Protein Alignment kek4 and Lingo4

DIOPT Version :10

• Sequence 1: NP_609615.2
• Gene: kek4 / 34718
• FlyBaseID: FBgn0032484
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001102659.1
• Gene: Lingo4 / 499668
• RGDID: 1562025
• Length: 618
• Species: Rattus norvegicus
• Alignment Length: 595
• Identity: 113/595 - (18%)
• Similarity: 178/595 - (29%)
• Gaps: 200/595 - (33%)

  Fly    34 ASADWLLDCGNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQ 98
            :|...|.||       .|..:...|.:..|..||..|..:.:|||||.|.::.|:..  :.:.|.
  Rat    54 SSCPTLCDC-------TSQTRAVLCAHRRLDTVPGGLPLDTEVLDLSGNRLWGLQRG--MLSRLG 109

  Fly    99 NLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRH 163
            .||:|.:....|..|...:|..||.|:.|.|..|.|..:.|.:|..||.:..:.|..|.:.....
  Rat   110 QLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIVGPGIFSGLSALTLLDLRLNQIVLFLD 174

  Fly   164 GVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNE----------------------- 205
            |.|..|..|.::|:..|.||.:...||.|:..||.|.|:...
  Rat   175 GAFGELGSLQQLEVGDNHLVFVAPGAFSGLAKLSTITLERCNLSTVPGLALAQLPALVALRLREL 239

  Fly   206 ----------------------------------------------------------------- 205
                                                                             
  Rat   240 DIERLPSGALRGLGQLKELEIHHWPSLEALDPGSLVGLNLSSLAITHCNLSSVPFQALHHLSFLQ 304

  Fly   206 --------------------------------LTKLRVESFQDLT-------------------- 218
                                            ||.:...:|..||
  Rat   305 VLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAF 369

  Fly   219 ----KLTALSLVENPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIEDQ----PEAFA 275
                ||..|.|..||..|.|.|.........::..|.|.:|..|..::|:...|..    |..|.
  Rat   370 PSPDKLVTLRLSGNPLTCDCRLLWLLRLRRRLDFGTSPPACAGPQHVQGKNLREFSDILPPGHFT 434

  Fly   276 CKPKIVYPTLSTSINTSK-ENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELL 339
            |||.::..:....:...: .:....|...|.|...::|......:..|...|:.|
  Rat   435 CKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPQGSWLGRVGRVRVL---------- 489

  Fly   340 REDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISV-VVQKDMERISLIDSN 403
             ||             ..|.|.:.:..|.|.|.|:..|..|.||:...: |:|.:....:|.|.|
  Rat   490 -ED-------------GTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPN 540

  Fly   404 FF-------------AIVCLIAMGFL----SMSILFSLVTCLIFKRFKQFHPGQHTYLQPTSLPV 451
            ..             .:..::|:|||    |:::.|.|:......:.:..|.....::.|.....
  Rat   541 VTMPGIPGPFSLDSRGVAMVLAVGFLPFLTSVTLCFGLIALWSKGKGRVKHHMTFDFVAPRPSGD 605

  Fly   452 QSPGSEEATA 461
            ::.|....||
  Rat   606 KNSGGNRVTA 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_609615.2	LRR	59..>228	CDD:443914	55/312 (18%)
		leucine-rich repeat	75..99	CDD:275380	8/23 (35%)
		LRR_8	98..158	CDD:404697	19/59 (32%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..195	CDD:275380	8/22 (36%)
		leucine-rich repeat	196..219	CDD:275380	9/166 (5%)
		LRRCT	228..277	CDD:214507	13/52 (25%)
		IG_like	294..390	CDD:214653	19/96 (20%)
		Ig strand B	296..300	CDD:409353	0/3 (0%)
		Ig strand C	309..323	CDD:409353	1/13 (8%)
		Ig strand E	356..360	CDD:409353	1/3 (33%)
		Ig strand F	370..375	CDD:409353	2/4 (50%)
		Ig strand G	383..386	CDD:409353	1/2 (50%)
Lingo4	NP_001102659.1	leucine-rich repeat	87..110	CDD:275380	8/24 (33%)
		LRR	<88..441	CDD:443914	67/354 (19%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		leucine-rich repeat	159..182	CDD:275380	5/22 (23%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		leucine-rich repeat	207..230	CDD:275380	4/22 (18%)
		leucine-rich repeat	231..254	CDD:275380	0/22 (0%)
		leucine-rich repeat	255..302	CDD:275380	0/46 (0%)
		leucine-rich repeat	303..326	CDD:275380	0/22 (0%)
		leucine-rich repeat	327..348	CDD:275380	3/20 (15%)
		leucine-rich repeat	351..374	CDD:275380	0/22 (0%)
		IG_like	445..526	CDD:214653	19/104 (18%)
		Ig strand B	456..460	CDD:409353	0/3 (0%)
		Ig strand C	469..473	CDD:409353	0/3 (0%)
		Ig strand E	492..496	CDD:409353	1/3 (33%)
		Ig strand F	506..511	CDD:409353	2/4 (50%)
		Ig strand G	519..522	CDD:409353	1/2 (50%)