DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and lingo2b

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001139054.1	Gene:	lingo2b / 564052	ZFINID:	ZDB-GENE-080723-57	Length:	607	Species:	Danio rerio

Alignment Length:	642	Identity:	119/642 - (18%)
Similarity:	182/642 - (28%)	Gaps:	286/642 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CSISLKHLSLFLFKIYCLALIFRSASADWLLDCGNCHCKWNSGKKTADCRNLSLSGVPEYLSPEV 74
            |::.|..|.|.||:....|...|            |.|  :...::..|....|:.|||.:..|.
Zfish     8 CALGLSLLPLHLFQCPAHACPAR------------CEC--SVPTRSVSCHRRRLAQVPEGIPIET 58

  Fly    75 QVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLP 139
            :.||||.|.                          |:.:..::|:.|.:|.|||||||||..:.|
Zfish    59 RSLDLSKNR--------------------------LRIVTPQNFSSLLLLEELDLSNNLLSSVEP 97

  Fly   140 NVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHKIELKRNRLV--------------------- 183
            |.|....::|::.|..|.|..|..|....|..|..:::.:||||
Zfish    98 NSFRAQPRLRSLRLRSNQLTLLPRGALAGLSELTLLDVSQNRLVILLDYGFEEQRRLRVLELSDN 162

  Fly   184 ---------------------------------------------------SIDAKAFVGVPLLS 197
                                                               .:.|..|.|:|.|.
Zfish   163 ELVFIAPRAFSGLASLRSLTLQRCNLSTVPTHALAHLHGLTSLRLRDLGIAELQAHTFKGLPRLK 227

  Fly   198 QIYLD-------------------------------------------NNELTKLRV-------- 211
            .:.:|                                           |...:::||
Zfish   228 HLEVDRWPLLEGFPTSALQGLNLSTLSITHTNLTSVPVVTNLLYLTHLNLSYSRIRVLPAGWLRG 292

  Fly   212 -------------------ESFQDLTKLTALSLV------------------------ENPWNCT 233
                               ::||..:.|..|.|.                        :||..|.
Zfish   293 MDRLEVLRVRQANLLSVEPQAFQGASSLRILDLCYNRLATLERSVFPVTEALQTLLIGQNPLVCD 357

  Fly   234 CDLQMFRDFVIGMNLYTPP-------TSCHYPLQLRGRLWIEDQPEA------FACKPKIV---- 281
            |.|:...:       .|||       ..|..|..|.|:. :.|..||      ...||:::
Zfish   358 CRLRWLLE-------RTPPLLYGDVQPECSAPAPLAGKP-LRDLVEAQISRYVICTKPRVISMAS 414

  Fly   282 YPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKI 346
            ||..:    ...:...|.|...|:|...::|                |...|.:|.........:
Zfish   415 YPAQA----EEGQRAWLYCSADGAPPPSVSW----------------LTPLRRHITTKSTGRVVV 459

  Fly   347 RKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQKDMER--------------- 396
            ...|      .|....|...|.|:|.|:|.||.|..::.:::.|:....|
Zfish   460 HTNG------SLEFRMAEPQDSGMYVCVASNPAGNATLSVTLAVKTSGIRDRALYANRSFLFDPD 518

  Fly   397 --ISLIDS----------NFFAIVCLIAMGFLSM--SILFSLVTCLIFKRFKQFHPG 439
              .|||:.          :|..|:...|||.||.  .:||..:....:.|.|..|.|
Zfish   519 YNSSLINGTEEYTIRVVLDFTTILVSTAMGCLSFLGVVLFCFLLLFAWSRGKGKHRG 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	5/23 (22%)
		LRR_8	99..158	CDD:290566	19/58 (33%)
		leucine-rich repeat	100..123	CDD:275380	3/22 (14%)
		leucine-rich repeat	124..147	CDD:275380	13/22 (59%)
		LRR_8	146..206	CDD:290566	19/174 (11%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..195	CDD:275380	8/94 (9%)
		leucine-rich repeat	196..219	CDD:275380	7/92 (8%)
		TPKR_C2	228..277	CDD:301599	15/61 (25%)
		IG_like	294..390	CDD:214653	19/95 (20%)
		Ig	296..387	CDD:143165	19/90 (21%)
lingo2b	NP_001139054.1	LRRNT	26..58	CDD:214470	9/45 (20%)
		leucine-rich repeat	37..60	CDD:275380	6/22 (27%)
		LRR_8	59..116	CDD:290566	24/82 (29%)
		leucine-rich repeat	61..81	CDD:275380	8/45 (18%)
		LRR_RI	<103..214	CDD:238064	12/110 (11%)
		LRR_8	104..188	CDD:290566	12/83 (14%)
		leucine-rich repeat	106..129	CDD:275380	7/22 (32%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..177	CDD:275380	0/22 (0%)
		leucine-rich repeat	178..201	CDD:275380	0/22 (0%)
		LRR_8	201..260	CDD:290566	6/58 (10%)
		leucine-rich repeat	202..225	CDD:275380	3/22 (14%)
		leucine-rich repeat	226..271	CDD:275380	2/44 (5%)
		LRR_8	272..330	CDD:290566	8/57 (14%)
		leucine-rich repeat	272..295	CDD:275380	3/22 (14%)
		leucine-rich repeat	296..319	CDD:275380	2/22 (9%)
		leucine-rich repeat	320..338	CDD:275380	3/17 (18%)
		leucine-rich repeat	344..356	CDD:275378	2/11 (18%)
		LRRCT	352..394	CDD:214507	13/49 (27%)
		IG_like	419..497	CDD:214653	19/103 (18%)
		Ig	422..497	CDD:299845	19/96 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12360
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910