DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and LINGO4

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001004432.1	Gene:	LINGO4 / 339398	HGNCID:	31814	Length:	593	Species:	Homo sapiens

Alignment Length:	592	Identity:	116/592 - (19%)
Similarity:	185/592 - (31%)	Gaps:	203/592 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GNCH--CKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLI 105
            |:|.  |...|..:...|.:..|..||..|..:.::||||.|.::.|::.  :.:.|..||:|.:
Human    29 GSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQG--MLSRLSLLQELDL 91

  Fly   106 RNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLK 170
            ....|..|...:|..||.|:.|.|..|.|..:.|.||..||.:..:.|..|.:.....|.|..|.
Human    92 SYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELG 156

  Fly   171 YLHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNE------------------------------ 205
            .|.|:|:..|.||.:...||.|:..||.:.|:...
Human   157 SLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPA 221

  Fly   206 ----------------------------------------------------------------- 205

Human   222 GALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQN 286

  Fly   206 -------------------------LTKLRVESFQDLT------------------------KLT 221
                                     ||.:...:|..||                        ||.
Human   287 PISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLV 351

  Fly   222 ALSLVENPWNCTCD----LQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIEDQ----PEAFACKP 278
            .|.|..||..|.|.    |::.|....||:    |.:|..|..::|:...|..    |..|.|||
Human   352 TLRLSGNPLTCDCRLLWLLRLRRHLDFGMS----PPACAGPHHVQGKSLKEFSDILPPGHFTCKP 412

  Fly   279 KIVYPTLSTSINTSK-ENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLRED 342
            .::..:....:...: .:....|...|.|...::|...:..:..|:..|:.|           ||
Human   413 ALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVL-----------ED 466

  Fly   343 ESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISV-VVQKDMERISLIDSN--- 403
                         ..|.|.:.:..|.|.|.|:..|..|.||:...: |:|.:....:|.|.|
Human   467 -------------GTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNITV 518

  Fly   404 ------FF----AIVCLIAMGFL----SMSILFSLVTCLIFKRFKQFHPGQHTYLQPTSLPVQSP 454
                  ||    .:..::|:|||    |:::.|.|:......:.:..|.....::.|.....::.
Human   519 PGIPGPFFLDSRGVAMVLAVGFLPFLTSVTLCFGLIALWSKGKGRVKHHMTFDFVAPRPSGDKNS 583

  Fly   455 GSEEATA 461
            |....||
Human   584 GGNRVTA 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	7/23 (30%)
		LRR_8	99..158	CDD:290566	20/58 (34%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		LRR_8	146..206	CDD:290566	18/179 (10%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..195	CDD:275380	9/22 (41%)
		leucine-rich repeat	196..219	CDD:275380	8/166 (5%)
		TPKR_C2	228..277	CDD:301599	15/56 (27%)
		IG_like	294..390	CDD:214653	19/96 (20%)
		Ig	296..387	CDD:143165	19/90 (21%)
LINGO4	NP_001004432.1	LRRNT	31..64	CDD:214470	8/32 (25%)
		leucine-rich repeat	62..85	CDD:275380	7/24 (29%)
		LRR_8	65..120	CDD:290566	19/56 (34%)
		leucine-rich repeat	86..109	CDD:275380	7/22 (32%)
		LRR_RI	87..320	CDD:238064	36/232 (16%)
		LRR_8	109..168	CDD:290566	19/58 (33%)
		leucine-rich repeat	110..133	CDD:275380	9/22 (41%)
		leucine-rich repeat	134..157	CDD:275380	5/22 (23%)
		LRR_8	157..212	CDD:290566	12/54 (22%)
		leucine-rich repeat	158..181	CDD:275380	9/22 (41%)
		leucine-rich repeat	182..205	CDD:275380	3/22 (14%)
		leucine-rich repeat	206..229	CDD:275380	0/22 (0%)
		leucine-rich repeat	230..277	CDD:275380	0/46 (0%)
		LRR_8	253..309	CDD:290566	0/55 (0%)
		leucine-rich repeat	278..301	CDD:275380	0/22 (0%)
		LRR_8	301..360	CDD:290566	10/58 (17%)
		leucine-rich repeat	302..325	CDD:275380	4/22 (18%)
		leucine-rich repeat	326..344	CDD:275380	0/17 (0%)
		leucine-rich repeat	350..362	CDD:275378	5/11 (45%)
		IG_like	420..501	CDD:214653	19/104 (18%)
		Ig	431..501	CDD:299845	19/93 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910