DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and Tlr9

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_937764.1	Gene:	Tlr9 / 338457	RGDID:	631352	Length:	1032	Species:	Rattus norvegicus

Alignment Length:	333	Identity:	81/333 - (24%)
Similarity:	122/333 - (36%)	Gaps:	106/333 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ISLKHLSLFLFKIYCLALIFRSASADWLLDCGNCHCKWNSGKKTADCRN-----LSLSGVPEYLS 71
            ::|.||.       ||:|            ..||..:..:|.:.....|     ||.:.:..|.|
  Rat   494 VNLSHLQ-------CLSL------------SHNCIAQAVNGSQFLPLTNLKVLDLSYNKLDLYHS 539

  Fly    72 ------PEVQVLDLSHN----------HIFYLEENAFLTTHLQNLQKLLIRNG------------ 108
                  |::|.||||:|          |.|     :|| .:|..||.|.:.:.
  Rat   540 KSFSELPQLQALDLSYNSQPFSMQGIGHNF-----SFL-ANLSRLQNLSLAHNDIHSRVSSRLYS 598

  Fly   109 -TLKYLNQRS----------------FTQLQILIELDLSNNLLVDLLPNVFDCLSK--------- 147
             :::||:...                |..|:.||.||||.|.|..|.|...:.|.|
  Rat   599 TSVEYLDFSGNGVGRMWDEEDLYLYFFQDLRSLIHLDLSQNKLHILRPQNLNYLPKSLTKLSFRD 663

  Fly   148 ----------------VRAIFLNGNLLQALRHGVFRNLKYLHKIELKRNRLVSIDAKAFVGVPLL 196
                            :|.:.|.||||:||.:|...|...|.|:::..|.:|.:....|.....|
  Rat   664 NHLSFFNWSSLAFLPNLRDLDLAGNLLKALTNGTLPNGTLLQKLDVSSNSIVFVVPAFFALAVEL 728

  Fly   197 SQIYLDNNELTKLRVESFQDLT-KLTALSLVENPWNCTCDLQMFRDFVIGMNLYTP----PTSCH 256
            .::.|.:|.|..:....|..:. .||.|.:..||.:|.|... |.|.::.:....|    ...|.
  Rat   729 KEVNLSHNILKTVDRSWFGPIVMNLTVLDVSSNPLHCACGAP-FVDLLLEVQTKVPGLANGVKCG 792

  Fly   257 YPLQLRGR 264
            .|.||:||
  Rat   793 SPRQLQGR 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	11/33 (33%)
		LRR_8	99..158	CDD:290566	23/112 (21%)
		leucine-rich repeat	100..123	CDD:275380	7/51 (14%)
		leucine-rich repeat	124..147	CDD:275380	11/22 (50%)
		LRR_8	146..206	CDD:290566	19/84 (23%)
		leucine-rich repeat	148..171	CDD:275380	10/22 (45%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..219	CDD:275380	5/23 (22%)
		TPKR_C2	228..277	CDD:301599	13/41 (32%)
		IG_like	294..390	CDD:214653
		Ig	296..387	CDD:143165
Tlr9	NP_937764.1	leucine-rich repeat	43..64	CDD:275380
		LRR_8	63..135	CDD:290566
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..124	CDD:275380
		LRR_RI	123..373	CDD:238064
		leucine-rich repeat	125..144	CDD:275380
		LRR_8	143..211	CDD:290566
		leucine-rich repeat	145..168	CDD:275380
		leucine-rich repeat	169..200	CDD:275380
		LRR_8	199..254	CDD:290566
		leucine-rich repeat	201..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		leucine-rich repeat	246..285	CDD:275380
		LRR_8	284..344	CDD:290566
		leucine-rich repeat	286..309	CDD:275380
		LRR_RI	310..556	CDD:238064	20/80 (25%)
		leucine-rich repeat	310..335	CDD:275380
		leucine-rich repeat	336..365	CDD:275380
		leucine-rich repeat	393..416	CDD:275380
		leucine-rich repeat	477..498	CDD:275380	1/3 (33%)
		LRR_RI	<490..692	CDD:238064	51/222 (23%)
		LRR_8	497..556	CDD:290566	19/77 (25%)
		leucine-rich repeat	499..523	CDD:275380	7/42 (17%)
		leucine-rich repeat	524..547	CDD:275380	4/22 (18%)
		leucine-rich repeat	548..577	CDD:275380	11/34 (32%)
		leucine-rich repeat	578..630	CDD:275380	7/51 (14%)
		leucine-rich repeat	601..618	CDD:275380	2/16 (13%)
		LRR_8	629..690	CDD:290566	16/60 (27%)
		leucine-rich repeat	631..655	CDD:275380	11/23 (48%)
		leucine-rich repeat	656..679	CDD:275380	0/22 (0%)
		leucine-rich repeat	680..703	CDD:275380	10/22 (45%)
		LRR_8	704..763	CDD:290566	14/58 (24%)
		leucine-rich repeat	704..727	CDD:275380	5/22 (23%)
		leucine-rich repeat	728..746	CDD:275380	4/17 (24%)
		leucine-rich repeat	753..774	CDD:275380	8/21 (38%)
		TIR_2	870..1013	CDD:304906
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910