DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek4 and Lingo1

DIOPT Version :9

Sequence 1:NP_001260435.1 Gene:kek4 / 34718 FlyBaseID:FBgn0032484 Length:649 Species:Drosophila melanogaster
Sequence 2:NP_001094192.1 Gene:Lingo1 / 315691 RGDID:1308668 Length:620 Species:Rattus norvegicus


Alignment Length:587 Identity:116/587 - (19%)
Similarity:190/587 - (32%) Gaps:206/587 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 LALIFRSASADWLLDC-GNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEEN 90
            |.|:..|..:.....| ..|.|  ::..:...|.......|||.:..|.::|||..|.|..|.::
  Rat    27 LLLVLGSVLSGSATGCPPRCEC--SAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQD 89

  Fly    91 AFLT-THLQ---------------------NLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNL 133
            .|.: .||:                     ||:.|.:|:..||.:....||.|..|.:||:|.|.
  Rat    90 EFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENK 154

  Fly   134 LVDLLPNVFDCLSKVRAI----------------------------------------------- 151
            :|.||..:|..|..::::                                               
  Rat   155 IVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIV 219

  Fly   152 ----FLNGNLLQ--------------------------------------------------ALR 162
                .||.|.::                                                  |:|
  Rat   220 LRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVR 284

  Fly   163 HGV---FRNLKY----------------LHKIELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTK 208
            |.|   |.||.|                |.:|:|...:|..::..||.|:..|..:.:..|:||.
  Rat   285 HLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTT 349

  Fly   209 LRVESFQDLTKLTALSLVENPWNCTCDLQMF--RDFVIGMNLYTPPTSCHYPLQLRGRLWIEDQP 271
            |...:|..:..|..|.|..||..|.|.|...  |.:.:..|...|  :|..|..::|:.: :|.|
  Rat   350 LEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQP--TCATPEFVQGKEF-KDFP 411

  Fly   272 EA-----FACKPKIVYPTLSTSINTSK-ENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQ 330
            :.     |.|:...:....:..:...: ..|..:||..|.|...|.|          ..|.|.| 
  Rat   412 DVLLPNYFTCRRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILW----------LSPRKHL- 465

  Fly   331 KQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQ---- 391
                   :..:...::..|..    ..|.:..|:..|.|.|.|:|.|.||.||:...:.|:    
  Rat   466 -------VSAKSNGRLTVFPD----GTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSP 519

  Fly   392 ----KDMERISLIDS------------------NFFAIVCLIAMGFLSM--SILFSLVTCLIFKR 432
                :..:..:.|.:                  :...::....|||:|.  .:||.||...::.|
  Rat   520 DWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSR 584

  Fly   433 FK 434
            .|
  Rat   585 GK 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek4NP_001260435.1 leucine-rich repeat 75..99 CDD:275380 9/45 (20%)
LRR_8 99..158 CDD:290566 22/109 (20%)
leucine-rich repeat 100..123 CDD:275380 8/22 (36%)
leucine-rich repeat 124..147 CDD:275380 10/22 (45%)
LRR_8 146..206 CDD:290566 20/179 (11%)
leucine-rich repeat 148..171 CDD:275380 10/126 (8%)
leucine-rich repeat 172..195 CDD:275380 7/22 (32%)
leucine-rich repeat 196..219 CDD:275380 6/22 (27%)
TPKR_C2 228..277 CDD:301599 14/55 (25%)
IG_like 294..390 CDD:214653 23/95 (24%)
Ig 296..387 CDD:143165 23/90 (26%)
Lingo1NP_001094192.1 LRRNT 41..75 CDD:214470 8/35 (23%)
LRR <66..371 CDD:227223 59/304 (19%)
leucine-rich repeat 73..96 CDD:275380 7/22 (32%)
leucine-rich repeat 97..120 CDD:275380 1/22 (5%)
LRR_8 120..179 CDD:404697 19/58 (33%)
leucine-rich repeat 121..144 CDD:275380 8/22 (36%)
leucine-rich repeat 145..192 CDD:275380 10/46 (22%)
leucine-rich repeat 193..216 CDD:275380 0/22 (0%)
leucine-rich repeat 217..264 CDD:275380 3/46 (7%)
leucine-rich repeat 265..288 CDD:275380 3/22 (14%)
leucine-rich repeat 289..312 CDD:275380 4/22 (18%)
leucine-rich repeat 313..336 CDD:275380 7/22 (32%)
leucine-rich repeat 337..357 CDD:275380 6/19 (32%)
PCC 341..>421 CDD:188093 22/82 (27%)
IgI_Lingo-1 423..514 CDD:409561 23/112 (21%)
Ig strand B 442..446 CDD:409561 1/3 (33%)
Ig strand C 455..459 CDD:409561 2/13 (15%)
Ig strand E 480..484 CDD:409561 1/3 (33%)
Ig strand F 494..499 CDD:409561 2/4 (50%)
Ig strand G 507..510 CDD:409561 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46071
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.