DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and lingo1a

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_005174327.1	Gene:	lingo1a / 564943	ZFINID:	ZDB-GENE-080327-16	Length:	615	Species:	Danio rerio

Alignment Length:	573	Identity:	125/573 - (21%)
Similarity:	187/573 - (32%)	Gaps:	217/573 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 CKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHI----------------FYLEEN----- 90
            |:.|..:::..|....|..|||.:..|.::||||.|.|                ..|.||
Zfish    39 CECNVQERSVLCHRKKLMSVPEGIPSETRLLDLSKNRIKTINPDEFSAFPQLEELELNENTISAI 103

  Fly    91 ---AFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIF 152
               ||  .:|..||.|.:|:..||.:....||.|..|.:||:|.|.:|.||..:|..|..:|::.
Zfish   104 EPGAF--NNLYGLQTLGLRSNKLKLIQLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLRSLE 166

  Fly   153 LNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDL 217
            :..|.|..:.|..|..|..|.::.|::..|.|:..:||..:..|..:.|.|..:..:|..||:.|
Zfish   167 VGDNDLVFISHRAFHGLSSLEQLTLEKCNLTSVPTEAFTHLHSLVTLRLRNLNINSIRDYSFKRL 231

  Fly   218 TKLTALSLVENPW------NCTCDLQMFRDFVIGMNLYTPP-------------TSCHYPLQL-- 261
            .:|..|.:...|:      ||...|.:....:...||.:.|             ...:.|:|:
Zfish   232 YRLKVLEIANWPYLDTMTTNCLYGLNLTSLTITNANLTSIPYLALRHLVYLRFLNMSYNPIQMIE 296

  Fly   262 ----------------------------RG-----------------------------RLWIED 269
                                        ||                             .|.:.|
Zfish   297 GNRLHDLLRLQELYLVGGRLSVIEPYSFRGLNYLKVLNVSSNFLTTLEESVFHSVGNLETLALHD 361

  Fly   270 QPEAFACK----------------------------------PKIVYPTLST----SINTSK--- 293
            .|.|..|:                                  |.|:.|...|    .|...|
Zfish   362 NPLACDCRLLWVFRRRWRLNFNRQQPTCSSPEFVQGKEFKDFPDILQPNYFTCRKSRIRDRKPQQ 426

  Fly   294 ----ENVTL--ICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHD 352
                |..|:  :|:..|.|..||.|              .|.|||.|.::.
Zfish   427 KFVDEGTTVHFVCQADGDPTPVIMW--------------LSPQKQFITMKT-------------- 463

  Fly   353 VFVSRLTIV--------NARKSDEGVYTCLAENPGGKDS--VHISV----------------VVQ 391
              :.|||:.        .|:..|.|.|.|:|.|.||.|:  .|:.|                .:.
Zfish   464 --IGRLTVFPDGTLEVRYAQIQDNGTYGCIASNAGGNDTALAHLHVHSYSPDWPNQPNKTLAFIS 526

  Fly   392 KDMERISLIDSNF-----FAIVCLI---AMGFLSM--SILFSLVTCLIFKRFK 434
            ......|:.::..     |.|..||   .|||:|.  .:||.||...::.|.|
Zfish   527 NQPNDNSINETRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGK 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	12/47 (26%)
		LRR_8	99..158	CDD:290566	21/58 (36%)
		leucine-rich repeat	100..123	CDD:275380	9/22 (41%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		LRR_8	146..206	CDD:290566	15/59 (25%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	7/22 (32%)
		TPKR_C2	228..277	CDD:301599	15/126 (12%)
		IG_like	294..390	CDD:214653	28/123 (23%)
		Ig	296..387	CDD:143165	26/102 (25%)
lingo1a	XP_005174327.1	LRRNT	34..68	CDD:214470	8/28 (29%)
		LRR_RI	<55..231	CDD:238064	54/177 (31%)
		leucine-rich repeat	66..89	CDD:275380	6/22 (27%)
		LRR_8	88..148	CDD:290566	20/61 (33%)
		leucine-rich repeat	90..113	CDD:275380	6/24 (25%)
		leucine-rich repeat	114..137	CDD:275380	9/22 (41%)
		LRR_8	136..196	CDD:290566	18/59 (31%)
		leucine-rich repeat	138..185	CDD:275380	16/46 (35%)
		LRR_8	184..241	CDD:290566	15/56 (27%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..257	CDD:275380	12/46 (26%)
		leucine-rich repeat	234..256	CDD:275380	5/21 (24%)
		LRR_8	257..316	CDD:290566	5/58 (9%)
		leucine-rich repeat	258..281	CDD:275380	3/22 (14%)
		leucine-rich repeat	282..305	CDD:275380	2/22 (9%)
		LRR_8	305..364	CDD:290566	4/58 (7%)
		leucine-rich repeat	306..329	CDD:275380	2/22 (9%)
		leucine-rich repeat	330..350	CDD:275380	0/19 (0%)
		TPKR_C2	362..>398	CDD:301599	3/35 (9%)
		I-set	421..507	CDD:254352	28/115 (24%)
		Ig	432..507	CDD:299845	26/104 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12360
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910