Protein Alignment kek4 and ISLR

DIOPT Version :10

• Sequence 1: NP_609615.2
• Gene: kek4 / 34718
• FlyBaseID: FBgn0032484
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_005536.1
• Gene: ISLR / 3671
• HGNCID: 6133
• Length: 428
• Species: Homo sapiens
• Alignment Length: 371
• Identity: 90/371 - (24%)
• Similarity: 140/371 - (37%)
• Gaps: 74/371 - (19%)

  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109
            |.|....|.:.|||....|..||......|..|.||.|.:..|.|.||....|  ||.|.:.:..
Human    23 CDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPL--LQSLWLAHNE 85

  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHK 174
            ::.:...:...|..|..||||:||:.|...:....||.::.:.::.|.|..:....||:|:.|..
Human    86 IRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRS 150

  Fly   175 IELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVENPWNCTCDLQMF 239
            ::|..|||.:                        |...:|..||.|:.|.:.|||::|||.:...
Human   151 LQLNHNRLHT------------------------LAEGTFTPLTALSHLQINENPFDCTCGIVWL 191

  Fly   240 RDFVIGMNLYTPP---TSCHYPLQLRGRLWIEDQPEAFACKPKIVYPTLSTSINTSKEN------ 295
            :.:.:...:..|.   .:|..|..|:|.......|  ..|..    |::..|...|::.
Human   192 KTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPP--LPCSA----PSVQLSYQPSQDGAELRPG 250

  Fly   296 --VTLICRVHGSPNTVIAW--DYTNQVYESRS------------KPVKSLQKQRIYIELLREDES 344
              :.|.|.|.|.|...:.|  ...:.:.|..|            .||.|.|             .
Human   251 FVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASSQ-------------P 302

  Fly   345 KIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVV 390
            :.:.|.:    ..|.|.:..|.:||.|:|||.|..|.....:.|.:
Human   303 RFQAFAN----GSLLIPDFGKLEEGTYSCLATNELGSAESSVDVAL 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_609615.2	LRR	59..>228	CDD:443914	43/168 (26%)
		leucine-rich repeat	75..99	CDD:275380	9/23 (39%)
		LRR_8	98..158	CDD:404697	15/59 (25%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..219	CDD:275380	3/22 (14%)
		LRRCT	228..277	CDD:214507	11/51 (22%)
		IG_like	294..390	CDD:214653	25/117 (21%)
		Ig strand B	296..300	CDD:409353	1/3 (33%)
		Ig strand C	309..323	CDD:409353	2/15 (13%)
		Ig strand E	356..360	CDD:409353	1/3 (33%)
		Ig strand F	370..375	CDD:409353	2/4 (50%)
		Ig strand G	383..386	CDD:409353	0/2 (0%)
ISLR	NP_005536.1	leucine-rich repeat	32..51	CDD:275380	6/18 (33%)
		LRR	<50..>182	CDD:443914	42/157 (27%)
		LRR 1	51..72		9/20 (45%)
		leucine-rich repeat	52..75	CDD:275380	9/22 (41%)
		LRR 2	75..96		4/22 (18%)
		leucine-rich repeat	76..99	CDD:275380	4/22 (18%)
		LRR 3	99..122		8/22 (36%)
		leucine-rich repeat	100..123	CDD:275380	9/22 (41%)
		LRR 4	123..144		3/20 (15%)
		leucine-rich repeat	124..147	CDD:275380	5/22 (23%)
		LRR 5	147..168		7/44 (16%)
		leucine-rich repeat	148..171	CDD:275380	8/46 (17%)
		PCC	153..>227	CDD:188093	22/99 (22%)
		Ig	239..340	CDD:472250	25/117 (21%)
		Ig strand B	253..257	CDD:409546	1/3 (33%)
		Ig strand C	266..270	CDD:409546	0/3 (0%)
		Ig strand E	310..314	CDD:409546	1/3 (33%)
		Ig strand F	324..329	CDD:409546	2/4 (50%)