Protein Alignment kek4 and AMIGO2

DIOPT Version :10

• Sequence 1: NP_609615.2
• Gene: kek4 / 34718
• FlyBaseID: FBgn0032484
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_862830.1
• Gene: AMIGO2 / 347902
• HGNCID: 24073
• Length: 522
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 107/511 - (20%)
• Similarity: 179/511 - (35%)
• Gaps: 130/511 - (25%)

  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109
            |.|    ......|.|.:||.||..|...::.||||:|.|..| ::.::......|..|::|:..
Human    45 CIC----ATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLL-DSEWIPVSFAKLNTLILRHNN 104

  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHK 174
            :..::..||:                 ..||: .||.      |:.|.|:.:::.||:.||.|..
Human   105 ITSISTGSFS-----------------TTPNL-KCLD------LSSNKLKTVKNAVFQELKVLEV 145

  Fly   175 IELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVE------------ 227
            :.|..|.:..:|..||.|:..|.::||..|.||:..::.:....||..|..::
Human   146 LLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMH 210

  Fly   228 -----------------NPWNCTCDL---------QMFRDFVIGMNLYTPPTSCHYPLQLRGRLW 266
                             ||:.|.|.|         :.|...:...|.||    |        |||
Human   211 HINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYT----C--------RLW 263

  Fly   267 IED---------QPEAFACKPKIVYPTLSTSINTSKENVTLICRVH-----GSPNTVIAW-DYTN 316
            .:.         |.....|...|:..:........:..|.....||     |:.||...| ...|
Human   264 SDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDN 328

  Fly   317 QVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGK 381
            ::.|    |.|.::...::               |:   ..|.|.:.|..|.|||:|:|.|....
Human   329 RLLE----PDKEMENFYVF---------------HN---GSLVIESPRFEDAGVYSCIAMNKQRL 371

  Fly   382 DSVHISVVVQKDMERIS------LIDSNFFAIVCLIAMGFLSMSILFSLVTCLIFKRFKQFHPGQ 440
            .:..:.|.:......:|      ..::.|..:...:|...|.:..|: |..|....:.|:    |
Human   372 LNETVDVTINVSNFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLY-LTPCPCKCKTKR----Q 431

  Fly   441 HTYLQPTSL--PVQSPGSEEATAISALSSGVIRESKIVLDPLSAINEPSNKNYTLF 494
            ...|..::.  .:.|||.....:.....:|. .:..:.|:||.......|....||
Human   432 KNMLHQSNAHSSILSPGPASDASADERKAGA-GKRVVFLEPLKDTAAGQNGKVRLF 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_609615.2	LRR	59..>228	CDD:443914	45/197 (23%)
		leucine-rich repeat	75..99	CDD:275380	7/23 (30%)
		LRR_8	98..158	CDD:404697	11/59 (19%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	4/22 (18%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		LRRCT	228..277	CDD:214507	14/66 (21%)
		IG_like	294..390	CDD:214653	23/101 (23%)
		Ig strand B	296..300	CDD:409353	1/3 (33%)
		Ig strand C	309..323	CDD:409353	3/14 (21%)
		Ig strand E	356..360	CDD:409353	1/3 (33%)
		Ig strand F	370..375	CDD:409353	3/4 (75%)
		Ig strand G	383..386	CDD:409353	0/2 (0%)
AMIGO2	NP_862830.1	LRR	<51..>230	CDD:443914	47/203 (23%)
		leucine-rich repeat	51..72	CDD:275380	7/20 (35%)
		LRR 1	69..90		7/21 (33%)
		leucine-rich repeat	73..95	CDD:275380	7/22 (32%)
		LRR 2	94..115		5/37 (14%)
		leucine-rich repeat	97..118	CDD:275380	4/37 (11%)
		LRR 3	118..139		8/27 (30%)
		leucine-rich repeat	119..142	CDD:275380	8/29 (28%)
		LRR 4	142..163		6/20 (30%)
		leucine-rich repeat	143..166	CDD:275380	7/22 (32%)
		LRR 5	166..187		6/20 (30%)
		leucine-rich repeat	167..193	CDD:275380	8/25 (32%)
		LRR 6	193..214		1/20 (5%)
		leucine-rich repeat	194..219	CDD:275380	1/24 (4%)
		LRRCT	228..283	CDD:214507	14/66 (21%)
		IG_like	298..380	CDD:214653	23/103 (22%)
		Ig strand B	306..310	CDD:409353	1/3 (33%)
		Ig strand C	320..324	CDD:409353	0/3 (0%)
		Ig strand E	338..342	CDD:409353	0/3 (0%)
		Ig strand F	360..365	CDD:409353	3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..522