CDD:275380
LRRCT	866..915	CDD:214507
EGF_CA	927..962	CDD:238011
EGF_CA	966..1002	CDD:238011
EGF_CA	1005..1041	CDD:238011
EGF_CA	1044..1080	CDD:238011
EGF_CA	1085..1119	CDD:238011
EGF_CA	<1136..1163	CDD:238011
LamG	1189..1322	CDD:214598
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910