DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and Lrrn1

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001032440.1	Gene:	Lrrn1 / 500280	RGDID:	1564145	Length:	716	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	111/518 - (21%)
Similarity:	177/518 - (34%)	Gaps:	184/518 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LALIFRSASADWLL--DCGN-CHCK---WNSGKK------TADCRNLSLSGVPEYLSPEVQVLDL 79
            |.|:..|.:...:|  :|.. |.|:   |.:.:.      |.||.:|.|:.:|..||.:.|||.|
  Rat    15 LGLLIPSLTESSILNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPGNLSSDTQVLLL 79

  Fly    80 SHNHI---------------------------------------FYLEENA------FLTTHLQN 99
            ..|:|                                       .:||||.      :....|.|
  Rat    80 QSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQISEMTDYCLQDLSN 144

  Fly   100 LQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLL-------VDLLPNV---------------- 141
            ||:|.|.:..:..::..:|:.|:.|:.|.|::|.|       .|..||:
  Rat   145 LQELYINHNQISSISANAFSGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDM 209

  Fly   142 -FDCLSKVRAIF------------------------------------------------LNGNL 157
             |..||.:|::.                                                ||.|.
  Rat   210 NFRPLSNLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLIKVPQLALQKVPNLKFLDLNKNP 274

  Fly   158 LQALRHGVFRNLKYLHKIELKR-NRLVSID-------------------------AKAFVGVPLL 196
            :..::.|.|:|:..|.::.:.. ..|||:|                         ..||..||.|
  Rat   275 IHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPAL 339

  Fly   197 SQIYLDNNELTKLRVESFQDLTKLTALSLVENPWNCTCDLQMFRDFVIGMNLYTPPTS-CHYPLQ 260
            ..:.|:||.|..:..::.:.|..|..:|:..||..|.|.:.........:....|.:. |..|.:
  Rat   340 ESLMLNNNALNAVYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPE 404

  Fly   261 LRGR----LWIEDQPEAFACKPKIVYPTLSTSINTS-KENVTLICRVHGSPNTVIAWDYTNQVYE 320
            .||:    :.|:|..|  .|.|.|.:.|....:|.. ...:.|.||....|...|.|
  Rat   405 YRGQQVKEVLIQDSSE--QCLPMISHDTFPNHLNMDIGTTLFLDCRAMAEPEPEIYW-------- 459

  Fly   321 SRSKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDS 383
              ..|:.:    :|.:|.| .|:.|:...|      .|.|.|.:..|.|.|||:|:|..|.|:
  Rat   460 --VTPIGN----KITVETL-SDKYKLSSEG------TLEIANIQIEDSGRYTCVAQNVQGADT 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	11/68 (16%)
		LRR_8	99..158	CDD:290566	22/130 (17%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		leucine-rich repeat	124..147	CDD:275380	10/46 (22%)
		LRR_8	146..206	CDD:290566	21/133 (16%)
		leucine-rich repeat	148..171	CDD:275380	7/70 (10%)
		leucine-rich repeat	172..195	CDD:275380	8/48 (17%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	12/53 (23%)
		IG_like	294..390	CDD:214653	25/90 (28%)
		Ig	296..387	CDD:143165	25/88 (28%)
Lrrn1	NP_001032440.1	leucine-rich repeat	54..73	CDD:275380	8/18 (44%)
		LRR	<68..372	CDD:227223	55/303 (18%)
		LRR 1	73..95		6/21 (29%)
		leucine-rich repeat	74..96	CDD:275380	6/21 (29%)
		LRR 2	96..117		0/20 (0%)
		leucine-rich repeat	97..120	CDD:275380	0/22 (0%)
		LRR 3	120..141		4/20 (20%)
		leucine-rich repeat	121..144	CDD:275380	5/22 (23%)
		LRR 4	144..165		6/20 (30%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		LRR 5	168..189		5/20 (25%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		LRR 6	192..213		2/20 (10%)
		leucine-rich repeat	193..216	CDD:275380	2/22 (9%)
		LRR 7	216..237		1/20 (5%)
		leucine-rich repeat	217..240	CDD:275380	1/22 (5%)
		LRR 8	240..261		0/20 (0%)
		leucine-rich repeat	241..264	CDD:275380	0/22 (0%)
		LRR 9	264..285		5/20 (25%)
		leucine-rich repeat	265..288	CDD:275380	6/22 (27%)
		leucine-rich repeat	289..313	CDD:275380	5/23 (22%)
		leucine-rich repeat	314..335	CDD:275380	2/20 (10%)
		leucine-rich repeat	339..362	CDD:275378	6/22 (27%)
		leucine-rich repeat	363..375	CDD:275378	4/11 (36%)
		LRRCT	371..419	CDD:214507	11/47 (23%)
		I-set	429..516	CDD:400151	27/102 (26%)
		Ig strand A'	433..438	CDD:409353	1/4 (25%)
		Ig strand B	441..450	CDD:409353	3/8 (38%)
		Ig strand C	456..460	CDD:409353	2/13 (15%)
		Ig strand C'	463..465	CDD:409353	0/1 (0%)
		Ig strand D	478..481	CDD:409353	0/2 (0%)
		Ig strand E	482..487	CDD:409353	2/10 (20%)
		Ig strand F	495..503	CDD:409353	5/7 (71%)
		Ig strand G	506..516	CDD:409353	2/4 (50%)
		FN3	531..600	CDD:214495
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..716
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9069
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910