DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek4 and Slitrk3

DIOPT Version :9

Sequence 1:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001101153.1	Gene:	Slitrk3 / 310519	RGDID:	1310506	Length:	979	Species:	Rattus norvegicus

Alignment Length:	627	Identity:	130/627 - (20%)
Similarity:	225/627 - (35%)	Gaps:	201/627 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109
            |:...|....|.:|:....:.:.|.|...:                        |.:||.:.:..
  Rat   379 CNLHINDLGLTVNCKERGFNNISELLPRPL------------------------NAKKLYLSSNL 419

  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHK 174
            ::.:.:..|.....|..|.|.||.:..:....|..|..::::|||||.::.|..|:||.|:.||.
  Rat   420 IQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHY 484

  Fly   175 IELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESF------------------------Q 215
            :..:.|.:..|...||..:|.|..::|:||.|..|..::|                        :
  Rat   485 LYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLE 549

  Fly   216 DLTKLTALSLVENPWNCTCDLQMFRDFVIGMNLYTPPTSCHYPLQLRGRLWIEDQPEAFACKPKI 280
            .|..:..:.|.||||:|||||..|:.                        |||
  Rat   550 HLNAIVQIDLNENPWDCTCDLVPFKQ------------------------WIE------------ 578

  Fly   281 VYPTLSTSINTSKENVTLICRVHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESK 345
               |:| |::...:   ::||   :|..:...|            |::::     :|:|..:...
  Rat   579 ---TIS-SVSVVGD---VLCR---TPENLTHRD------------VRTIE-----LEVLCPEMLH 616

  Fly   346 IRKFGHDVFVSRLTIVNARKSDEGVYTCLAENPGGKDSVHISVVVQKDMERISLIDSNFFAIVCL 410
            |.:.|.....|.....|...:....|.  ...|||  .|.:||::      :||:...|.|:  .
  Rat   617 IAQPGPSPPQSGDYHPNGGPTSASPYD--FSPPGG--PVPLSVLI------LSLLVLFFSAV--F 669

  Fly   411 IAMGFLSMSILFSLVTCLIFKRFKQFHPGQHTYLQPTSLPVQSPGSEEATAISALSSGVIRESKI 475
            :|.|      ||:.|   :.:|.|:             ||.:|...|          ||
  Rat   670 VAAG------LFAYV---LRRRRKK-------------LPFRSKRQE----------GV------ 696

  Fly   476 VLDPLSAINEPSNKNYTLFKTSNSNGSEYMHTRNYKDVRLNSNTYTENLDNQAESISSRNRELYS 540
               .|:.|....::   ||:.|..:|.   .:.:.....|:|......:.:..|.|.....::.:
  Rat   697 ---DLTGIQMQCHR---LFEDSGGSGG---GSGSGGRPTLSSPEKAPPVGHVYEYIPHPVTQMCN 752

  Fly   541 N-IAGDREKEELKQKDELDKDSRQSSLQSTGCSRKKGQIDELQPDLLPSTQPTALKNI---NETF 601
            | |...||:||:          ..|:.|.||.:.:.|          |.|||..:..:   :|.|
  Rat   753 NPIYKPREEEEV----------AASAAQDTGATDRGG----------PGTQPPGMGEVLLGSEQF 797

  Fly   602 GPSAKKAEVNPRSKYNTNVQKYLKEKYGSVRIKNISTKEPIT 643
            ..:.|:    ..|.|.|.::   |||..::.:.|......:|
  Rat   798 AETPKE----NHSNYRTLLE---KEKEWALAVSNSQLNTIVT 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	0/23 (0%)
		LRR_8	99..158	CDD:290566	16/58 (28%)
		leucine-rich repeat	100..123	CDD:275380	3/22 (14%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR_8	146..206	CDD:290566	21/59 (36%)
		leucine-rich repeat	148..171	CDD:275380	10/22 (45%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..219	CDD:275380	8/46 (17%)
		TPKR_C2	228..277	CDD:301599	12/48 (25%)
		IG_like	294..390	CDD:214653	18/95 (19%)
		Ig	296..387	CDD:143165	16/90 (18%)
Slitrk3	NP_001101153.1	leucine-rich repeat	81..102	CDD:275380
		leucine-rich repeat	103..126	CDD:275380
		LRR_8	105..161	CDD:290566
		leucine-rich repeat	127..150	CDD:275380
		LRR_8	150..208	CDD:290566
		leucine-rich repeat	151..174	CDD:275380
		leucine-rich repeat	175..197	CDD:275380
		leucine-rich repeat	198..402	CDD:275380	4/22 (18%)
		LRRCT	232..>270	CDD:214507
		leucine-rich repeat	403..433	CDD:275380	5/53 (9%)
		LRR_8	432..492	CDD:290566	20/59 (34%)
		LRR_4	433..473	CDD:289563	13/39 (33%)
		leucine-rich repeat	434..457	CDD:275380	7/22 (32%)
		LRR_4	456..497	CDD:289563	14/40 (35%)
		leucine-rich repeat	458..481	CDD:275380	10/22 (45%)
		leucine-rich repeat	482..501	CDD:275380	5/18 (28%)
		leucine-rich repeat	506..528	CDD:275380	7/21 (33%)
		leucine-rich repeat	529..553	CDD:275380	1/23 (4%)
		LRRCT	562..>597	CDD:214507	18/80 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000