DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and lrfn1

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_956909.1	Gene:	lrfn1 / 393587	ZFINID:	ZDB-GENE-040426-1227	Length:	584	Species:	Danio rerio

Alignment Length:	435	Identity:	95/435 - (21%)
Similarity:	157/435 - (36%)	Gaps:	131/435 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IYCLALIFRSASADWLLDCGNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLE 88
            ::|: |:| .|.|...|..|.|.|:..|...|..|....|..||..:..:...|.|:.|
Zfish     5 VFCV-LVF-GALAKAQLCPGRCICQTISPTLTLLCAKTGLLFVPPTVDRKTVELRLTDN------ 61

  Fly    89 ENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFL 153
               |:|.                 :.::.|..:..|:.|.||.|.:..:.|:.|..|..:||:.:
Zfish    62 ---FITA-----------------VRRKDFLNMTSLVHLTLSRNTISQIAPHAFMGLKSLRALHM 106

  Fly   154 NGNLLQA-----------LRHGVFRNLKYLHKIE---------------LKRNRLVSIDAKAFVG 192
            :||.|..           |||.:..| ..:|.||               |..|.|.::..:|...
Zfish   107 DGNRLSVINSDQLKGLMNLRHLILGN-NQIHHIEESSFDEFVATIEDLDLSYNNLRTLPWEAIAR 170

  Fly   193 VPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVE------------------------------ 227
            :..::.:.||:|.:..:.|.:|..||||..|.:..
Zfish   171 MTNINTLTLDHNLIDHIGVGTFTLLTKLVRLDMTSNRLQTLPPDTLFQHAQVLSEPKTSSSSRLT 235

  Fly   228 -----NPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIEDQPEAFACKPKIVYPTLST 287
                 ||.:|.|:|...|......:|.|    |..|..|..:.:...|.|.|.|:|.::     |
Zfish   236 VSFGGNPLHCNCELLWLRRLTREDDLET----CASPEHLMDKYFWSIQEEEFICEPPLI-----T 291

  Fly   288 SINTSK------ENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKI 346
            ....:|      :.|||.|:..|.|:..|.|.:.:      .|.|.:..:..:|      |...:
Zfish   292 KHQVTKPYVMEGQGVTLKCKAMGDPDPAIHWRFPD------GKLVHNNSRTILY------DNGTL 344

  Fly   347 RKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGG--KDSVHISVV 389
                 |:.::.|       .|.|.:.|:|.|..|  ..:||:.::
Zfish   345 -----DILITTL-------KDSGAFNCVASNAAGIATAAVHVHMI 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	5/23 (22%)
		LRR_8	99..158	CDD:290566	13/58 (22%)
		leucine-rich repeat	100..123	CDD:275380	1/22 (5%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR_8	146..206	CDD:290566	19/85 (22%)
		leucine-rich repeat	148..171	CDD:275380	9/33 (27%)
		leucine-rich repeat	172..195	CDD:275380	7/37 (19%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	14/48 (29%)
		IG_like	294..390	CDD:214653	22/98 (22%)
		Ig	296..387	CDD:143165	22/92 (24%)
lrfn1	NP_956909.1	LRR 1	52..73		6/46 (13%)
		LRR_8	55..111	CDD:290566	18/81 (22%)
		leucine-rich repeat	55..76	CDD:275380	6/46 (13%)
		LRR_RI	<71..>208	CDD:238064	35/137 (26%)
		LRR 2	76..97		7/20 (35%)
		leucine-rich repeat	77..100	CDD:275380	8/22 (36%)
		LRR_8	99..160	CDD:290566	14/61 (23%)
		LRR 3	100..121		5/20 (25%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR 4	124..145		7/21 (33%)
		leucine-rich repeat	125..148	CDD:275380	7/23 (30%)
		LRR 5	149..170		4/20 (20%)
		leucine-rich repeat	150..173	CDD:275380	4/22 (18%)
		LRR_8	153..208	CDD:290566	14/54 (26%)
		LRR 6	173..194		5/20 (25%)
		leucine-rich repeat	174..197	CDD:275380	6/22 (27%)
		LRR 7	197..218		3/20 (15%)
		leucine-rich repeat	198..222	CDD:275380	2/23 (9%)
		LRRCT	241..>270	CDD:214507	10/32 (31%)
		IG_like	299..375	CDD:214653	22/99 (22%)
		Ig_2	303..376	CDD:143241	22/96 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..414
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910