Protein Alignment kek4 and Lingo2

DIOPT Version :10

• Sequence 1: NP_609615.2
• Gene: kek4 / 34718
• FlyBaseID: FBgn0032484
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001101396.1
• Gene: Lingo2 / 313156
• RGDID: 1310773
• Length: 606
• Species: Rattus norvegicus
• Alignment Length: 656
• Identity: 125/656 - (19%)
• Similarity: 199/656 - (30%)
• Gaps: 284/656 - (43%)

  Fly    27 LALIFRSASADWLLDC-GNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEEN 90
            :.|:|..::    :.| ..|.|  ::..|:..|....|..:||.:..|.::||||.|.
  Rat    17 MVLLFMGST----IGCPARCEC--SAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNR------- 68

  Fly    91 AFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNG 155
                               ||.:|...|....:|.|:|||:|::.::.|..|:.|..:|::.|.|
  Rat    69 -------------------LKSINPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKG 114

  Fly   156 NLLQALRHGVFRNLKYLHKIELKRNR------------------------LVSIDAKAFVGVPLL 196
            |.|:.:..|||..|..|.|:::..|:                        ||.|..:||.|:..|
  Rat   115 NRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLFSL 179

  Fly   197 SQIYLDNNELTKLRVE------------------------------------------------- 212
            .|:.|:...||.:..|
  Rat   180 EQLTLEKCNLTAVPTEALSHLRSLITLHLKHLNINNMPVYAFKRLFHLKQLEIDYWPLLDMMPAN 244

  Fly   213 -----------------------SFQDLTKLTALSLVENPWNCTCDLQMFRDF-------VIGMN 247
                                   :|:.|..||.|:|..||.: |.:..||.|.       |:|..
  Rat   245 SLYGLNLTSLSITNTNLSTVPFLAFKHLVYLTHLNLSYNPIS-TIEAGMFSDLIRLQELHVVGAQ 308

  Fly   248 LYT-------------------------------------------PPTSCHYPLQLRGRLWI-- 267
            |.|                                           .|.:|...|     ||:
  Rat   309 LRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRL-----LWLLQ 368

  Fly   268 --------EDQPEA----------------------FAC-KPKIVYPTLSTSINTSKENVTLICR 301
                    ..||..                      |.| ||||....|...:....:.|.|.|.
  Rat   369 RQATLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECN 433

  Fly   302 VHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKS 366
            ..|.|..||:|                :..:|.:|.......:.:...|      .|.|..|:..
  Rat   434 ADGDPQPVISW----------------VTPRRRFITTKSNGRATVLGDG------TLEIRFAQDQ 476

  Fly   367 DEGVYTCLAENPGGKDSVHISVVVQ---------KDMERISLIDSN---------------FFAI 407
            |.|:|.|:|.|..|.|:...|:.|:         .:...:.:.|||               ...|
  Rat   477 DSGMYVCIASNAAGNDTFTASLTVKGFTSDRFLYANRTPMYMTDSNDTVSNGTNANTFSLDLKTI 541

  Fly   408 VCLIAMG---FLSMSILFSLVTCLIFKRFKQFHPGQHTYLQPTSLPVQSPGSEEATAISALSSGV 469
            :...|||   ||.: :||..:...::.|.|    |:|            ..|.:...:...::|.
  Rat   542 LVSTAMGCFTFLGV-VLFCFLLLFVWSRGK----GKH------------KNSIDLEYVPRKNNGA 589

  Fly   470 IRESKI 475
            :.|.::
  Rat   590 VAEGEV 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_609615.2	LRR	59..>228	CDD:443914	52/264 (20%)
		leucine-rich repeat	75..99	CDD:275380	5/23 (22%)
		LRR_8	98..158	CDD:404697	17/59 (29%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		leucine-rich repeat	148..171	CDD:275380	9/22 (41%)
		leucine-rich repeat	172..195	CDD:275380	9/46 (20%)
		leucine-rich repeat	196..219	CDD:275380	8/94 (9%)
		LRRCT	228..277	CDD:214507	19/131 (15%)
		IG_like	294..390	CDD:214653	23/95 (24%)
		Ig strand B	296..300	CDD:409353	2/3 (67%)
		Ig strand C	309..323	CDD:409353	3/13 (23%)
		Ig strand E	356..360	CDD:409353	1/3 (33%)
		Ig strand F	370..375	CDD:409353	2/4 (50%)
		Ig strand G	383..386	CDD:409353	0/2 (0%)
Lingo2	NP_001101396.1	LRRNT	27..60	CDD:214470	9/34 (26%)
		leucine-rich repeat	39..57	CDD:275380	5/17 (29%)
		LRR	48..>340	CDD:443914	62/318 (19%)
		leucine-rich repeat	59..82	CDD:275380	9/48 (19%)
		leucine-rich repeat	83..106	CDD:275380	9/22 (41%)
		leucine-rich repeat	107..130	CDD:275380	9/22 (41%)
		leucine-rich repeat	131..154	CDD:275380	3/22 (14%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..202	CDD:275380	6/22 (27%)
		leucine-rich repeat	203..250	CDD:275380	0/46 (0%)
		leucine-rich repeat	251..274	CDD:275380	2/22 (9%)
		leucine-rich repeat	275..298	CDD:275380	10/23 (43%)
		leucine-rich repeat	299..322	CDD:275380	4/22 (18%)
		leucine-rich repeat	323..343	CDD:275380	0/19 (0%)
		PCC	327..>391	CDD:188093	7/68 (10%)
		Ig	411..500	CDD:472250	26/110 (24%)
		Ig strand B	428..432	CDD:409353	2/3 (67%)
		Ig strand C	441..445	CDD:409353	3/19 (16%)
		Ig strand E	466..470	CDD:409353	2/9 (22%)
		Ig strand F	480..485	CDD:409353	2/4 (50%)
		Ig strand G	493..496	CDD:409353	0/2 (0%)