DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek4 and lrrc24

DIOPT Version :9

Sequence 1:NP_001260435.1 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:XP_009297158.1 Gene:lrrc24 / 565790 ZFINID:ZDB-GENE-060503-496 Length:692 Species:Danio rerio


Alignment Length:524 Identity:119/524 - (22%)
Similarity:202/524 - (38%) Gaps:124/524 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 FDPCSISLKHLSLFLFKIYC--------------LALIFRSASADWLLDCGNCHCKWNSGKKTAD 57
            |.|.|.||.:.|  .|.::|              |.|:.....:..|.....|.|.    ..|.:
Zfish    76 FCPSSESLFYHS--FFPVFCSVFSEMNPGQMSAVLVLMLAQLCSTSLACPSGCRCY----SLTVE 134

  Fly    58 CRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQ 122
            |.::.:..:|:.::...|.:.|..|.|..:.:...  :.|..|..|.::|.::..|...:|..|.
Zfish   135 CGSIGIKEIPQGITQGTQTIFLQDNAIGQIRQRDL--SDLGQLHYLYLQNNSISTLEPGAFRSLG 197

  Fly   123 ILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDA 187
            :|:||.|:.|.:..:..:||..|..:|.::|.||.:..|....||.|:.|.::.|:.|.|..:..
Zfish   198 LLLELALNGNRIHLITADVFRGLDHLRILYLAGNQINRLEDYTFRGLQRLQELHLQENVLEVLGD 262

  Fly   188 KAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVENPWNCTCDLQMFRDFV--IGMNLYT 250
            :|.||:..|:.:.|..|.|..|...|.:.|..|..|.:.:|||.|.|.|...|.::  .|..|.:
Zfish   263 QALVGLSSLALLDLSRNNLRTLSPASLKPLVSLQVLRVTDNPWRCDCALHWLRGWINEEGQRLLS 327

  Fly   251 ----------PPTSCHYPLQLRGRLWIEDQPEAFACKPKIVYPTLSTSINTSK--ENVTLICRVH 303
                      ||...|..|       :|..|.:..|.|.:|  .|..|..|.:  |::.:.|:..
Zfish   328 SAERRMLCAEPPRLSHLSL-------VEVPPNSLVCIPPVV--QLEPSHLTVRLGESLRVSCQAS 383

  Fly   304 GSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESK---------------------IR 347
            |.|...:.|       ...|.....|..:.:..|:..:.:::                     ||
Zfish   384 GYPQPQVTW-------RKASHGKAQLSPRGLVQEVGMDGDTRNGGRLVTARPGGKGGPSSHGPIR 441

  Fly   348 KFGHD---------------VFVSRLTIVNARKSDEGVYTCLAENPGG--KDSVHISV------- 388
            ....|               :|:|.:|:.:|     |.|.|.|.||||  :.:.|:||       
Zfish   442 GGADDGADRENFDPDTGSGMLFLSNVTVAHA-----GRYECEAWNPGGVARVTFHLSVNMSSSSS 501

  Fly   389 --------------------VVQKDMERISLIDSNFF--AIVCLIAMGFLSMSILFSLVTCLIFK 431
                                |.|:.:..:..:|.|..  |....||:|...:::...|:.|:|:.
Zfish   502 RSEIWPRLHSSSYYHPSSVDVSQEPLYELESMDFNALGTATQTAIAVGISLLALTALLLLCMIYS 566

  Fly   432 RFKQ 435
            |.:|
Zfish   567 RHRQ 570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_001260435.1 leucine-rich repeat 75..99 CDD:275380 5/23 (22%)
LRR_8 99..158 CDD:290566 18/58 (31%)
leucine-rich repeat 100..123 CDD:275380 6/22 (27%)
leucine-rich repeat 124..147 CDD:275380 8/22 (36%)
LRR_8 146..206 CDD:290566 18/59 (31%)
leucine-rich repeat 148..171 CDD:275380 8/22 (36%)
leucine-rich repeat 172..195 CDD:275380 7/22 (32%)
leucine-rich repeat 196..219 CDD:275380 7/22 (32%)
TPKR_C2 228..277 CDD:301599 15/60 (25%)
IG_like 294..390 CDD:214653 26/160 (16%)
Ig 296..387 CDD:143165 23/128 (18%)
lrrc24XP_009297158.1 leucine-rich repeat 151..174 CDD:275378 5/24 (21%)
LRR_8 174..257 CDD:290566 25/82 (30%)
LRR_4 174..238 CDD:289563 19/63 (30%)
leucine-rich repeat 175..222 CDD:275378 14/46 (30%)
leucine-rich repeat 199..218 CDD:275380 6/18 (33%)
LRR_8 222..304 CDD:290566 24/81 (30%)
LRR_4 222..258 CDD:289563 11/35 (31%)
leucine-rich repeat 223..246 CDD:275378 8/22 (36%)
leucine-rich repeat 247..294 CDD:275378 14/46 (30%)
leucine-rich repeat 295..307 CDD:275378 5/11 (45%)
LRRCT 303..356 CDD:214507 15/59 (25%)
IG_like 365..494 CDD:214653 26/140 (19%)
Ig 376..491 CDD:143165 22/126 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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