DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and Fili

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	806	Identity:	149/806 - (18%)
Similarity:	263/806 - (32%)	Gaps:	294/806 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPE-----------------------VQVLDLSHNHI-- 84
            |.|........|.|.:.:|..||..|:||                       :::||||.|.|
  Fly    46 CQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIET 110

  Fly    85 --------------FYLEENAFLTTH------LQNLQKLLIRNGTLKYLNQRSFTQLQILIELDL 129
                          ..|..|...:.|      |.||..|.:....::.::..:.:.|..|:||||
  Fly   111 LGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDL 175

  Fly   130 SNNLLVDLLPNVFDCLSKVRA-IFLNG-----------------------NLLQALRHGVFRNLK 170
            :||.:|.|..|.|..::.:.. :|.|.                       ||::.:|:..|..||
  Fly   176 TNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLK 240

  Fly   171 YLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVENPWN---C 232
            .|..:.::.|.:..:|..||.|:..|..:.|.:|.||.:..:....|:.||.|:|..|.::   .
  Fly   241 ELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPA 305

  Fly   233 TCDLQMF------------------RDFVIGMNLYT-------------------PPT------- 253
            ...|.:|                  |.||...:|.|                   .|.
  Fly   306 VAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQ 370

  Fly   254 --------SCHYPLQLRGRLWIEDQPEAFACKPKIVY-------------PTL------------ 285
                    |..:|:....:|::.|.|  ..|...:::             |.:
  Fly   371 SNSLQTLYSAQFPVDQLQKLYLGDNP--LQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALA 433

  Fly   286 -----------STSINTSKENVTLICRVHGSPNTVIAWDYTN-QVYE------SRSKPVKSLQKQ 332
                       :|::.::.:.|..:.......:.|.|...|. ..||      :|:..:..:.:|
  Fly   434 KEADDEELADEATAVASTDDGVAALAAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMDRQ 498

  Fly   333 RIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQKDMERI 397
            :|..::.|:.....||.        ||:      .||..||.|         ||..||
  Fly   499 QIGCDIWRDKVRTRRKL--------LTM------SEGEITCPA---------HIVTVV------- 533

  Fly   398 SLIDSNFFAIVCLIAMGFLSMSILFSLVTCLIFKRFKQFHPGQHTYLQPTSLPVQSPGSEEATAI 462
                   .|::..:.:..:.:|:|:.|  ..:.:|.|..|
  Fly   534 -------CAVITCLLVAMIGISVLYYL--RFVKRRRKLLH------------------------- 564

  Fly   463 SALSSGVIRESKIVLDPLSAINEPSN-------KNYTLFKTSNSNGSEYMHTRNYKDVRLNSNTY 520
               ..|.:|.||.:::....|.:..|       .:.||...::.||         ..:.||...:
  Fly   565 ---ERGPMRTSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNG---------LGMTLNYPHH 617

  Fly   521 TENLD-----NQAESISSRNRELYSNIAGDREKEE--LKQKDELDKDSRQSSLQSTGCSRKKGQI 578
            .:.|.     :||..:.|....      |:.|.::  |.|.|:|:.: |..:.|:.....:..:.
  Fly   618 AQTLQAHHHYHQAMPLQSHGGN------GNHEYQQTTLPQLDKLELE-RYLAAQTIANEYRALKP 675

  Fly   579 DEL-------QPDLL---------PST-------QPTALKNINETFGPSAKKAEVNPRSKYNTNV 620
            .||       :|:.|         |.|       |..:|.:.|.:.|||..     |.|....:|
  Fly   676 WELPVKEADDEPEHLYERFDHYEYPDTHTMSKLKQAASLNHSNSSAGPSPV-----PPSSGKPHV 735

  Fly   621 QKYLKEKYGSVRIKNISTKEPITGVD 646
            ... :.:....|:..|:|...:.|::
  Fly   736 VYVXRGRGTGERVSQINTDIEMVGLN 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	10/45 (22%)
		LRR_8	99..158	CDD:290566	18/82 (22%)
		leucine-rich repeat	100..123	CDD:275380	3/22 (14%)
		leucine-rich repeat	124..147	CDD:275380	11/22 (50%)
		LRR_8	146..206	CDD:290566	17/83 (20%)
		leucine-rich repeat	148..171	CDD:275380	7/46 (15%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	14/103 (14%)
		IG_like	294..390	CDD:214653	21/102 (21%)
		Ig	296..387	CDD:143165	20/97 (21%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	0/21 (0%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR_8	120..180	CDD:404697	15/59 (25%)
		leucine-rich repeat	122..145	CDD:275380	4/22 (18%)
		leucine-rich repeat	146..169	CDD:275380	3/22 (14%)
		LRR	<161..>354	CDD:227223	44/192 (23%)
		leucine-rich repeat	170..193	CDD:275380	11/22 (50%)
		leucine-rich repeat	194..217	CDD:275380	2/22 (9%)
		leucine-rich repeat	218..265	CDD:275380	12/46 (26%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	3/23 (13%)
		LRR_8	337..397	CDD:404697	8/61 (13%)
		leucine-rich repeat	339..360	CDD:275380	2/20 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910