DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and Lrfn2

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001034788.1	Gene:	Lrfn2 / 316205	RGDID:	1311831	Length:	788	Species:	Rattus norvegicus

Alignment Length:	383	Identity:	85/383 - (22%)
Similarity:	139/383 - (36%)	Gaps:	68/383 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109
            |.|:..|......|.:..|..||..:......|.|..|.|.::....|  .::..|..|.:...|
  Rat    25 CVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHIGRQDF--ANMTGLVDLTLSRNT 87

  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRN-LKYLH 173
            :.::...||..|:.|..|.|.:|.|..|..:....|..::.:.:|.|.|..:....|.: |..|.
  Rat    88 ISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADDAFEDFLLTLE 152

  Fly   174 KIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVE----------- 227
            .::|..|.|..:...:...:..|.|:.||:|.|..:...:|.||.||..|.|..
  Rat   153 DLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPI 217

  Fly   228 ------------------------NPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIE 268
                                    ||.:|.|:|...|......:|.|    |..|..|:||.:..
  Rat   218 FARSQASLLTATPFAPPLSFSFGGNPLHCNCELLWLRRLERDDDLET----CGSPGGLKGRYFWH 278

  Fly   269 DQPEAFACKPKIVYPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQR 333
            .:.|.|.|:|.::.......:....:..||.|:..|.|:.:|.|      .....:.|.:..:..
  Rat   279 IREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHW------VAPDDRLVGNSSRTA 337

  Fly   334 IYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGK--DSVHISVV 389
            :|..                  ..|.|:.....|.|.:||:|.|..|:  .:|.:|:|
  Rat   338 VYDN------------------GTLDILITTSQDSGPFTCIAANAAGEATATVEVSIV 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	5/23 (22%)
		LRR_8	99..158	CDD:290566	15/58 (26%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR_8	146..206	CDD:290566	14/60 (23%)
		leucine-rich repeat	148..171	CDD:275380	5/23 (22%)
		leucine-rich repeat	172..195	CDD:275380	4/22 (18%)
		leucine-rich repeat	196..219	CDD:275380	9/22 (41%)
		TPKR_C2	228..277	CDD:301599	15/48 (31%)
		IG_like	294..390	CDD:214653	21/98 (21%)
		Ig	296..387	CDD:143165	19/92 (21%)
Lrfn2	NP_001034788.1	LRR_RI	27..>209	CDD:238064	46/183 (25%)
		LRR 1	53..74		5/22 (23%)
		leucine-rich repeat	54..77	CDD:275380	5/24 (21%)
		LRR_8	76..136	CDD:290566	15/59 (25%)
		LRR 2	77..98		5/20 (25%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		LRR 3	101..122		6/20 (30%)
		leucine-rich repeat	102..125	CDD:275380	7/22 (32%)
		LRR_8	125..185	CDD:290566	14/59 (24%)
		LRR 4	125..146		4/20 (20%)
		leucine-rich repeat	126..150	CDD:275380	5/23 (22%)
		LRR 5	150..171		4/20 (20%)
		leucine-rich repeat	151..174	CDD:275380	4/22 (18%)
		LRR_8	174..>215	CDD:290566	13/40 (33%)
		LRR 6	174..195		7/20 (35%)
		leucine-rich repeat	175..198	CDD:275380	9/22 (41%)
		LRR 7	198..219		4/20 (20%)
		LRRCT	242..286	CDD:214507	15/47 (32%)
		IG_like	298..376	CDD:214653	19/101 (19%)
		Ig	303..376	CDD:299845	19/96 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..423
		fn3	428..493	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..655
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..707
		PDZ-binding	785..788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910