DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek4 and Lingo4

DIOPT Version :9

Sequence 1:NP_001260435.1 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_796224.1 Gene:Lingo4 / 320747 MGIID:2444651 Length:618 Species:Mus musculus


Alignment Length:538 Identity:111/538 - (20%)
Similarity:178/538 - (33%) Gaps:181/538 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 EVQVLDLSHNHIFYLEENAFLTTH-LQNLQKLLIRNGTLKY------------------LNQ--- 115
            ::|.||||:|.:..||..||   | ||:|..|.::...|:.                  |||   
Mouse   110 QLQELDLSYNQLSTLEPGAF---HGLQSLLTLRLQGNRLRIVGPGIFSGLTALTLLDLRLNQIVL 171

  Fly   116 ---RSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLN----------------------- 154
               .:|::|..|.:|::.:|.||.:.|..|..|:|:..|.|.                       
Mouse   172 FLDGAFSELGSLQQLEVGDNHLVFVAPGAFAGLAKLSTITLERCNLSTVPGLALAQLPALVALRL 236

  Fly   155 -----------------------------------GNLL-------------------QALRHGV 165
                                               |:|:                   |||.|  
Mouse   237 RELDIERLPAGALRGLGQLKELEIHHWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALHH-- 299

  Fly   166 FRNLKYLHKIELKRNR------------------------LVSIDAKAFVGVPLLSQIYLDNNEL 206
               |.:|..::|.:|.                        |.||.|.||.|:.....:.:.:|.|
Mouse   300 ---LSFLRILDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNAL 361

  Fly   207 TKLRVESFQDLTKLTALSLVENPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIEDQ- 270
            ..|...:|....||..|.|..||..|.|.|.........::..|.|.:|..|..::|:...|.. 
Mouse   362 QTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRRLDFGTSPPACAGPQHVQGKSLREFSD 426

  Fly   271 ---PEAFACKPKIVYPTLSTSINTSK-ENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQK 331
               |..|.|||.::..:....:...: .:....|...|.|...::|......:..|...|:.|  
Mouse   427 ILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPQGAWLGRVGRVRVL-- 489

  Fly   332 QRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISV-VVQKDME 395
                     ||             ..|.|.:.:..|.|.|.|:..|..|.||:...: |:|.:..
Mouse   490 ---------ED-------------GTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPP 532

  Fly   396 RISLIDSN---------FF----AIVCLIAMGFL----SMSILFSLVTCLIFKRFKQFHPGQHTY 443
            ..:|.|.|         ||    .:..::|:|||    |:::.|.|:......:.:..|.....:
Mouse   533 NGTLSDPNITMPGIPGPFFLDSRGVAMVLAVGFLPFLTSVTLCFGLIALWSKGKGRVKHHMTFDF 597

  Fly   444 LQPTSLPVQSPGSEEATA 461
            :.|.....::.|....||
Mouse   598 VAPRPSGDKNSGGNRVTA 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_001260435.1 leucine-rich repeat 75..99 CDD:275380 12/24 (50%)
LRR_8 99..158 CDD:290566 20/140 (14%)
leucine-rich repeat 100..123 CDD:275380 8/46 (17%)
leucine-rich repeat 124..147 CDD:275380 8/22 (36%)
LRR_8 146..206 CDD:290566 21/160 (13%)
leucine-rich repeat 148..171 CDD:275380 9/99 (9%)
leucine-rich repeat 172..195 CDD:275380 10/46 (22%)
leucine-rich repeat 196..219 CDD:275380 4/22 (18%)
TPKR_C2 228..277 CDD:301599 13/52 (25%)
IG_like 294..390 CDD:214653 19/96 (20%)
Ig 296..387 CDD:143165 19/90 (21%)
Lingo4NP_796224.1 LRRNT 56..89 CDD:214470
leucine-rich repeat 69..86 CDD:275380
leucine-rich repeat 87..110 CDD:275380 111/538 (21%)
LRR_8 90..145 CDD:290566 15/37 (41%)
leucine-rich repeat 111..134 CDD:275380 12/25 (48%)
LRR_RI 112..345 CDD:238064 46/240 (19%)
LRR_8 134..193 CDD:290566 11/58 (19%)
leucine-rich repeat 135..158 CDD:275380 3/22 (14%)
leucine-rich repeat 159..182 CDD:275380 5/22 (23%)
LRR_8 182..237 CDD:290566 11/54 (20%)
leucine-rich repeat 183..206 CDD:275380 8/22 (36%)
leucine-rich repeat 207..230 CDD:275380 2/22 (9%)
leucine-rich repeat 231..254 CDD:275380 0/22 (0%)
leucine-rich repeat 255..302 CDD:275380 7/51 (14%)
LRR_8 278..334 CDD:290566 8/60 (13%)
leucine-rich repeat 303..326 CDD:275380 3/22 (14%)
LRR_8 326..385 CDD:290566 16/58 (28%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
leucine-rich repeat 351..369 CDD:275380 3/17 (18%)
leucine-rich repeat 375..387 CDD:275378 5/11 (45%)
IG_like 445..526 CDD:214653 19/104 (18%)
Ig 456..526 CDD:299845 19/93 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8825
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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