Protein Alignment kek4 and LRIT2

DIOPT Version :10

• Sequence 1: NP_609615.2
• Gene: kek4 / 34718
• FlyBaseID: FBgn0032484
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001271152.1
• Gene: LRIT2 / 340745
• HGNCID: 23443
• Length: 560
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 123/536 - (22%)
• Similarity: 205/536 - (38%)
• Gaps: 147/536 - (27%)

  Fly    21 LFKIYCLALIFRSASADWLLDCGNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIF 85
            :|..:.|.|:|....|........|.|...|..:|..|.::||..:|..||.|.:.:.:.::.:|
Human     4 VFHYFLLVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQVRIENSPLF 68

  Fly    86 YLEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRA 150
            .:.:.:|            |...||:||            .|:.:|..::.|  ...:.|.::|.
Human    69 EMPQGSF------------INMSTLEYL------------WLNFNNISVIHL--GALEHLPELRE 107

  Fly   151 IFLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESF- 214
            :.|.||.|.::....||....|..::||||::.::...|...:..|:.:.|.:|.||.:....|
Human   108 LRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFL 172

  Fly   215 --------------QDLTKLTALSLVENPWNCTCDLQMFRDF-------VIGMNLYTPPTSCHYP 258
                          .::.....::|.:|||.|.|.|:....|       ||.:|.|   ..|..|
Human   173 NWPAYQKCRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSY---LICQGP 234

  Fly   259 LQLRGRLWIEDQPEAFAC-KPKIVYPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESR 322
            |...|:|:.|  .|..|| ||:|..|:.:.:|... :||||.|....||:..|||.|.
Human   235 LSKAGQLFHE--TELSACMKPQISTPSANITIRAG-QNVTLRCLAQASPSPSIAWTYP------- 289

  Fly   323 SKPVKSLQKQRIYIELLREDESKI----------RKFGHDVFVSRLTIVNARKSDEGVYTCLAEN 377
                         :.:.||.:..:          ...|.|..:|.|.|..|...|.|.|||:|.|
Human   290 -------------LSMWREFDGLLGGKHLTPVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASN 341

  Fly   378 PGGKDSVHISVVVQKDMERISLIDSNFFAIVCLIAMGFLSMSILFSLVTCLIFKRFKQFHPGQHT 442
            ..||.::.||:.||                                              |.|..
Human   342 SIGKSNLVISLHVQ----------------------------------------------PAQAL 360

  Fly   443 YLQPTSLPVQSPGSEEATAISALSSGVIRES--KIVLDPLSAINEPSNKNYTLFKTSN-SNGSEY 504
            : .|.||.:.|.|:      :.:...|::::  .|:|:.|:..:....:.:||:..|: :...|.
Human   361 H-APDSLSIPSEGN------AYIDLRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEV 418

  Fly   505 MHTRNYKDVRLNSNTY 520
            :|      :....|||
Human   419 VH------IGPGINTY 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_609615.2	LRR	59..>228	CDD:443914	37/183 (20%)
		leucine-rich repeat	75..99	CDD:275380	2/23 (9%)
		LRR_8	98..158	CDD:404697	13/59 (22%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	4/22 (18%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	6/37 (16%)
		LRRCT	228..277	CDD:214507	20/56 (36%)
		IG_like	294..390	CDD:214653	30/105 (29%)
		Ig strand B	296..300	CDD:409353	3/3 (100%)
		Ig strand C	309..323	CDD:409353	4/13 (31%)
		Ig strand E	356..360	CDD:409353	2/3 (67%)
		Ig strand F	370..375	CDD:409353	3/4 (75%)
		Ig strand G	383..386	CDD:409353	0/2 (0%)
LRIT2	NP_001271152.1	LRR	<37..>173	CDD:443914	38/161 (24%)
		leucine-rich repeat	37..55	CDD:275380	6/17 (35%)
		leucine-rich repeat	58..80	CDD:275378	3/33 (9%)
		LRR 1	80..103		7/36 (19%)
		leucine-rich repeat	81..104	CDD:275378	7/36 (19%)
		LRR_8	103..163	CDD:404697	16/59 (27%)
		LRR 2	104..125		6/20 (30%)
		leucine-rich repeat	105..128	CDD:275378	7/22 (32%)
		LRR 3	128..149		6/20 (30%)
		leucine-rich repeat	129..152	CDD:275378	6/22 (27%)
		LRR 4	152..173		6/20 (30%)
		leucine-rich repeat	153..164	CDD:275378	3/10 (30%)
		leucine-rich repeat	193..204	CDD:275378	4/10 (40%)
		LRRCT	200..243	CDD:214507	16/45 (36%)
		Ig_3	252..341	CDD:464046	30/109 (28%)
		FN3	377..440	CDD:214495	12/58 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	518..560