DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and Slit2

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_017454764.1	Gene:	Slit2 / 360272	RGDID:	69310	Length:	1542	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	111/456 - (24%)
Similarity:	191/456 - (41%)	Gaps:	70/456 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109
            |.|   || .|.||..|:|..||..:....:.|||:.|:|..:.:..|  ..|::|:.|.:....
  Rat    32 CSC---SG-STVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDF--AGLRHLRVLQLMENK 90

  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPN-VFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLH 173
            :..:.:.:|..|:.|..|.|:.|.| .|.|. :|...:|:..:.|:.|.:||:....||....:.
  Rat    91 ISTIERGAFQDLKELERLRLNRNNL-QLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIK 154

  Fly   174 KIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVENPWNCTCDLQM 238
            .::|..|::..|:..||..:..|..:.|:||.:|:|.|.||..:.||....|..|...|.|.|..
  Rat   155 NLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAW 219

  Fly   239 FRDFV-----IGMNLYTPPTSCHYPLQLRGRLWIEDQPEAFACKPK------IVYPTLSTSINTS 292
            ..|::     :|  ||   |.|..|..|||....|.|...|.|..:      .:.|:
  Rat   220 LSDWLRQRPRVG--LY---TQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPS-------- 271

  Fly   293 KENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQ-RIYIELLREDESKIRKFGHDVF-- 354
                   |.|...|   ||...:|.:.:.|.|.:..:... ...|..:|.:::.||......|
  Rat   272 -------CSVLHCP---IACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNSIRVIPPGAFSP 326

  Fly   355 ---VSRLTIVNARKSDEGVYTCLAENP-GGKDSVHISVVVQKDMERISLIDSNFFAIVCLIAMGF 415
               :.||.:.|.:.|:      ||.:. .|..|:: |:|:..:  :|:.:..:.|.       |.
  Rat   327 YKKLRRLDLSNNQISE------LAPDAFQGLRSLN-SLVLYGN--KITELPKSLFE-------GL 375

  Fly   416 LSMSILF---SLVTCLIFKRFKQFHPGQHTYLQPTSLPVQSPGSEEATAISALSSGVIRESKIVL 477
            .|:.:|.   :.:.||....|:..|......|....|...:.|:  .:|:.|:.:..:.::..:.
  Rat   376 FSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTVAKGT--FSALRAIQTMHLAQNPFIC 438

  Fly   478 D 478
            |
  Rat   439 D 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	7/23 (30%)
		LRR_8	99..158	CDD:290566	15/59 (25%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		leucine-rich repeat	124..147	CDD:275380	8/23 (35%)
		LRR_8	146..206	CDD:290566	16/59 (27%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		TPKR_C2	228..277	CDD:301599	17/53 (32%)
		IG_like	294..390	CDD:214653	22/102 (22%)
		Ig	296..387	CDD:143165	21/97 (22%)
Slit2	XP_017454764.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910