DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek4 and Lrrc55

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001381943.1	Gene:	Lrrc55 / 311171	RGDID:	1561726	Length:	311	Species:	Rattus norvegicus

Alignment Length:	270	Identity:	69/270 - (25%)
Similarity:	105/270 - (38%)	Gaps:	44/270 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 HLSLFLFKIYCLALIFRS---ASADWLLDCGNCHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVL 77
            |.:|.|......|.:..|   ||...|..|.|         :..||.|..|..||..|..:.:.|
  Rat    28 HSALLLVFFLLAAGVMHSDAGASCPVLCTCRN---------QVVDCSNQRLFSVPPDLPMDTRNL 83

  Fly    78 DLSHNHIFYLEENAFLTTHLQNLQKLLIRNGTLKYLNQRSFTQLQILIELDLSNNLLVDLLPNVF 142
            .|:||.|..:.. .:||.:::                         |..|||.||.|::|.|.:|
  Rat    84 SLAHNRIAAVPP-GYLTCYME-------------------------LRVLDLRNNSLMELPPGLF 122

  Fly   143 DCLSKVRAIFLNGNLLQALRHGVFRNLKYLHKIELKRNR-LVSIDAKAFVGVPLLSQIYLDNNEL 206
            ....::..:.|:.|.|..:...:||....|..|:|..|. |..:..:||.|:..|..:.|....|
  Rat   123 LHAKRLAHLDLSYNNLSHVPADMFREAHGLVHIDLSHNPWLRRVHPQAFQGLVHLRDLDLSYGGL 187

  Fly   207 TKLRVESFQDLTKLTALSLVENPWNCTCD----LQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWI 267
            ..|.:|:.:.|..|..|.:..|||.|.|.    |:..|:.:......:....|..|.::.|....
  Rat   188 AFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLF 252

  Fly   268 EDQPEAF-AC 276
            ....|:| ||
  Rat   253 SLTEESFKAC 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	7/23 (30%)
		LRR_8	99..158	CDD:290566	12/58 (21%)
		leucine-rich repeat	100..123	CDD:275380	0/22 (0%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		LRR_8	146..206	CDD:290566	15/60 (25%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..195	CDD:275380	8/23 (35%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	14/54 (26%)
		IG_like	294..390	CDD:214653
		Ig	296..387	CDD:143165
Lrrc55	NP_001381943.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910