DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and LRIT2

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001271152.1	Gene:	LRIT2 / 340745	HGNCID:	23443	Length:	560	Species:	Homo sapiens

Alignment Length:	536	Identity:	123/536 - (22%)
Similarity:	205/536 - (38%)	Gaps:	147/536 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LFKIYCLALIFRSASADWLLDCGNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIF 85
            :|..:.|.|:|....|........|.|...|..:|..|.::||..:|..||.|.:.:.:.::.:|
Human     4 VFHYFLLVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLF 68

  Fly    86 YLEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRA 150
            .:.:.:|            |...||:||            .|:.:|..::.|  ...:.|.::|.
Human    69 EMPQGSF------------INMSTLEYL------------WLNFNNISVIHL--GALEHLPELRE 107

  Fly   151 IFLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESF- 214
            :.|.||.|.::....||....|..::||||::.::...|...:..|:.:.|.:|.||.:....|
Human   108 LRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFL 172

  Fly   215 --------------QDLTKLTALSLVENPWNCTCDLQMFRDF-------VIGMNLYTPPTSCHYP 258
                          .::.....::|.:|||.|.|.|:....|       ||.:|.|   ..|..|
Human   173 NWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSY---LICQGP 234

  Fly   259 LQLRGRLWIEDQPEAFAC-KPKIVYPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESR 322
            |...|:|:.|  .|..|| ||:|..|:.:.:|... :||||.|....||:..|||.|.
Human   235 LSKAGQLFHE--TELSACMKPQISTPSANITIRAG-QNVTLRCLAQASPSPSIAWTYP------- 289

  Fly   323 SKPVKSLQKQRIYIELLREDESKI----------RKFGHDVFVSRLTIVNARKSDEGVYTCLAEN 377
                         :.:.||.:..:          ...|.|..:|.|.|..|...|.|.|||:|.|
Human   290 -------------LSMWREFDGLLGGKHLTPVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASN 341

  Fly   378 PGGKDSVHISVVVQKDMERISLIDSNFFAIVCLIAMGFLSMSILFSLVTCLIFKRFKQFHPGQHT 442
            ..||.::.||:.||                                              |.|..
Human   342 SIGKSNLVISLHVQ----------------------------------------------PAQAL 360

  Fly   443 YLQPTSLPVQSPGSEEATAISALSSGVIRES--KIVLDPLSAINEPSNKNYTLFKTSN-SNGSEY 504
            : .|.||.:.|.|:      :.:...|::::  .|:|:.|:..:....:.:||:..|: :...|.
Human   361 H-APDSLSIPSEGN------AYIDLRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEV 418

  Fly   505 MHTRNYKDVRLNSNTY 520
            :|      :....|||
Human   419 VH------IGPGINTY 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	2/23 (9%)
		LRR_8	99..158	CDD:290566	13/58 (22%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	4/22 (18%)
		LRR_8	146..206	CDD:290566	16/59 (27%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	6/37 (16%)
		TPKR_C2	228..277	CDD:301599	20/56 (36%)
		IG_like	294..390	CDD:214653	30/105 (29%)
		Ig	296..387	CDD:143165	27/100 (27%)
LRIT2	NP_001271152.1	leucine-rich repeat	37..55	CDD:275380	6/17 (35%)
		leucine-rich repeat	58..80	CDD:275378	3/33 (9%)
		LRR_8	60..115	CDD:290566	15/80 (19%)
		LRR_RI	<75..164	CDD:238064	26/114 (23%)
		LRR 1	80..103		7/36 (19%)
		LRR_4	81..119	CDD:289563	12/51 (24%)
		leucine-rich repeat	81..104	CDD:275378	7/36 (19%)
		LRR_8	103..163	CDD:290566	16/59 (27%)
		LRR 2	104..125		6/20 (30%)
		leucine-rich repeat	105..128	CDD:275378	7/22 (32%)
		LRR 3	128..149		6/20 (30%)
		leucine-rich repeat	129..152	CDD:275378	6/22 (27%)
		LRR 4	152..173		6/20 (30%)
		leucine-rich repeat	153..164	CDD:275378	3/10 (30%)
		leucine-rich repeat	193..204	CDD:275378	4/10 (40%)
		TPKR_C2	200..243	CDD:301599	16/45 (36%)
		I-set	253..354	CDD:254352	34/121 (28%)
		IGc2	267..344	CDD:197706	26/97 (27%)
		FN3	377..440	CDD:214495	12/58 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAUD
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810