DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and lingo4b

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001082850.1	Gene:	lingo4b / 559074	ZFINID:	ZDB-GENE-091214-3	Length:	604	Species:	Danio rerio

Alignment Length:	600	Identity:	123/600 - (20%)
Similarity:	194/600 - (32%)	Gaps:	221/600 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IYCLALIFRSASADWLLDCGNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLE 88
            ::||.|    ::||  |.|.. .|..:......:|.:..|:.|||.|....:.||||.|.:..|.
Zfish    17 LWCLNL----SAAD--LPCPQ-RCSCSRDPLEVNCSSRHLTAVPEGLPTNAKRLDLSGNQLKTLA 74

  Fly    89 ENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFL 153
            ...|  :.|..|:.|.:....:..:...:|..|:.|..|.:.||.|..|...||..||.:|.:.:
Zfish    75 RRQF--SSLSKLEDLDLSENIISMIEVETFQGLKNLRYLRIKNNRLKILPVGVFSGLSNLRRLDI 137

  Fly   154 NGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLT 218
            :.|.:.......||::..|.:::...|.||.|..:||||:..|.::.:|.:.||.:..|:...|.
Zfish   138 SENEILVFLDYTFRDMINLQQLDAGENDLVFISQRAFVGLQALKELNVDRSNLTSIPTEALSQLQ 202

  Fly   219 KLTAL-------SLVEN---------------PWNCTCDLQMFR-DFVIGMNL------------ 248
            .||.|       |::.|               .|:   .|:|.. :.::|:||
Zfish   203 SLTKLRLRKLTISVLPNNAFRRLHQLRTLQILHWS---SLEMLNSNSLVGLNLTTLVLTNCNLSA 264

  Fly   249 ------------------YTPPTSCH----------YPLQLRGRLWIEDQPEAF----------- 274
                              |.|.||..          ..|.|.|...:..:|.||
Zfish   265 IPYSPLRHLAYLQYLDLSYNPITSIQGNLLGDLLRLQELHLVGGNLLRIEPGAFRGLSRFRLLNV 329

  Fly   275 -----------------------------ACKPKIVY--------------PTLS---------- 286
                                         ||..::::              ||.|
Zfish   330 SSNRLSTLEESAFHSVGNLQTLRLDRNPLACDCRLLWVMRRRRRLDFDGRQPTCSPLNHQRKAFR 394

  Fly   287 ----------------TSINTSKENVTLI--------CRVHGSPNTVIAWDYTNQVYESRSKPVK 327
                            ..:|...:::::|        |:..|.|:..|.|....|...|.:..|:
Zfish   395 DFSEAELPVVFTCRQAQILNRQLQDISVIEGMRVHFDCKADGYPSPSITWLSAQQSALSSAGRVR 459

  Fly   328 SLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQ- 391
            .|..                        ..|.|..|:..|.|.|.|.|.|..|.||:.:|:.|:
Zfish   460 VLTN------------------------GSLQISYAQVQDSGTYLCSAANAAGNDSISVSLHVEG 500

  Fly   392 ------------------------KDMERISL---IDSNFFAIVCLIAMGFLSMSILFSLVTCLI 429
                                    ....|:|.   .|:.  .::....||||  |.|.|:..|.:
Zfish   501 LPQNRTVSYFSDEGWIETSAPPSTNSSARVSSPYPFDAK--TLIIATTMGFL--SFLSSVAICFV 561

  Fly   430 FKRFKQFHPGQ--HT 442
            |..|.....||  ||
Zfish   562 FMFFWSQSKGQIKHT 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	8/23 (35%)
		LRR_8	99..158	CDD:290566	16/58 (28%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		LRR_8	146..206	CDD:290566	16/59 (27%)
		leucine-rich repeat	148..171	CDD:275380	4/22 (18%)
		leucine-rich repeat	172..195	CDD:275380	9/22 (41%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	18/144 (13%)
		IG_like	294..390	CDD:214653	23/103 (22%)
		Ig	296..387	CDD:143165	22/98 (22%)
lingo4b	NP_001082850.1	LRRNT	28..61	CDD:214470	8/33 (24%)
		leucine-rich repeat	41..62	CDD:275380	6/20 (30%)
		LRR	<56..304	CDD:227223	57/252 (23%)
		leucine-rich repeat	63..83	CDD:275380	8/21 (38%)
		leucine-rich repeat	84..107	CDD:275380	4/22 (18%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		leucine-rich repeat	132..155	CDD:275380	4/22 (18%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..203	CDD:275380	6/22 (27%)
		leucine-rich repeat	204..251	CDD:275380	9/49 (18%)
		leucine-rich repeat	228..250	CDD:275380	3/24 (13%)
		leucine-rich repeat	252..275	CDD:275380	1/22 (5%)
		leucine-rich repeat	276..297	CDD:275380	4/20 (20%)
		LRR_8	299..358	CDD:316378	6/58 (10%)
		leucine-rich repeat	300..321	CDD:275380	6/20 (30%)
		leucine-rich repeat	324..344	CDD:275380	0/19 (0%)
		I-set	415..498	CDD:254352	23/106 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000