DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek4 and LINGO3

DIOPT Version :9

Sequence 1:NP_001260435.1 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_001094861.1 Gene:LINGO3 / 645191 HGNCID:21206 Length:592 Species:Homo sapiens


Alignment Length:567 Identity:125/567 - (22%)
Similarity:191/567 - (33%) Gaps:198/567 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 GNC--HCKWNSGKKTADCRNLSLSGVPEYLS------------------------PEVQVLDLSH 81
            |.|  .|:.....:...|....|:.||:.:.                        |.::.||||.
Human    23 GGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSE 87

  Fly    82 NHIFYLEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLS 146
            |.|.::|..||  .:|..|:.|.:|...||.:....||:|..|..||||.|.||.||...|..|.
Human    88 NAIAHVEPGAF--ANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLH 150

  Fly   147 KVRAIFLNGN------------------------------------------------------- 156
            .:|.:.:..|                                                       
Human   151 SLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLED 215

  Fly   157 ------------------LLQ----------------------------ALRH------------ 163
                              ||:                            ||||            
Human   216 QNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHN 280

  Fly   164 -------GVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLT 221
                   |.||:|..|.::.|....|..::.:||:|:..:..:.|.||.|:.|...:|..:..|.
Human   281 PISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLE 345

  Fly   222 ALSLVENPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIEDQP-----EAFAC-KPKI 280
            .|.:..||..|.|.|.........:|......:|..|.::||.. :.:.|     |.|.| ||||
Human   346 TLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDA-LRNLPDSVLFEYFVCRKPKI 409

  Fly   281 VYPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESK 345
            ....|.....|:.|:|..:||..|.|...:||      ...:.:||.:....|          ::
Human   410 RERRLQRVTATAGEDVRFLCRAEGEPAPTVAW------VTPQHRPVTATSAGR----------AR 458

  Fly   346 IRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQKD-----------MERISL 399
            :...|      .|.|.:||..|.|.|||:|.|.||.|:...::.|:.:           .|.::.
Human   459 VLPGG------TLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEPAANRTPGEAHNETLAA 517

  Fly   400 IDS--NFFAIVCLIAMG---FLSMSILFSLVTCLIFKRFKQFHPGQH 441
            :.:  :...|:...|||   ||.: :||..|...::.|.:    |||
Human   518 LRAPLDLTTILVSTAMGCITFLGV-VLFCFVLLFVWSRGR----GQH 559

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_001260435.1 leucine-rich repeat 75..99 CDD:275380 10/23 (43%)
LRR_8 99..158 CDD:290566 22/131 (17%)
leucine-rich repeat 100..123 CDD:275380 8/22 (36%)
leucine-rich repeat 124..147 CDD:275380 12/22 (55%)
LRR_8 146..206 CDD:290566 21/179 (12%)
leucine-rich repeat 148..171 CDD:275380 12/142 (8%)
leucine-rich repeat 172..195 CDD:275380 6/22 (27%)
leucine-rich repeat 196..219 CDD:275380 6/22 (27%)
TPKR_C2 228..277 CDD:301599 14/54 (26%)
IG_like 294..390 CDD:214653 26/95 (27%)
Ig 296..387 CDD:143165 25/90 (28%)
LINGO3NP_001094861.1 LRRNT 24..58 CDD:214470 6/33 (18%)
LRR 1 55..76 0/20 (0%)
LRR_8 57..138 CDD:290566 25/82 (30%)
LRR_4 59..95 CDD:289563 7/35 (20%)
leucine-rich repeat 59..79 CDD:275380 0/19 (0%)
LRR 2 79..100 9/22 (41%)
leucine-rich repeat 80..103 CDD:275380 10/24 (42%)
LRR 3 103..124 6/20 (30%)
leucine-rich repeat 104..127 CDD:275380 8/22 (36%)
LRR_RI 111..>286 CDD:238064 25/174 (14%)
LRR_8 127..>172 CDD:290566 14/44 (32%)
LRR 4 127..148 11/20 (55%)
leucine-rich repeat 128..151 CDD:275380 12/22 (55%)
LRR 5 151..172 2/20 (10%)
leucine-rich repeat 152..199 CDD:275380 2/46 (4%)
LRR 6 175..196 0/20 (0%)
LRR_8 198..258 CDD:290566 2/59 (3%)
leucine-rich repeat 200..223 CDD:275380 0/22 (0%)
LRR 7 207..228 0/20 (0%)
leucine-rich repeat 224..247 CDD:275380 2/22 (9%)
LRR_8 247..303 CDD:290566 10/55 (18%)
LRR 8 247..268 2/20 (10%)
leucine-rich repeat 248..271 CDD:275380 4/22 (18%)
LRR 9 271..292 2/20 (10%)
leucine-rich repeat 272..293 CDD:275380 3/20 (15%)
LRR 10 295..316 5/20 (25%)
leucine-rich repeat 296..319 CDD:275380 6/22 (27%)
LRR 11 319..340 6/20 (30%)
leucine-rich repeat 322..343 CDD:275380 6/20 (30%)
I-set 407..497 CDD:254352 31/111 (28%)
Ig 422..490 CDD:299845 25/89 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41933
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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