DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and LRRN3

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001093128.1	Gene:	LRRN3 / 54674	HGNCID:	17200	Length:	708	Species:	Homo sapiens

Alignment Length:	753	Identity:	152/753 - (20%)
Similarity:	237/753 - (31%)	Gaps:	268/753 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LKHLSLFLFKIYCLALIFRSASADWLLDCGN-CHCK---WNSGK------KTADCRNLSLSGVPE 68
            :|.:.|.:..:..||:.....:.|..:||.. |.|:   |.:.:      .|.||.:|.|...|.
Human     1 MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPA 65

  Fly    69 YLSPEVQV-----------------------LDLSHNHI----------------FYLEENAFLT 94
            .|....|:                       ||||.|::                .|||||. ||
Human    66 RLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENK-LT 129

  Fly    95 -------THLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLL-------VDLLPNV---- 141
                   :.|.|||:|.|.:..|..::..:|..|..|:.|.|::|.|       .|.|||:
Human   130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILM 194

  Fly   142 -------------FDCLSKVRAIF----------------------------------------- 152
                         |..|..:|::.
Human   195 IGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKV 259

  Fly   153 -------LNGNLLQALRHGVFRNLKY-------------------------LHKIELKRN-RLVS 184
                   ||.|.:..:|.|.|.|:.:                         |.|||...| ||..
Human   260 VNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSY 324

  Fly   185 IDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVENPWNCTCDLQMFRDFVIGMNL- 248
            |...||..:|.|..:.|::|.|:.|...:.:.|..|..:|:..||..|.|.::.       ||:
Human   325 IHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRW-------MNMN 382

  Fly   249 -----YTPPTS--CHYPLQLRG----RLWIEDQPEAFACKPKIVYPTLSTSINTSKEN-VTLICR 301
                 :..|.|  |..|.:.:|    ::...|..|  .|.|.|...:..:::|....: |:..||
Human   383 KTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMME--ICLPLIAPESFPSNLNVEAGSYVSFHCR 445

  Fly   302 VHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKS 366
            ....|...|.|     :..|..|.:.:....:.|:              |.  ...|.|......
Human   446 ATAEPQPEIYW-----ITPSGQKLLPNTLTDKFYV--------------HS--EGTLDINGVTPK 489

  Fly   367 DEGVYTCLAENPGGKDSVHISVVVQKDME---------RISLIDSNFFAIVCLIAMGFLSMSILF 422
            :.|:|||:|.|..|.|...:.:.|.....         :|..|.:|     .::.....|..||.
Human   490 EGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQAN-----SVLVSWKASSKILK 549

  Fly   423 SLVTCLIFKRFKQFHPGQHTYLQPTSLPVQ-----SPGSEEATAISALSSGVIRESKIVLDPLSA 482
            |.|....|.:.:..|..|...: |:.:.|.     :|.:|....|...:.......|.|......
Human   550 SSVKWTAFVKTENSHAAQSARI-PSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTKG 613

  Fly   483 INEPSNKNYTLFKTS--------------------------NSNGSEYMHTRNYKDVRLNSNTYT 521
            :: |..|.|....|:                          |.:|. :.:.|||    |...|:.
Human   614 LH-PDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGG-HSYVRNY----LQKPTFA 672

  Fly   522 ENLDNQAESISSRNRELYSNI-----AGDREKEELKQK 554
            ..             |||..:     ||..:...||.|
Human   673 LG-------------ELYPPLINLWEAGKEKSTSLKVK 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	14/69 (20%)
		LRR_8	99..158	CDD:290566	23/130 (18%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..147	CDD:275380	11/46 (24%)
		LRR_8	146..206	CDD:290566	22/133 (17%)
		leucine-rich repeat	148..171	CDD:275380	8/70 (11%)
		leucine-rich repeat	172..195	CDD:275380	10/23 (43%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	13/60 (22%)
		IG_like	294..390	CDD:214653	20/96 (21%)
		Ig	296..387	CDD:143165	20/90 (22%)
LRRN3	NP_001093128.1	LRRNT	28..72	CDD:214470	12/43 (28%)
		LRR 1	70..91		1/20 (5%)
		leucine-rich repeat	72..93	CDD:275380	1/20 (5%)
		LRR	<75..355	CDD:227223	56/280 (20%)
		LRR 2	93..114		5/20 (25%)
		leucine-rich repeat	94..117	CDD:275380	5/22 (23%)
		LRR 3	117..138		7/21 (33%)
		leucine-rich repeat	118..141	CDD:275380	8/23 (35%)
		LRR 4	141..162		7/20 (35%)
		leucine-rich repeat	142..165	CDD:275380	7/22 (32%)
		LRR 5	165..186		5/20 (25%)
		leucine-rich repeat	166..189	CDD:275380	7/22 (32%)
		LRR 6	189..210		2/20 (10%)
		leucine-rich repeat	190..213	CDD:275380	2/22 (9%)
		LRR 7	213..234		1/20 (5%)
		leucine-rich repeat	214..237	CDD:275380	1/22 (5%)
		LRR 8	237..258		0/20 (0%)
		leucine-rich repeat	238..261	CDD:275380	0/22 (0%)
		LRR 9	261..282		6/20 (30%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		LRR 10	285..304		0/18 (0%)
		leucine-rich repeat	286..310	CDD:275380	0/23 (0%)
		LRR 11	310..332		10/21 (48%)
		leucine-rich repeat	311..333	CDD:275380	10/21 (48%)
		LRR 12	335..358		5/22 (23%)
		leucine-rich repeat	336..359	CDD:275380	6/22 (27%)
		PCC	341..>442	CDD:188093	25/109 (23%)
		Ig	437..513	CDD:325142	20/96 (21%)
		fn3	526..593	CDD:306538	15/72 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910