DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek4 and LRRN1

DIOPT Version :9

Sequence 1:NP_001260435.1 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_001311117.1 Gene:LRRN1 / 57633 HGNCID:20980 Length:716 Species:Homo sapiens


Alignment Length:741 Identity:144/741 - (19%)
Similarity:236/741 - (31%) Gaps:274/741 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 CHCK---WNSGKK------TADCRNLSLSGVPEYLSPEVQVLDLSHNHI---------------- 84
            |.|:   |.:.:.      |.||.:|.|:.:|..||.:.|||.|..|:|                
Human    36 CVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTEL 100

  Fly    85 -----------------------FYLEENA------FLTTHLQNLQKLLIRNGTLKYLNQRSFTQ 120
                                   .:||||.      :....|.|||:|.|.:..:..::..:|..
Human   101 DFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAG 165

  Fly   121 LQILIELDLSNNLL-------VDLLPNV-----------------FDCLSKVRAIF--------- 152
            |:.|:.|.|::|.|       .|..||:                 |..|:.:|::.         
Human   166 LKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDI 230

  Fly   153 ---------------------------------------LNGNLLQALRHGVFRNLKYLHKIELK 178
                                                   ||.|.:..::.|.|:|:..|.::.:.
Human   231 PGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGIN 295

  Fly   179 R-NRLVSID-------------------------AKAFVGVPLLSQIYLDNNELTKLRVESFQDL 217
            . ..|||:|                         ..||..||.|..:.|:||.|..:..::.:.|
Human   296 NMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESL 360

  Fly   218 TKLTALSLVENPWNCTCDLQMFRDFVIGMNLYTPPTS-CHYPLQLRG----RLWIEDQPEAFACK 277
            ..|..:|:..||..|.|.:.........:....|.:. |..|.:.:|    .:.|:|..|  .|.
Human   361 PNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSE--QCL 423

  Fly   278 PKIVYPTLSTSINTS-KENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLRE 341
            |.|.:.:....:|.. ...|.|.||....|...|.|          ..|:.:    :|.:|.| .
Human   424 PMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYW----------VTPIGN----KITVETL-S 473

  Fly   342 DESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQ---KDMERISLI--- 400
            |:.|:...|      .|.|.|.:..|.|.|||:|:|..|.|:...::.|.   .|..::..|   
Human   474 DKYKLSSEG------TLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTLLDGTQVLKIYVK 532

  Fly   401 --DSNFFAIVCLIAMGFLSMSILFSLVTCLIFKRFKQF--------HPGQHTYLQPT-------- 447
              :|:...:...:....::.::.:|..|..|......:        |....|:|||:        
Human   533 QTESHSILVSWKVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLT 597

  Fly   448 --------------------SLPVQSPGSEEATAISALSSGVIRESKIVLDPLSAINEPSNKNYT 492
                                :..|.....|.:||::|     :..|...:..|::|.....|.  
Human   598 VSNIHQQTQKSCVNVTTKNAAFAVDISDQETSTALAA-----VMGSMFAVISLASIAVYFAKR-- 655

  Fly   493 LFKTSNSNGSEYMHTRNYKDVRLNSNTYTENLDNQAESISSRNRELYSNI----AGDREKEELKQ 553
             ||..|.:.|...:.:....:.||                    |||..:    .||.||     
Human   656 -FKRKNYHHSLKKYMQKTSSIPLN--------------------ELYPPLINLWEGDSEK----- 694

  Fly   554 KDELDKDSRQSSLQSTGCSRKKGQID 579
                |||.        ....|..|:|
Human   695 ----DKDG--------SADTKPTQVD 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_001260435.1 leucine-rich repeat 75..99 CDD:275380 11/68 (16%)
LRR_8 99..158 CDD:290566 21/130 (16%)
leucine-rich repeat 100..123 CDD:275380 6/22 (27%)
leucine-rich repeat 124..147 CDD:275380 10/46 (22%)
LRR_8 146..206 CDD:290566 20/133 (15%)
leucine-rich repeat 148..171 CDD:275380 7/70 (10%)
leucine-rich repeat 172..195 CDD:275380 8/48 (17%)
leucine-rich repeat 196..219 CDD:275380 6/22 (27%)
TPKR_C2 228..277 CDD:301599 11/53 (21%)
IG_like 294..390 CDD:214653 26/95 (27%)
Ig 296..387 CDD:143165 26/90 (29%)
LRRN1NP_001311117.1 LRR_RI 13..273 CDD:238064 42/236 (18%)
leucine-rich repeat 54..73 CDD:275380 8/18 (44%)
LRR 1 73..95 6/21 (29%)
leucine-rich repeat 74..96 CDD:275380 6/21 (29%)
LRR 2 96..117 0/20 (0%)
leucine-rich repeat 97..120 CDD:275380 0/22 (0%)
LRR_8 119..179 CDD:290566 16/59 (27%)
LRR 3 120..141 4/20 (20%)
leucine-rich repeat 121..144 CDD:275380 5/22 (23%)
LRR 4 144..165 6/20 (30%)
leucine-rich repeat 145..168 CDD:275380 6/22 (27%)
LRR 5 168..189 5/20 (25%)
leucine-rich repeat 169..192 CDD:275380 6/22 (27%)
LRR 6 192..213 2/20 (10%)
leucine-rich repeat 193..216 CDD:275380 2/22 (9%)
LRR_8 216..275 CDD:290566 4/58 (7%)
LRR 7 216..237 1/20 (5%)
leucine-rich repeat 217..240 CDD:275380 1/22 (5%)
LRR_RI 240..>376 CDD:238064 25/135 (19%)
LRR 8 240..261 0/20 (0%)
leucine-rich repeat 241..264 CDD:275380 0/22 (0%)
LRR_8 263..323 CDD:290566 11/59 (19%)
LRR 9 264..285 5/20 (25%)
leucine-rich repeat 265..288 CDD:275380 6/22 (27%)
leucine-rich repeat 289..313 CDD:275380 5/23 (22%)
LRR_8 312..373 CDD:290566 13/60 (22%)
LRR 10 313..335 2/21 (10%)
leucine-rich repeat 314..335 CDD:275380 2/20 (10%)
LRR 11 338..359 5/20 (25%)
leucine-rich repeat 339..362 CDD:275378 6/22 (27%)
leucine-rich repeat 363..375 CDD:275378 4/11 (36%)
LRRCT 371..419 CDD:214507 10/47 (21%)
I-set 429..516 CDD:254352 27/107 (25%)
Ig 431..516 CDD:299845 27/105 (26%)
fn3 531..600 CDD:278470 9/68 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..716 9/35 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.